Summary of the key features of AdV-D24-ICOSL-CD40L and Ad5/3-D24-GM-CSF_
| Oncolytic Adenovirus | Tumor Selectivity | Transgenes | Studies | Major results |
|---|---|---|---|---|
| AdV5/3-D24-ICOSL-CD40L | Yes (E1A deletion) | ICOSL and CD40L for enhanced T-cell costimulation | Preclinical mesothelioma models (both in vitro and in vivo) | Safety profile, enhances efficacy, ICD, T-cell infiltration |
| Ad5/3-D24-GM-CSF (ONCOS-102) | GM-CSF for improved antigen presentation | Phase I/II in mesothelioma (NCT02963831) | T-cell infiltration, safety profile, improved efficacy |