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Shared Pathways to Peptides in Biochemistry and Prebiotic Chemistry through Ester Amide Exchange Chemistry Cover

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Shared Pathways to Peptides in Biochemistry and Prebiotic Chemistry through Ester Amide Exchange Chemistry

Volume 6 (2026): Issue 1 (January 2026)

By: Yishi Ezerzer, Disha-Gajanan Hiregange, Anat Bashan, Ada Yonath and Moran Frenkel-Pinter

Open Access

|Apr 2026

Figures & tables

Figures & Tables

Conceptual link between prebiotic chemistry and modern biology. Ester–amide exchange reactions occurring in a small aqueous pond enable peptide formation, paralleled by an analogous ester–amide exchange reaction in the ribosome that elongates the peptide chain during protein synthesis – all connected by the chemical evolution of a protoribosome complex.

Articles in this issue

DOI: https://doi.org/10.2478/biocosmos-2026-0002 | Journal eISSN: 2719-8634

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Language: English

Page range: 19 - 24

Published on: Apr 30, 2026

Published by: The Israel Biocomplexity Center

In partnership with: Paradigm Publishing Services

Keywords:

origins of life,

chemical evolution,

wet-dry cycling,

peptide evolution,

Related subjects:

Evolutionary biology,

Astronomy and astrophysics,

History of philosophy,

History of philosophy, other

© 2026 Yishi Ezerzer, Disha-Gajanan Hiregange, Anat Bashan, Ada Yonath, Moran Frenkel-Pinter, published by The Israel Biocomplexity Center
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 6 (2026): Issue 1 (January 2026)

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