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Characteristics and Pleiotropic Effects of Ashwagandha – A Literature Review Cover

Characteristics and Pleiotropic Effects of Ashwagandha – A Literature Review

Open Access
|Dec 2024

Abstract

Ashwagandha, also known as Winter Cherry (Withania somnifera), is one of the most important plants used in traditional Indian medicine. In our study, we focused on presenting the comprehensive effects of ashwagandha, which exhibits numerous health benefits, including anti-stress, hypoglycemic, cardioprotective, anti-inflammatory, neuroprotective, and anti-cancer properties. It has been shown that ashwagandha supports stress reduction, enhances physical endurance, lowers glucose levels and improves blood lipid profiles, which can be beneficial in the treatment of diabetes. Extracts from this plant contribute to heart health by reducing oxidative stress markers and supporting heart tissue regeneration. Additionally, numerous studies indicate its anti-cancer properties due to the presence of withaferin A, which activates apoptosis processes in cancer cells.

The paper also discusses the effects of ashwagandha on hormones and fertility, highlighting improvements in semen quality in men. Although ashwagandha is generally well-tolerated, the literature presents some side effects, including incidental cases of hepatotoxicity and thyrotoxicosis, which necessitate caution in its use. In conclusion, ashwagandha has a broad therapeutic potential; however, further clinical studies are essential to better understand its mechanisms of action and to establish safe dosing guidelines.

DOI: https://doi.org/10.2478/bgbl-2024-0031 | Journal eISSN: 2956-6851 | Journal ISSN: 0373-174X
Language: English
Page range: 181 - 198
Published on: Dec 16, 2024
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2024 Urszula Miłkowska, Piotr Franciszek Kurzyna, Klaudia Kołakowska, Igor Lis, Gabriela Maria Piech, published by The Medical Library named after S. Konopka in Warsaw
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.