The role of long non-coding RNAs in intramuscular fat deposition in livestock: Current research

Maj, Dorota; Gonkiewicz, Wiktoria

doi:10.2478/aoas-2025-0070

Abstract

Meat products are vital components of the human diet, and intramuscular fat (IMF) is a key indicator of meat quality. Long non-coding RNAs (lncRNAs) play essential roles in diverse biological processes. Here, we review current research on the role of lncRNAs in the process of IMF deposition and its impact on meat quality in livestock such as cattle, pigs, sheep, and poultry. The study also presents the characteristics of lncRNAs and their function. LncRNAs serve as regulators in gene expression networks associated with fat deposition. In addition, lncRNAs can promote or inhibit the differentiation of preadipocytes into adipocytes. Studies indicate a potential role for individual lncRNAs in the development of IMF in animals through involvement in signaling pathways related to fat deposition and lipid metabolism. Understanding the regulatory network and the role of lncRNAs in the accumulation of IMF could help improve meat quality, which is of great value to consumers.

References

Bakhtiarizadeh M.R., Salami S.A. (2019). Identification and Expression Analysis of Long Noncoding RNAs in Fat-Tail of Sheep Breeds. G3: Genes|Genomes|Genetics, 9: 1263–1276.
Search in Google Scholar Back to article
Bao G., Li, S., Zhao F., Wang J., Liu X., Hu J., Shi B., Wen Y., Zhao L. Luo Y. (2022). Comprehensive Transcriptome Analysis Reveals the Role of lncRNA in Fatty Acid Metabolism in the Longissimus Thoracis Muscle of Tibetan Sheep at Different Ages. Front. Nutr., 9: 847077.
Search in Google Scholar Back to article
Bridges M. C., Daulagala A. C., Kourtidis A. (2021). LNCcation: lncRNA localization and function. J. Cell Biol., 220(2): e202009045.
Search in Google Scholar Back to article
Cai H., Li M., Jian W., Song C., Huang Y., Lan X., et al. (2020). A novel lncRNA BADLNCR1 inhibits bovine adipogenesis by repressing GLRX5 expression. J. Cell. Mol. Med., 24(13): 7175–86.
Search in Google Scholar Back to article
Cai B., Ma M., Zhang J., Kong S., Zhou Z., Li, Z., Abdalla B.A., Xu H., Zhang X., Lawal R.A., Nie Q. (2022). Long noncoding RNA ZFP36L2-AS functions as a metabolic modulator to regulate muscle development. Cell Death Dis., 13(4): 389.
Search in Google Scholar Back to article
Cantile M., Cerrone M., Bonito M., Moccia P, Tracey M., Ferrara G., Budillon A. (2024). Endocrine nuclear receptors and long non-coding RNAs reciprocal regulation in cancer (Review). Int. J. Oncol., 64: 7.
Search in Google Scholar Back to article
Chen L., Zhang T., Zhang S., Huang J., Zhang G., Xie K., Wang J., Wu H., Dai G. (2019). Identification of Long Non-Coding RNA Associated Competing Endogenous RNA Network in the Differentiation of Chicken Preadipocytes. Genes. 10:795.
Search in Google Scholar Back to article
Chen Y., Zhao S., Ding R., Li H., Yang C.X., Du Z.Q. (2022). Identification of a Long Noncoding RNA (lncPRDM16) Inhibiting Preadipocyte Proliferation in the Chicken. J. Agric. Food Chem., 70: 1335–1345.
Search in Google Scholar Back to article
Chen R., Liao K., Liao H., Zhang L., Zhao H., Sun J. (2023). Screening and functional validation of lipid metabolism-related lncRNA-46546 based on the transcriptome analysis of early embryonic muscle tissue in chicken. Animal Bioscience. 36(2): 175-190.
Search in Google Scholar Back to article
Choi Y. M., Garcia L. G., Lee K. (2019). Correlations of Sensory Quality Characteristics with Intramuscular Fat Content and Bundle Characteristics in Bovine Longissimus Thoracis Muscle. Food Sci. Anim. Resour., 39(2): 197–208.
Search in Google Scholar Back to article
Cui H., Liu L., Liu X., Wang Y., Luo N., Tan X., Zhu Y., Liu R., Zhao G., Wen J. (2022). A selected population study reveals the biochemical mechanism of intramuscular fat deposition in chicken meat. J. Anim. Sci. Biotechnol., 13: 54.
Search in Google Scholar Back to article
Ding Y., Hou Y., Ling Z., Chen Q., Xu T., Liu L., Yu N., Ni W., Ding X., Zhang X., Zheng X., Bao W., Yin Z. (2022). Identification of Candidate Genes and Regulatory Competitive Endogenous RNA (ceRNA) Networks Underlying Intramuscular Fat Content in Yorkshire Pigs with Extreme Fat Deposition Phenotypes. Int. J. Mol. Sci., 23(20): 12596.
Search in Google Scholar Back to article
Dou J., Thangaraj S.V., Puttabyatappa M., Elangovan V.R., Bakulski K., Padmanabhan V. (2023). Developmental programming: Adipose depot-specific regulation of non-coding RNAs and their relation to coding RNA expression in prenatal testosterone and prenatal bisphenol-A -treated female sheep. Mol. Cell Endocrinol., 564: 111868.
Search in Google Scholar Back to article
Dou Y., Qi K., Liu Y., Li C., Song C., Wei Y., Zhang Z., Li X., Wang K., Li X., Qiao R., Yang F., Han X. (2023). Identification and Functional Prediction of Long Non-Coding RNA in Longissimus Dorsi Muscle of Queshan Black and Large White Pigs. Genes, 14(1): 197.
Search in Google Scholar Back to article
Feng H., Liu T., Yousuf S., Zhang X., Huang W., Li A., Xie L., Miao X. (2023). Identification and analysis of lncRNA, miRNA and mRNA related to subcutaneous and intramuscular fat in Laiwu pigs. Front. Endocrinol., 13: 108146013.
Search in Google Scholar Back to article
Frank D., Joo S.-T., Warner R. (2016). Consumer Acceptability of Intramuscular Fat. Korean J. Food Sci. Anim. Resour., 36(6): 699–708.
Search in Google Scholar Back to article
Gong Y., Lin Z., Wang Y., Liu,Y. (2023). Research progress of non-coding RNAs regulation on intramuscular adipocytes in domestic animals. Gene, 860: 147226.
Search in Google Scholar Back to article
Gudenas B. L., Wang L. (2018). Prediction of LncRNA Subcellular Localization with Deep Learning from Sequence Features. Sci. Rep. 8: 16385.
Search in Google Scholar Back to article
Han F., Li J., Zhao R., Liu L., Li L., Li Q., He J., Liu N. (2021). Identification and co-expression analysis of long noncoding RNAs and mRNAs involved in the deposition of intramuscular fat in Aohan fine-wool sheep. BMC Genomics. 22: 98.
Search in Google Scholar Back to article
Hao, Z., Jin, X., Hickford, J.G.H., Zhou H., Wang L., Wang J. et al. (2024). Screening and identification of lncRNAs in preadipocyte differentiation in sheep. Sci. Rep., 14: 5260.
Search in Google Scholar Back to article
Hou X., Wang L., Zhao F., Liu X., Gao H., Shi L., Yan H., Wang L., Zhang L. (2021). Genome-Wide Expression Profiling of mRNAs, lncRNAs and circRNAs in Skeletal Muscle of Two Different Pig Breeds. Animals, 11: 3169.
Search in Google Scholar Back to article
Hu G., Do D. N., Davoudi P., Miar Y. (2022). Emerging Roles of Non-Coding RNAs in the Feed Efficiency of Livestock Species. Genes, 13(2): 297.
Search in Google Scholar Back to article
Huang W., Zhang X., Li A., Xie L., Miao,X. (2018). Genome-Wide Analysis of mRNAs and lncRNAs of Intramuscular Fat Related to Lipid Metabolism in Two Pig Breeds. Cell. Physiol. Biochem., 50(6): 2406–2422.
Search in Google Scholar Back to article
Jiang, R., Li, H., Huang, Y., Lan, X., Lei, C., Chen, H. (2020). Transcriptome profiling of lncRNA related to fat tissues of Qinchuan cattle. Gene, 742: 144587.
Search in Google Scholar Back to article
Jiang Y., Liu J., Liu H., Zhang W., Li X., Liu L., Zhou M., Wang J., Su S., Ding X., Wang C. (2022). miR-381-3p Inhibits Intramuscular Fat Deposition through Targeting FABP3 by ceRNA Regulatory Network. Biology. 11: 1497.
Search in Google Scholar Back to article
Jin Y., Cheng B., Wang H., Bai X., Zhang Q., Wang N., Li H., Wang S. (2022). The landscape of the long non-coding RNAs and circular RNAs of the abdominal fat tissues in the chicken lines divergently selected for fatness. BMC Genomics, 23:790.
Search in Google Scholar Back to article
Jin Z., Gao H., Fu Y., Ren R., Deng X., Chen Y., Hou X.,Wang Q., Song G., Fan N., et al. (2024). Whole-Transcriptome Analysis Sheds Light on the Biological Contexts of Intramuscular Fat Deposition in Ningxiang Pigs. Genes, 15: 642.
Search in Google Scholar Back to article
Kopp F., Mendell J. T. (2018). Functional Classification and Experimental Dissection of Long Noncoding RNAs. Cell, 172(3): 393-407.
Search in Google Scholar Back to article
Li M., Sun X., Cai H., Sun Y., Plath M., Li C., Lan X., Lei C., Lin F., Bai Y., Chen H. (2016) Long non-coding RNA ADNCR suppresses adipogenic differentiation by targeting miR-204. Biochim. Biophys. Acta, Biomembr., 1859: 871–882.
Search in Google Scholar Back to article
Li A., Hu Y., Liu X., Zhao L., Tian Q., Du M. (2018). PSXV-9 a novel anti-sense lncRNA of CEBPA inhibits bovine adipogenic differentiation. J. Anim. Sci., 96(Suppl 3): 245
Search in Google Scholar Back to article
Li M., Gao Q., Tian Z., Lu X., Sun Y., Chen Z., Zhang H., Mao Y., Yang Z. (2019). MIR221HG is a novel long noncoding RNA that inhibits bovine adipocyte differentiation. Genes, 11: 29–47
Search in Google Scholar Back to article
Li D., Li F., Jiang K., Zhang M., Han R., Jiang R., Li Z., Tian Y., Yan F., Kang X., Sun G. (2019). Integrative analysis of long noncoding RNA and mRNA reveals candidate lncRNAs responsible for meat quality at different physiological stages in Gushi chicken. PLoS One, 14(4): e0215006.
Search in Google Scholar Back to article
Li R., Li, B., Jiang A., Cao Y., Hou L., Zhang Z., Zhang X., Liu H., Kim K.H., Wu W. (2020). Exploring the lncRNAs Related to Skeletal Muscle Fiber Types and Meat Quality Traits in Pigs. Genes, 11: 883.
Search in Google Scholar Back to article
Li M., Zhu M., Chai W., Wang Y., Song Y., Liu B., Cai C., Song Y., Sun X., Xue P., Wang C. (2021). Determination of the Heterogeneity of Intramuscular Fat and Visceral Adipose Tissue From Dezhou Donkey by Lipidomies and Transcriptomics Profiling. Front. Nut., 8: 746684.
Search in Google Scholar Back to article
Li, J., Zhao X., Wang Y., Wang J. (2022). Comprehensive Analysis of Differentially Expressed mRNAs, lncRNAs and circRNAs Related to Intramuscular Fat Deposition in Laiwu Pigs. Genes, 13(8): 1349.
Search in Google Scholar Back to article
Li R., Zhu R., Yang X., Feng Y., He Q., Wang H., Liu Q., Shi, D., Huang J. (2024). The role of lncFABP4 in modulating adipogenic differentiation in buffalo intramuscular preadipocytes. Anim. Sci. J., 95: e13951.
Search in Google Scholar Back to article
Liu X., Wei S., Deng S., Li D., Liu K., Shan B., Shao Y., Wei W., Chen J., Zhang L. (2019). Genome-wide identification and comparison of mRNAs, lncRNAs and circRNAs in porcine intramuscular, subcutaneous, retroperitoneal and mesenteric adipose tissues. Anim. Genet., 50: 228–241.
Search in Google Scholar Back to article
Liu Y., Xing K., Ao H., Zhang F., Zhao X., Liu H., Shi Y., Yu Y., Wang C. (2023). Competing endogenous RNA network construction based on long non-coding RNAs, microRNAs, and mRNAs related to fat deposition in Songliao black swine. Anim. Genet., 54: 132–143.
Search in Google Scholar Back to article
Ma L., Zhang M., Jin Y., Erdenee S., Hu L., Chen H., Cai Y., Lan X. (2018). Comparative Transcriptome Profiling of mRNA and lncRNA Related to Tail Adipose Tissues of Sheep. Front. Genet., 9: 365.
Search in Google Scholar Back to article
Ma X., Yang X., Zhang D., Zhang W., Wang X., Xie K., He J., Mei C., Zan L. (2023). RNA-seq analysis reveals the critical role of the novel lncRNA BIANCR in intramuscular adipogenesis through the ERK1/2 signaling pathway. J. Anim. Sci. Biotechnol. 14: 21.
Search in Google Scholar Back to article
Ma X., He Y., Liu C., Zhu T., Li D., Li W., Sun G., Kang X. (2024). Long Noncoding RNA 6302 Regulates Chicken Preadipocyte Differentiation by Targeting SLC22A16. Genes (Basel),15(6): 758.
Search in Google Scholar Back to article
Miao Z., Wang S., Zhang J., Wei P., Guo L., Liu D., Wang Y., Si M. (2018) Identification and comparison of long non-conding RNA in Jinhua and Landrace pigs. Biochem. Biophys. Res. Commun., 506: 765-771.
Search in Google Scholar Back to article
Muniz M.M.M., Fonseca L.F.S., Scalez D C.B., Vega A.S., Silva D B., Ferro J.A., Chardulo A.L., Baldi F., Cánovas A., de Albuquerque L.G. (2022). Characterization of novel lncRNA muscle expression profiles associated with meat quality in beef cattle. Evol. Appl. 15: 706–718.
Search in Google Scholar Back to article
Poklukar K., Čandek-Potokar M., Batorek Lukač N., Tomažin U., Škrlep M. (2020). Lipid Deposition and Metabolism in Local and Modern Pig Breeds: A Review. Animals, 10: 424.
Search in Google Scholar Back to article
San J., Du Y., Wu G., Xu R., Yang J., Hu J. (2021). Transcriptome analysis identifies signaling pathways related to meat quality in broiler chickens – the extracellular matrix (ECM) receptor interaction signaling pathway. Poult, Sci., 100: 101135.
Search in Google Scholar Back to article
Sandmann C.L., Schulz J.F., Ruiz-Orera J., Kirchner M., Ziehm M., Adami E., et al. (2023). Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames. Mol. Cell., 83(6): 994-1011 e18.
Search in Google Scholar Back to article
Shi M., Huang L, Meng S, Wang H., Zhang J., Miao Z., Li Z. (2024). Identification of several lncRNA-mRNA pairs associated with marbling trait between Nanyang and Angus cattle. BMC Genomics, 25: 696.
Search in Google Scholar Back to article
Singh D.R., Dalton M.P., Cho E.E., Pribadi M.P., Zak T.J., Seflova J., Makarewich C.A., Olson E.N., Robia S.L. (2019). Newly discovered micropeptide regulators of SERCA form oligomers but bind to the pump as monomers. J. Mol. Biol., 431: 4429–4443.
Search in Google Scholar Back to article
Suarez-Vega A., Arranz J.J., Perez V., de la Fuente L.F., Mateo J., Gutierrez-Gil B. (2018). Early adipose deposits in sheep: comparative analysis of the perirenal fat transcriptome of Assaf and Churra suckling lambs. Anim. Genet., 49: 605–617.
Search in Google Scholar Back to article
Sun Y., Chen X., Qin J., Liu S., Zhao R., Yu T., Chu G., Yang G., Pang W. (2018). Comparative Analysis of Long Noncoding RNAs Expressed during Intramuscular Adipocytes Adipogenesis in Fat-Type and Lean-Type Pigs. J. Agric. Food Chem., 66(45): 12122–12130.
Search in Google Scholar Back to article
Sun Y., Cai R., Wang Y., Zhao R., Qin J., Pang W. (2020). A Newly Identified LncRNA LncIMF4 Controls Adipogenesis of Porcine Intramuscular Preadipocyte through Attenuating Autophagy to Inhibit Lipolysis. Animals, 10(6): 926.
Search in Google Scholar Back to article
Tan L., Chen Z., Teng M., Chen B., Xu H. (2022). Genome-wide analysis of mRNAs, lncRNAs, and circRNAs during intramuscular adipogenesis in Chinese Guizhou Congjiang pigs. PLoS One, 17(1): e0261293.
Search in Google Scholar Back to article
Tian W., Wang Z., Wang D., Zhi Y., Dong J., Jiang R., Han R., Li Z., Kang X., Li H., Liu X. (2021). Chromatin Interaction Responds to Breast Muscle Development and Intramuscular Fat Deposition Between Chinese Indigenous Chicken and Fast-Growing Broiler. Front. Cell Dev. Biol., 9: 782268.
Search in Google Scholar Back to article
Tian W., Hao X., Nie R., Ling Y., Zhang B., Zhang H., Wu C. (2022). Comparative Transcriptome Analysis Reveals Regulatory Mechanism of Long Non-Coding RNAs during Abdominal Preadipocyte Adipogenic Differentiation in Chickens. Animals, 12(9): 1099.
Search in Google Scholar Back to article
Tianyi, L., Hui F., Salsabeel Y., Lingli X., Xiangyang M. (2022). Diferential regulation of mRNAs and lncRNAs related to lipid metabolism in Duolang and Small Tail Han sheep. Sci. Rep., 12:11157.
Search in Google Scholar Back to article
Wang J., Hua L., Chen J., Zhang J., Bai X., Gao B., Li C., Shi Z., Sheng W., Gao Y., Xing B. (2017). Identification and characterization of long non-coding RNAs in subcutaneous adipose tissue from castrated and intact full-sib pair Huainan male pigs. BMC Genomics, 18: 542.
Search in Google Scholar Back to article
Wang G.Z., Du K., Hu S.Q., Chen S.Y., Jia X.B., Cai M.C., Shi Y., Wang J., Lai S.J. (2018). Genome-wide identification and characterization of long non-coding RNAs during postnatal development of rabbit adipose tissue. Lipids Health Dis., 17: 271.
Search in Google Scholar Back to article
Wang J., Ren Q., Hua L., Chen J., Zhang J., Bai H., Li H., Xu B., Shi Z., Cao H., Xing B., Bai X. (2019). Comprehensive Analysis of Differentially Expressed mRNA, lncRNA and circRNA and Their ceRNA Networks in the Longissimus Dorsi Muscle of Two Different Pig Breeds. Int. J. Mol. Sci., 20(5): 1107.
Search in Google Scholar Back to article
Wang J., Chen M.Y., Chen J.F., Ren Q.L., Zhang J.Q., Cao H., Xing B.S., Pan C.Y. (2020a). LncRNA IMFlnc1 promotes porcine intramuscular adipocyte adipogenesis by sponging miR-199a-5p to up-regulate CAV-1. BMC Mol. Cell Biol., 21: 77.
Search in Google Scholar Back to article
Wang L., Li J., Hou X., Yan H., Zhang L., Liu X., Gao H., Zhao F., Wang L. (2020b). Genome-Wide Identification of RNA Editing Sites Affecting Intramuscular Fat in Pigs. Animals, 10; 1616.
Search in Google Scholar Back to article
Wang L., Xie Y., Chen W., Zhang Y., Zeng Y. (2021). The role of long noncoding RNAs in livestock adipose tissue deposition — A review. Anim. Biosci., 34(7): 1089-1099.
Search in Google Scholar Back to article
Wang L., Xie Y., Chen W., Zhang Y., Zeng Y. (2022). Identification and functional prediction of long noncoding RNAs related to intramuscular fat content in Laiwu pigs. Anim. Biosci., 35(1): 115-125.
Search in Google Scholar Back to article
Wang Z., Chai J., Wang Y., Gu Y., Long K., Li M., Jin L. (2023). LncPLAAT3-AS Regulates PLAAT3-Mediated Adipocyte Differentiation and Lipogenesis in Pigs through miR-503-5p. Genes, 14: 161.
Search in Google Scholar Back to article
Wei S., Li A., Zhang L., Du M. (2019). Growth and development symposium: stem and progenitor cells in animal growth: Long noncoding RNAs in adipogenesis and adipose development of meat animals. J. Anim. Sci.. 97(6): 2644–2657.
Search in Google Scholar Back to article
Xiao C., Wei T., Liu L.X., Liu J.Q., Wang C.X., Yuan Z.Y., Ma H.H., Jin H.G., Zhang L.C., Cao Y. (2021). Whole-Transcriptome Analysis of Preadipocyte and Adipocyte and Construction of Regulatory Networks to Investigate Lipid Metabolism in Sheep. Front. Genet., 12: 662143.
Search in Google Scholar Back to article
Xing K., Wang K., Ao H., Chen S., Tan Z., Wang Y., Xitong Z., Yang T., Zhang F., Iiu Y., Ni, H., Sheng X., Qi X., Wang X., Guo Y., Wang C. (2019). Comparative adipose transcriptome analysis digs out genes related to fat deposition in two pig breeds. Sci. Rep., 9: 12925.
Search in Google Scholar Back to article
Yang X.M., Liang Y., Zhong Z.J., Tao X., Yang Y.K., Zhang P., Wang Y., Lei Y.F., Chen X.H., Zeng K., Gong J.J., Ying S.C., Zhang J.L., Pang J.H., Lv X.B., Gu Y.R., He Z.P. (2021). Comparison of long non-coding RNAs in adipose and muscle tissues between seven indigenous Chinese and the Yorkshire pig breeds. Anim. Genet., 52, 645–655.
Search in Google Scholar Back to article
Yu S., Wang G., Liao J., Shen X., Chen J., Chen X. (2023). Co-expression analysis of long non-coding RNAs and mRNAs involved in intramuscular fat deposition in Muchuan black-bone chicken. Br. Poult. Sci., 64(3): 289-298.
Search in Google Scholar Back to article
Yue Y., Ge Z., Guo Z., Wang Y., Yang G., Sun S., Li X. (2023). Screening of lncRNA profiles during intramuscular adipogenic differentiation in longissimus dorsi and semitendinosus muscles in pigs. Anim. Biotech., 34(9): 4616–4626.
Search in Google Scholar Back to article
Zhai B., Zhao Y., Fan S., Yuan P., Li H., Li S., Li Y., Zhang Y., Huang H., Li H., Kang X., Li G. (2021). Differentially Expressed lncRNAs Related to the Development of Abdominal Fat in Gushi Chickens and Their Interaction Regulatory Network. Front. Genet., 12: 802857.
Search in Google Scholar Back to article
Zhang T., Zhang X., Han K., Zhang G., Wang J., Xie K., Xue Q., Fan X. (2017). Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken. PLoS One 12(2): e0172389.
Search in Google Scholar Back to article
Zhang M., Li F., Sun J.-W., Li D.H., Li W.T., Jiang R.R., Li Z.J., Liu,X.J., Han R.L., Li G.X., Wang Y.B., Tian Y.D., Kang X.T., Sun, G.R. (2019a). LncRNA IMFNCR Promotes Intramuscular Adipocyte Differentiation by Sponging miR-128-3p and miR-27b-3p. Front. Genet., 10: 42.
Search in Google Scholar Back to article
Zhang X., Hong R., Chen W., Xu M., Wang L. (2019b). The role of long noncoding RNA in major human disease. Bioorg. Chem., 92: 103214.
Search in Google Scholar Back to article
Zhang M., Ma X., Zhai Y., Zhang D., Sui L., Li W., Jiang R., Han R., Li G., Li Z., Wang Y., Tian Y., Kang X., Sun G. (2020a). Comprehensive Transcriptome Analysis of lncRNAs Reveals the Role of lncAD in Chicken Intramuscular and Abdominal Adipogenesis. J. Agric. Food Chem., 68: 3678−3688.
Search in Google Scholar Back to article
Zhang Z., Meng Y., Gao F., Xiao Y., Zheng Y., Wang H.Q., Gao Y., Jiang H., Yuan B., Zhang J.B. (2020b). TGF-β1-Mediated FDNCR1 Regulates Porcine Preadipocyte Differentiation via the TGF-β Signaling Pathway. Animals, 10(8): 1399.
Search in Google Scholar Back to article
Zhang S., Kang Z., Cai H., Jiang E., Pan C., Dang R., et al. (2021). Identification of novel alternative splicing of bovine lncRNA lncFAM200B and its effects on preadipocyte proliferation. J. Cell Physiol., 236(1): 601–611.
Search in Google Scholar Back to article
Zhang J., Wang J., Ma C., Wang W., Wang H., Jiang Y. (2022a). Comparative Transcriptomic Analysis of mRNAs, miRNAs and lncRNAs in the Longissimus dorsi Muscles between Fat-Type and Lean-Type Pigs. Biomolecules, 12(9): 1294.
Search in Google Scholar Back to article
Zhang R. M., Pan Y., Zou C. X., An Q., Cheng J. R., Li P. J., Zheng Z. H., Pan Y., Feng W. Y., Yang S. F., Shi D. S., Wei Y. M., Deng Y. F. (2022b). CircUBE2Q2 promotes diferentiation of cattle muscle stem cells and is a potential regulatory molecule of skeletal muscle development. BMC Genomics, 23: 267.
Search in Google Scholar Back to article
Zhang S., Xu H., Jiang E., Akhatayeva Z., Jiang F., Song E., Pan C., Chen H., Lan X. (2022c). Screening of Bovine Tissue-Specific Expressed Genes and Identification of Genetic Variation Within an Adipose Tissue-Specific lncRNA Gene. Front. Vet. Sci., 9: 887520.
Search in Google Scholar Back to article
Zhang X., Liu Ch., Kong Y., Li F., Yue X. (2022d). Effects of intramuscular fat on meat quality and its regulation mechanism in Tan sheep. Front. Nutr., 9: 908355.
Search in Google Scholar Back to article
Zhang W., Wang J., Li, B., Sun B., Yu S., Wang X., Zan L. (2023). Long Non-Coding RNA BNIP3 Inhibited the Proliferation of Bovine Intramuscular Preadipocytes via Cell Cycle. Int. J. Mol. Sci., 24(4): 4234.
Search in Google Scholar Back to article
Zhang D., Ma X., Li H., Li X., Wang J., Zan L. (2024). SERPINE1AS2 regulates intramuscular adipogenesis by inhibiting PAI1 protein expression. Int. J. Biol. Macromol., 275: 133592.
Search in Google Scholar Back to article
Zhang W., Raza S.H.A., Li B., Yang W., Khan R., Aloufi B.H., Zhang G., Zuo F., Zan L. (2024). LncBNIP3 Inhibits Bovine Intramuscular Preadipocyte Differentiation via the PI3K-Akt and PPAR Signaling Pathways Agric. Food Chem., 72: 24260−24271.
Search in Google Scholar Back to article
Zhao T., Hu Y., Peng J., Cheng L. (2020). DeepLGP: a novel deep learning method for prioritizing lncRNA target genes. Bioinformatics, 36(16): 4466-4472.
Search in Google Scholar Back to article
Zhao Y., Chen S., Yuan J., Shi Y., Wang Y., Xi Y., Qi X., Guo Y., Sheng X., Liu J., Zhou L., Wang C., Xing K. (2023). Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory Network for Intramuscular Fat in Pigs. Genes. 14(1): 168.
Search in Google Scholar Back to article

The role of long non-coding RNAs in intramuscular fat deposition in livestock: Current research

Abstract

Paradigm

My account