The effect of cranberry juice on bone growth and development using an animal model

Charuta, Anna; Paziewska, Agnieszka; Dyńka, Damian; Krzęcio-Nieczyporuk, Elżbieta; Rymuza, Katarzyna; Kosowska, Michalina; Jóźwik, Artur; Marchewka, Joanna; Dzierzęcka, Małgorzata; Ławiński, Michał; Horbańczuk, Jarosław Olav

doi:10.2478/aspr-2023-0025

Abstract

The aim of the study was to analyze the effect of cranberry juice on bone microstructure. The research was carried out on an animal model (experimental animals, Windstar rats). The structure of the proximal tibial metaphysis was analyzed using micro CT, and X-ray microtomography equipment with a VDS 1.3Mp FW camera. It was found that cranberry juice increased bone mineral density (BMD). It also increased the thickness of the bone trabeculae (Tb.Th). The highest BMD value was observed in group drinking a 10% concentration of cranberry juice. In rats drinking 25% concentration, an increase in Tb.Th was observed compared to the two other groups, including the control group.

References

1. ADAMCZAK A., BUCHWALD W., KOZLOWSKI J., 2011 - Variation in the content of flavonols and main organic acids in the fruit of European cranberry (Oxycoccus palustris Pers.) growing in peatlands in peatlands of North-Western Poland. Herba Po-lonica 54.
Search in Google Scholar
2. AGHAJANIAN P., HALL S., WONGWORAWAT M.D., MOHAN S., 2015 - The roles and mechanisms of actions of vitamin c in bone: new developments. Journal Bone Mineral Research 30, 1945-55.
Search in Google Scholar
3. BARANOWSKA M., BARTOSZEK A., 2016- Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry. Postępy Higieny i Medycyny Doświadczalnej (Online).31, 1460-1468.
Search in Google Scholar
4. CHOPRA A.S., LORDAN R., HORBAŃCZUK O.K., ATANASOV,A.G., CHOPRA I., HORBAŃCZUK J.O., JÓŹWIK A., ARKELLS N., 2022-The current use and evolving landscape of nutraceuticals. Pharmacological Research 175.
Search in Google Scholar
5. CLYNES M.A., HARVEY N.C., CURTIS E.M., FUGGLE N.R., DENNISON E.M., COOPER C., 2020-The epidemiology of osteoporosis. British Medical Bulletin133, 105-117.
Search in Google Scholar
6. COOPER R.G., NARANOWICZ H., MALISZEWSKA E., TENNETT A., HORBANCZUK J.O., 2008 - Sex-based comparison of limb segmentation in ostriches aged 14 months with and without tibiotarsal rotation. Journal of the South African Veterinary Assosiation 79, 142-144.
Search in Google Scholar
7. DEPHILLIPO N.N., AMAN Z.S., KENNEDY M.I., BEGLEY J.P., MOATSHE G., LAPRADE R.F., 2018- Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: a systematic review. Orthopaedic Journal of Sports Medicine 25. 6, 2325967118804544.
Search in Google Scholar
8. FEGHALI K., FELDMAN M., LA V.D., SANTOS J., GRENIER D., 2012-Cranberry proanthocyanidins: natural weapons against periodontal diseases. Journal of Agricultural and Food Chemistry 60, 5728-35.
Search in Google Scholar
9. GU R., LIU H., HU M., ZHU Y., LIU X., WANG F., WU L., SONG D., LIU Y. D., 2023 - Mannose prevents bone loss under weightlessness. Journal of Translational Medicine 9, 21, 8.
Search in Google Scholar
10. HARRIS E., 2023 - Updated Meta-analysis: Cranberry Products Reduced UTI Risk. JAMA. 329, 1730.
Search in Google Scholar
11. HUA YANG, NANNAN HAN, ZHENHUA LUO, JUNJI XU, LIJIA GUO, YI LIU., 2023-D-mannose alleviated alveolar bone loss in mice with experimental periodontitis via regulating the anti-inflammatory effect of amino acids. Journal of Periodontology 94, 542-553.
Search in Google Scholar
12. HUMINIECKI L., HORBAŃCZUK J., 2018 - The functional genomic studies of resveratrol in respect to its anti-cancer effects. Biotechnology Advances 36, 1699-1708.
Search in Google Scholar
13. HUMINIECKI L., HORBANCZUK J., ATANASOV A.G., 2017 - The functional genomic studies of curcumin. Seminar Cancer in Biology 46, 107-118.
Search in Google Scholar
14. JURIKOVA T., SKROVANKOVA S., MLCEK J., BALLA S., SNOPEK L., 2019- Compounds, Antioxidant Activity, and Biological Effects of European Cranberry (Vaccinium oxycoccos). Molecules 24, 24.
Search in Google Scholar
15. LI CH., LI J., JIANG F., LI Y., TZVETKOV N.T., HORBANCZUK J.O., ATANASOV A.G., WANG D., 2021 - Vasculoprotective effects of ginger (Zingiber officinale Roscoe) and underlying molecular mechanisms. Food and Function 12, 1897-1913.
Search in Google Scholar
16. LIN X., YUAN G., LI Z., ZHOU M., HU X., SONG F., SHAO S., FU F., ZHAO J., XU J., LIU Q., FENG H., 2020- Ellagic acid protects ovariecto-my-induced bone loss in mice by inhibiting osteoclast differentiation and bone resorption. Journal of Cellular Physiology 235, 5951-5961.
Search in Google Scholar
17. LIN Z,. MIAO J., ZHANG T., HE M., ZHOU X., ZHANG H., GAO Y., BAI L., 2021- d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway. Biomed Pharma-cother 135, 111199.
Search in Google Scholar
18. LIU H., GU R., ZHU Y., LIAN X., WANG S., LIU X., PING Z., LIU Y., ZHOU Y., 2020- D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects. Therapeutic Advances in Chronic Disease 11:2040622320912661.
Search in Google Scholar
19. MALEKIAN S., MIRGHAFOURVAND M., NAJAFIPOUR F., OSTADRAHIMI A., GHASSABABDOLLAHI N., FARSHBAF-KHALILI A., 2023- The Associations between bone mineral density and oxidative stress biomarkers in postmenopausal women. Korean Journal of Family Medicine 44, 95-101.
Search in Google Scholar
20. MARCUCCI G., DOMAZETOVIC V., NEDIANI C., RUZZOLINI J., FAVRE C., BRANDI M.L., 2023- Oxidative stress and natural antioxidants in osteoporosis: novel preventive and therapeutic approaches. Antioxidants 12, 373.
Search in Google Scholar
21. MEENA J., THOMAS C.C., KUMAR J., RAUT S., HARI P., 2021-Non-antibiotic interventions for the prevention of urinary tract infections in children: a systematic review and meta-analysis of randomized controlled trials. European Journal of Pediatrics 180, 3535-3545.
Search in Google Scholar
22. MOZOS I., FLANGEA C., VLAD D.C., GUG C., MOZOS C., STOIAN D., LUCA C.T., HORBAŃCZUK J.O., HORBAŃCZUK O.K., ATANASOV A.G., 2021-Effects of anthocyanins on vascular health. Biomolecules 11, 811.
Search in Google Scholar
23. NEMZER B.V., AL-TAHER F., YASHIN A., REVELSKY I., YASHIN Y., 2022- Cranberry: Chemical Composition, Antioxidant Activity and Impact on Human Health: Overview. Molecules 23, 27, 1503.
Search in Google Scholar
24. NOUR J., MOREGOLA A., SVECLA M., DA DALT L., BELLINI R., NEYROLLES O., FADINI G.P., ROMBOUTS Y., ALBIERO M., BONACINA F., NORATA G.D., 2022- Mannose receptor deficiency impacts bone marrow and circulating immune cells during high fat diet induced obesity. Metabolites 1, 12, 1205.
Search in Google Scholar
25. ORNSTRUP M.J., HARSLØF T., KJÆR T.N., LANGDAHL B.L., PEDERSEN S.B., 2014-Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. The Journal of Clinical Endocrinology and Metabolism 99, 4720-9.
Search in Google Scholar
26. PAPPAS E., SCHAICH KM., 2009- Phytochemicals of cranberries and cranberry products: characterization, potential health effects, and processing stability. Critical Reviews in Food Science and Nutrition 49, 741-81.
Search in Google Scholar
27. PIECZYNSKA M.D., YANG Y., PETRYKOWSKI S., HORBANCZUK O.K., ATANASOV A.G., HORBAŃCZUK J.O., 2020 - Gut microbiota and its metabolites in atherosclerosis development. Molecules 25(3), 594.
Search in Google Scholar
28. TEWARI D., MOCAN A., PARVANOV E.D., SAH A,N., NABAVI S.N. HUMINIECKI L, M,A, Z.,F., LEE Y.,Y., HORBAŃCZUK J.O, ATANASOV A.,G., 2017- Ethnopharmacological approaches for therapy of jaundice: Part II. Highly used plant species from acanthaceae, euphorbiaceae, asteraceae, combretaceae, and fabaceae families. Frontiers in Pharmacology 15, 8, 518.
Search in Google Scholar
29. TOU JC., 2015- Evaluating resveratrol as a therapeutic bone agent: preclinical evidence from rat models of osteoporosis. Annals of the New York Academy of Sciences Journal 1348, 75-85.
Search in Google Scholar
30. VIGUET-CARRIN S., GARNERO P., DELMAS P.D., 2006 - The role of collagen in bone strength. Osteoporosis International 17, 319-36.
Search in Google Scholar
31. VILLARREAL A., STOECKER B.J., GARCIA C., GARCIA K., RIOS R., GONZALES C., MANDADI K., FARAJI B., PATIL B.S., DEYHIM F., 2007- Cranberry juice improved antioxidant status without affecting bone quality in orchidectomized male rats. Phytomedicine. 14: 815-20.
Search in Google Scholar
32. VIVIAN ALONSO-GARCIA, CUTTER CHABOYA, QIONGYU LI, BRYAN LE, TIMOTHY J CONGLETON, JOSE FLOREZ, VICTORIA TRAN, GANG-YU LIU, WEI YAO, CARLITO B LEBRILLA, FERNANDO A FIERRO., 2020- High Mannose N-Glycans Promote Migration of Bone-Marrow-Derived Mes-enchymal Stromal Cells. International Journal of Molecular Sciences 21, 7194.
Search in Google Scholar
33. WANG D., ÖZEN C., ABU-REIDAH I.M., CHGURUPATI S., PATRA J.K., HORBAŃCZUK J.O., JÓŹWIK A., TZVETKOV N.T., UHRIN P., ATANASOV A.G., 2018 - Vasculoprotective Effects Of Pomegranate (Punica Granatum L.). Frontiers In Pharmacology 9, 544.
Search in Google Scholar
34. WANG D., ZHANG L., HUANG J., HIMABINDU K., TEWARI D., HORBAŃCZUK J.O, XU S., CHEN Z., ATANASOV A.G., 2020 - Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine, Trends in Food Science & Technology https://doi. org/10.1016/j.tifs.2020.11.024.
Search in Google Scholar
35. XIA J.Y., YANG C., XU D.F., XIA H., YANG L.G., SUN G.J., 2021- Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis. PLoS One 2. 16.9.
Search in Google Scholar
36. XU H., CHEN F., LIU T., XU J., LI J., JIANG L., WANG X., SHENG J., 2020-Ellagic acid blocks RANKL-RANK interaction and suppresses RANKL-induced osteoclastogenesis by inhibiting RANK signalling pathways. Chemico-Biological Interactions Journal 331:109235.
Search in Google Scholar
37. YEUNG A.W.K., AGGARWAL B., BARRECA D., BATTINO M., BELWAL T., HORBAŃCZUK O., BERINDAN-NEAGOE I., BISHAYEE A., DAGLIA M., DEVKOTA H., ECHEVERRÍA J., EL-DEMERDASH A., ORHAN I., GODFREY K., GUPTA V., HORBAŃCZUK J., MODLIŃSKI J., HUBER L., HUMINIECKI L., JÓŹWIK A., MARCHEWKA J., MILLER M., MOCAN A., MOZOS I., NABAVI S., NABAVI S., PIECZYNSKA M., PITTALÀ V., RENGASAMY K., SILVA A., SHERIDAN H., STANKIEWICZ A., STRZAŁKOWSKA N., SUREDA A., TEWARI D., WEISSIG V., ZENGIN G., ATANASOV A., 2018 - Dietary natural products and their potential to influence health and disease including animal model studies. Animal Science Papers and Reports. 36, 345-358.
Search in Google Scholar
38. YEUNG A.W.K., AGGARWAL B.B., ORHAN I.E., HORBAŃCZUK O.K., BARRECA D., BATTINO M., BELWAL T., BISHAYEE A., DAGLIA M., DEVKOTA H. P., ECHEVERRÍA J., ELDEMERDASH A., BALACHEVA A., GEORGIEVA M., GODFREY K., GUPTA V., HORBAŃCZUK J. O., HUMINIECKI L., JÓŹWIK A., STRZAŁKOWSKA N., MOCAN A., MOZOS, I., NABAVI S. M., PAJPANOVA T., PITTALA V., FEDER-KUBIS J., SAMPINO S., SILVA A. S., SHERIDAN H., SUREDA A., TEWARI D., WANG D., WEISSIG V., YANG Y., ZENGIN G., SHANKER K., MOOSAVI M. A., SHAH M. A., KOZUHAROVA E., ALRIMAWI F., DURAZZO A., LUCARINI M., SOUTO E. B., SANTINI A., MALAINER C., DJILIANOV D., TANCHEVA L.P., LI H.B., GAN R.Y., TZVETKOV N.T., ATANASOV A. G. 2019 - Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis - a review. Animal Science Papers and Reports 37, 103-118.
Search in Google Scholar
39. YEUNG A.W.K., CHOUDHARY N., TEWARI D., EL-DEMERDASH A., HORBAŃCZUK O.K., DAS N., PIRGOZLIEV V., LUCARINI M., DURAZZO A., SOUTO E.B., SANTINI A., DEVKOTA H.P., UDDIN M. S., ECHEVERRIA J., WANG D., GAN R. Y., BRNCIC M., KALFIN R. E., TZVETKOV N. T., JOZWIK A., SOLKA,M., STRZALKOWSKA N., HORBANCZUK J.O., ATANASOV A.G., 2021a - Quercetin: total-scale literature landscape analysis of a valuable nutraceutical with numerous potential applications in the promotion of human and animal health - a review. Animal Science Papers and Reports 39, 199-212.
Search in Google Scholar
40. YEUNG A.W.K., CHOUDHARY N., TEWARI D., EL-DEMERDASH A., TOMCZYK M., DAS N., PIRGOZLIEV V., LUCARINI M., DURAZZO A., SOUTO E.B., SANTINI A., DEVKOTA H.P., UDDIN M.S., ECHEVERRÍA J., WANG D., GAN R-Y., BRNČIĆ M., KALFIN R.E., De R., CENANOVIC M., SAI C.S., KAPOOR B., KIRILOV K., TZVETKOV N.T., BELAKOVA B., UHRIN P., JÓŹWIK A., HORBANCZUK O.K., STRZAŁKOWSKA N., KOSZARSKA M., CHARUTA A., HORBAŃCZUK J.O., ATANASOV A.G., 2022 – Lycopene: total-scale literature landscape analysis of a valuable nutraceutical with numerous potential applications in the promotion of human and animal health. Animal Science Papers and Reports 40 (2), 119-134.
Search in Google Scholar
41. YEUNG A.W.K, KSEPKA N., MATIN M.,WANG D., SOUTO E.,STOYANOV J., ECHEVERRÍA J., TEWARI D., HORBANCZUK J., LUCARINI M., DURAZZO A., MARCHEWKA J., PIRGOZLIEV V., GAN R.,TZVETKOV N., WYSOCKI K., MATIN F., LITVINOVA O., BISHAYEE A., DEVKOTA H., EL-DEMERDASH A., BRNČIĆ M., SANTINI A., HORBAŃCZUK O., MICKAEL M., ŁAWINSKI M., DAS N., SIDDIQUEA B., HRG D., ATANASOV A.G., 2023 – Dietary factors in nonalcoholic fatty liver disease: impacts on human and animal health - a review. Animal Science Papers and Reports 41, 3, 179-194.
Search in Google Scholar
42. YEUNG A.W.K., ORHAN I.E., AGGARWAL B.B., BATTINO M., BELWAL T., BISHAYEE A., DAGLIA M., DEVKOTA H.P., EL-DEMERDASH A., BALACHEVA A.A., GEORGIEVA M.G., GUPTA V.K., HORBAŃCZUK J.O., JOZWIK A., MOZOS I., NABAVI,S. M., PITTALÀ V., FEDER-KUBIS J., SANCHES SILVA A., SHERIDAN H., SUREDA A., WANG D., WEISSIG V., YANG Y., ZENGIN G., SHANKER K., MOOSAVI M.A., SHAH M.A., AL-RIMAWI F., DURAZZO A., LUCARINI M., SOUTO E. B., SANTINI A., DJILIANOV D., DAS N., SKOTTI E., WIECZOREK A., LYSEK-GLADYSINSKA M. W., MICHALCZUK M., HORBAŃCZUK O.K., TZVETKOV N. T., ATANASOV A.G., 2020a - Berberine, a popular dietary supplement for human and animal health: Quantitative research literature analysis-a review. Animal Science Papers and Reports 38, 5-19.
Search in Google Scholar
43. YEUNG A W. K., TZVETKOV N. T., EL-DEMERDASH A., HORBANCZUK O. K., DAS N., PIRGOZLIEV V., LUCARINI M., DURAZZO A., SOUTO E. B., SANTINI A., DEVKOTA H. P., UDDIN M., ECHEVERRÍA J., WANG D., GAN R. Y., BRNČIĆ M., KALFIN R., TANCHEVA L. P., TEWARI D., BERINDAN-NEAGOE I., SAMPINO S., STRZAŁKOWSKA N., MARCHEWKA J., JOZWIK A., HORBANCZUK J. O., ATANASOV A. G. 2021b - Apple polyphenols in human and animal health. Animal Science Papers and Reports 39, 105-118.
Search in Google Scholar
44. 17. YEUNG A.W.K., TZVETKOV N..T, BALACHEVA A.A., GEORGIEVA M.G., GAN R.Y., JOZWIK A., PYZEL B., HORBAŃCZUK J.O., NOVELLINO E., DURAZZO A., LUCARINI M., CAMILLI E., SOUTO E.B., ATANASOV A.G., SANTINI A., 2020b - Lignans: quantitative analysis of the research literature. Frontiers in Pharmacology 11, 37. doi: 10.3389/fphar.2020.00037. PMID: 32116713; PMCID: PMC7020883.
Search in Google Scholar
45. YEUNG A.W.K., TZVETKOV N.T., DURAZZO A., LUCARINI M., SOUTO E.B., SANTINI A., GAN R.-Y., JOZWIK A., GRZYBEK W., HORBAŃCZUK J.O., MOCAN A., ECHEVERRÍA J., WANG D., ATANASOV A.G., 2020c - Natural products in diabetes research: quantitative literature analysis. Natural Product Research doi: 10.1080/14786419.2020.1821019.
Search in Google Scholar
46. ZAFFAR A., VIKAS PANDEY, NAVITA GUPTA, LEENA SAPRA, HAMID Y. DAR, NITI SHOKEEN, ASHA BHARDWAJ, AYAAN AHMAD, VANDANA SONI, RUPESH K. SRIVASTAVA., 2020 - Phytoconstituents as novel osteo-protective agents: Implications in bone health. Frontiers in. Bioscience (Landmark Ed). 25:1259-1296.
Search in Google Scholar

The effect of cranberry juice on bone growth and development using an animal model

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