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Bipolar affective disorder - Clinical manifestations and treatment approaches Cover

Bipolar affective disorder - Clinical manifestations and treatment approaches

By: Mariana Sîrbu and  Alina Bologan  
Open Access
|Jun 2025

Abstract

Introduction: Bipolar affective disorder is a chronic psychiatric illness characterized by alternating episodes of elevated and depressed mood. Its clinical presentation varies widely, requiring a nuanced diagnostic approach. Differentiating between type one and type two forms remains essential for appropriate treatment planning.

Presentation of case series: This case series describes three patients diagnosed with bipolar affective disorder, each presenting distinct clinical patterns. The first patient exhibited a classic manic episode with psychotic features, requiring inpatient stabilization and combination pharmacotherapy. The second case involved a depressive episode with a prior history of hypomania, consistent with bipolar type two. The third patient presented a mixed episode marked by agitation, emotional instability, and suicidal ideation. All cases included a family history of mood disorders, supporting genetic predisposition. Therapeutic interventions consisted of mood stabilizers, antipsychotics, and psychoeducation. Clinical evolution was favorable in patients with high adherence and social support.

Conclusions: Bipolar affective disorder presents with diverse and sometimes atypical symptoms. Early recognition and accurate subtype differentiation are crucial for effective management. Case-based observation highlights the importance of individualized treatment, psychosocial support, and long-term monitoring.

DOI: https://doi.org/10.2478/amma-2025-0020 | Journal eISSN: 2668-7763 | Journal ISSN: 2668-7755
Language: English
Page range: 163 - 167
Submitted on: Mar 25, 2025
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Accepted on: May 5, 2025
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Published on: Jun 30, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Mariana Sîrbu, Alina Bologan, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.