Association of X Chromosome Aberrations with Male Infertility

S. Xharra; E. Behluli; A. Moder; H. Nefic; R. Hadziselimovic; G. Temaj

doi:10.2478/amb-2021-0051

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Association of X Chromosome Aberrations with Male Infertility

Acta Medica Bulgarica

Volume 48 (2021): Issue 4 (November 2021)

By: S. Xharra, E. Behluli, A. Moder, H. Nefic, R. Hadziselimovic and G. Temaj

Open Access

|Nov 2021

Abstract

Male infertility is caused by spermatogenetic failure, clinically noted as oligoor azoospermia. Approximately 20% of infertile patients carry a genetic defect. The most frequent genetic defect leading to azoospermia (or severe oligozoospermia) is Klinefelter syndrome (47, XXY), which is numerical chromosomal abnormality and Y- structural chromosome aberration. The human X chromosome is the most stable of all human chromosomes. The X chromosome is loaded with regions of acquired, rapidly evolving genes. The X chromosome may actually play an essential role in male infertility and sperm production. Here we will describe X chromosome aberrations, which are associated with male infertility.

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Articles in this issue

DOI: https://doi.org/10.2478/amb-2021-0051 | Journal eISSN: 2719-5384 | Journal ISSN: 0324-1750

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Language: English

Page range: 69 - 72

Submitted on: Aug 11, 2020

Accepted on: Sep 22, 2020

Published on: Nov 20, 2021

Published by: Medical University - Sofia

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

Klinefelter syndrome,

azoospermia,

chromosome aberration,

Related subjects:

Basic medical science,

Immunology,

Clinical medicine,

Clinical medicine, other

© 2021 S. Xharra, E. Behluli, A. Moder, H. Nefic, R. Hadziselimovic, G. Temaj, published by Medical University - Sofia
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 48 (2021): Issue 4 (November 2021)