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Clostridium Difficile Infection in Childhood: Case Series

Open Access
|May 2025

References

  1. Borali E, De Giacomo C. Clostridium Dinjcile Infection in Children: A Review. J Pediatr Gastroenterol Nutr. 2016;63(6):e130-e140.
  2. Shirley DA, Tornel W, Warren CA, Moonah S. Clostridioides difficile Infection in Children: Recent Updates on Epidemiology, Diagnosis, Therapy. Pediatrics. 2023;152(3):e2023062307.
  3. Czepiel J, Dróżdż M, Pituch H, et al. Clostridium dinjcile infection: review. Eur J Clin Microbiol Infect Dis. 2019;38(7):1211-1221.
  4. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium dinjcile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31(5):431-455.
  5. Rupnik M, Wilcox MH, Gerding DN. Clostridium dinjcile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol. 2009;7(7):526-536.
  6. Dop D, Marcu IR, Padureanu V, et al. Clostridium dinjcile infection in pediatric patients (Review). Biomed Rep. 2023;20(2):18. Published 2023 Dec 8.
  7. Tougas SR, Lodha N, Vandermeer B, et al. Prevalence of Detection of Clostridioides dinjcile Among Asymptomatic Children: A Systematic Review and Meta-analysis. JAMA Pediatr. 2021;175(10):e212328.
  8. Anjewierden S, Han Z, Foster CB et al. Risk factors for Clostridium dinjcile infection in pediatric inpatients: A meta-analysis and systematic review. Infect Control Hosp Epidemiol. 2019;40(4):420-426.
  9. Adams DJ, Eberly MD, Rajnik M, Nylund CM. Risk Factors for Community-Associated Clostridium dinjcile Infection in Children. J Pediatr. 2017; 186:105-109.
  10. Al-Rawahi GN, Al-Najjar A, McDonald R, et al. Pediatric oncology and stem cell transplant patients with healthcare-associated Clostridium dinjcile infection were already colonized on admission. Pediatr Blood Cancer. 2019;66(5):e27604.
  11. Kim J, Smathers SA, Prasad P, et al. Epidemiological features of Clostridium dinjcile-associated disease among inpatients at children’s hospitals in the United States, 2001-2006. Pediatrics. 2008;122(6):1266-1270.
  12. Zilberberg MD, Tillotson GS, McDonald C. Clostridium dinjcile infections among hospitalized children, United States, 1997-2006. Emerg Infect Dis. 2010;16(4):604-609.
  13. Stoesser N, Eyre DW, Quan TP, et al. Epidemiology of Clostridium dinjcile in infants in Oxfordshire, UK: Risk factors for colonization and carriage, and genetic overlap with regional C. dinjcile infection strains. PLoS One. 2017;12(8):e0182307. Published 2017 Aug 16.
  14. Shim JO. Clostridium dinjcile in Children: To Treat or Not to Treat?. Pediatr Gastroenterol Hepatol Nutr. 2014;17(2):80-84. doi:10.5223/pghn.2014.17.2.80
  15. Nylund CM, Goudie A, Garza JM, et al. Clostridium dinjcile infection in hospitalized children in the United States. Arch Pediatr Adolesc Med. 2011;165(5):451-457.
  16. Toltzis P, Kim J, Dul M, et al. Presence of the epidemic North American Pulsed Field type 1 Clostridium dinjcile strain in hospitalized children. J Pediatr. 2009;154(4):607-608.
  17. Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium dinjcile-associated diarrhea with high morbidity and mortality [published correction appears in N Engl J Med. 2006 May 18;354(20):2200]. N Engl J Med. 2005;353(23):2442-2449.
  18. Carroll KC, Mizusawa M. Laboratory tests for the diagnosis of Clostridium dinjcile. Clin Colon Rectal Surg. 2020;33:073-081.
  19. McDonald LC, Gerding DN, Johnson S, et al. Clinical Practice Guidelines for Clostridium dinjcile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(7):e1-e48.
  20. Song PH, Min JH, Kim YS, et al. Rapid and accurate diagnosis of Clostridium dinjcile infection by real-time polymerase chain reaction. Intest Res. 2018;16(1):109-115.
  21. Wolf J, Kalocsai K, Fortuny C, et al. Safety and Enjcacy of Fidaxomicin and Vancomycin in Children and Adolescents with Clostridioides (Clostridium) dinjcile Infection: A Phase 3, Multicenter, Randomized, Single-blind Clinical Trial (SUN-SHINE). Clin Infect Dis. 2020;71(10):2581-2588.
  22. Ng QX, Loke W, Foo NX, et al. A systematic review of the use of rifaximin for Clostridium dinjcile infections. Anaerobe. 2019; 55:35-39.
  23. El Feghaly RE, Stauber JL, Tarr PI, Haslam DB. Viral co-infections are common and are associated with higher bacterial burden in children with clostridium dinjcile infection. J Pediatr Gastroenterol Nutr. 2013;57(6):813-816.
  24. Mullish BH, Williams HR. Clostridium dinjcile infection and antibiotic-associated diarrhoea. Clinical Medicine. 2018;18(3):237–241.
  25. Morinville V, McDonald J. Clostridium dinjcile-associated diarrhea in 200 Canadian children. Can J Gastroenterol. 2005;19(8):497-501.
  26. Kuiper GA, van Prehn J, Ang W, et al. Clostridium difficile infections in young infants: Case presentations and literature review. IDCases. 2017; 10:7-11. Published 2017 Jul 24.
  27. Gogate A, De A, Nanivadekar R, et al. Diagnostic role of stool culture & toxin detection in antibiotic associated diarrhoea due to Clostridium dinjcile in children. Indian J Med Res. 2005;122(6):518-524.
  28. Perumalsamy S, Lim SC, Riley TV. Clostridioides (Clostridium) dinjcile isolated from paediatric patients in Western Australia 2019-2020. Pathology. 2022;54(4):460-465.
  29. Schutze GE, Willoughby RE; Committee on Infectious Diseases; American Academy of Pediatrics. Clostridium dinjcile infection in infants and children. Pediatrics. 2013;131(1):196-200.
  30. Guarino A, Ashkenazi S, Gendrel D, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence- based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014;59(1):132-152.
DOI: https://doi.org/10.2478/amb-2025-0034 | Journal eISSN: 2719-5384 | Journal ISSN: 0324-1750
Language: English
Page range: 98 - 103
Submitted on: Oct 15, 2024
Accepted on: Nov 22, 2024
Published on: May 15, 2025
Published by: Sofia Medical University
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 P. Parusheva, L. Pekova, S. Angelova, B. Bureva, published by Sofia Medical University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.