Association of X Chromosome Aberrations with Male Infertility

Xharra, S.; Behluli, E.; Moder, A.; Nefic, H.; Hadziselimovic, R.; Temaj, G.

doi:10.2478/amb-2021-0051

Abstract

Male infertility is caused by spermatogenetic failure, clinically noted as oligoor azoospermia. Approximately 20% of infertile patients carry a genetic defect. The most frequent genetic defect leading to azoospermia (or severe oligozoospermia) is Klinefelter syndrome (47, XXY), which is numerical chromosomal abnormality and Y- structural chromosome aberration. The human X chromosome is the most stable of all human chromosomes. The X chromosome is loaded with regions of acquired, rapidly evolving genes. The X chromosome may actually play an essential role in male infertility and sperm production. Here we will describe X chromosome aberrations, which are associated with male infertility.

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Association of X Chromosome Aberrations with Male Infertility

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