Clostridium Difficile Infection in Childhood: Case Series
Abstract
Clostridioides (formerly Clostridium) difficile is a spore-forming, anaerobic, toxin- producing gram-positive bacillus. Recently, its frequency as a cause of diarrhea in childhood has been increasing, which necessitates its further in-depth study.
Objective
To analyze the risk factors for morbidity, clinical course and outcome in children with C. difficile infection (CDI). A series of six cases of CDI in children aged between 10 months and 11 years, hospitalized in the Clinic for Infectious Diseases at University hospital, Stara Zagora, is presented. The main clinical manifestation of the disease is a diarrheal syndrome. All of the patients underwent clinical, epidemiological, laboratory, microbiological and serological tests.
Conclusion
The age group in our study is different from the usual one for CDI. With the exception of one, all the remaining patients lacked predisposing factors for CDI. Rapid diagnosis and initiation of adequate etiological therapy improves the condition of patients and leads to a favorable outcome.
© 2025 P. Parusheva, L. Pekova, S. Angelova, B. Bureva, published by Sofia Medical University
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