Nimbolide Reduces Inflammation and Oxidative Stress to Inhibit Disease Progression in Septic Acute Kidney Injury Mice
By: Yihua Yu, Yangling Li and Ying Gong
References
- Annaldas S, Saifi MA, Khurana A et al. (2019) Nimbolide ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibition of TGF-β and EMT/Slug signalling. Mol Immunol 112:247–255.
https://doi.org/10.1016/j.molimm.2019.06.003 - Ba J, Lin Y, Zhang J et al. (2025) Nimbolide targeting SIRT1 protects against acetaminophen-induced acute liver injury by regulating oxidative stress and endoplasmic reticulum stress. Pharmacol Res Perspect 13:e70120.
https://doi.org/10.1002/prp2.70120 - Jiang J, Hu B, Chung CS et al. (2020) SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model. Mol Med 26:89.
https://doi.org/10.1186/s10020-020-00210-1 - Li N, Lin G, Zhang H et al. (2023) Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. Biochem Pharmacol 211:115523.
https://doi.org/10.1016/j.bcp.2023.115523 - Li H, Ren Q, Hu Y et al. (2024) SKLB023 protects against inflammation and apoptosis in sepsis-associated acute kidney injury via the inhibition of Toll-like receptor 4 signaling. Int Immunopharmacol 139:112668.
https://doi.org/10.1016/j.intimp.2024.112668 - Liu AB, Tan B, Yang P et al. (2024) The role of inflammatory response and metabolic reprogramming in sepsis-associated acute kidney injury: Mechanistic insights and therapeutic potential. Front Immunol 15:1487576.
https://doi.org/10.3389/fimmu.2024.1487576 - Lou Y, Shi H, Sha N et al. (2025) Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway. BMC Nephrol 26:45.
https://doi.org/10.1186/s12882-025-03977-9 - Ma Y, Xu S, Meng J et al. (2022) Protective effect of nimbolide against streptozotocin induced gestational diabetes mellitus in rats via alteration of inflammatory reaction, oxidative stress, and gut microbiota. Environ Toxicol 37:1382–1393.
https://doi.org/10.1002/tox.23491 - Mou L, Yang L, Hou S et al. (2023) Structure-activity relationship studies of 2,4,5-trisubstituted pyrimidine derivatives leading to the identification of a novel and potent sirtuin 5 inhibitor against sepsis-associated acute kidney injury. J Med Chem 66: 11517–11535.
https://doi.org/10.1021/acs.jmedchem.3c01031 - Pooladanda V, Thatikonda S, Bale S et al. (2019) Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation. Cell Death Dis 10:81.
https://doi.org/10.1038/s41419-018-1247-9 - Ren Q, Guo F, Tao S et al. (2020) Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice. Biomed Pharmacother 122:109772.
https://doi.org/10.1016/j.biopha.2019.109772 - Şahin N, Bora ES, Çınaroğlu OS et al. (2025) Rho-associated kinase inhibitor fasudil protects from sepsis-induced acute kidney injury in rat via suppressing STAT-3 and NLRP-3 pathway. Curr Issues Mol Biol 47:340.
https://doi.org/10.3390/cimb47050340 - Senousy SR, Ahmed AF, Abdelhafeez DA et al. (2022) Alpha-chymotrypsin protects against acute lung, kidney, and liver injuries and increases survival in CLP-induced sepsis in rats through inhibition of TLR4/NF-κB pathway. Drug Des Devel Ther 16:3023–3039.
https://doi.org/10.2147/DDDT.S370460 - Shu X, Hu Y, Huang C et al. (2021) Nimbolide ameliorates the streptozotocin-induced diabetic retinopathy in rats through the inhibition of TLR4/NF-κB signaling pathway. Saudi J Biol Sci 28:4255–4262.
https://doi.org/10.1016/j.sjbs.2021.06.039 - Teng Y, Huang Y, Yu H et al. (2023) Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling. Acta Pharm Sin B 13:2269–2280.
https://doi.org/10.1016/j.apsb.2023.02.018 - Wang X, Li J, Yu B et al. (2026) Nimbolide inhibits NLRP3 inflammasome activation via blocking NEK7-NLRP3 interaction and alleviates sepsis-induced lung injury. Int Immunopharmacol 168(Pt 2):115954.
https://doi.org/10.1016/j.intimp.2025.115954 - Wang HW, Wu MM, Zhu MM et al. (2025) Growth differentiation factor 11 attenuates sepsis-associated acute kidney injury by reducing inflammation and coagulation via PGC-1α/Nrf2 activation. Cell Mol Biol Lett 30:102.
https://doi.org/10.1186/s11658-025-00762-2 - Xia YM, Guan YQ, Liang JF et al. (2024) TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway. Ren Fail 46:2313176.
https://doi.org/10.1080/0886022X.2024.2313176 - Zhang R, Su K, Yang L et al. (2023) Design, synthesis, and biological evaluation of novel P2X7 receptor antagonists for the treatment of septic acute kidney injury. J Med Chem 66:11365–11389.
https://doi.org/10.1021/acs.jmedchem.3c00837
DOI: https://doi.org/10.2478/aite-2026-0023 | Journal eISSN: 1661-4917
Language: English
Submitted on: Mar 31, 2026
Accepted on: Jul 10, 2026
Published on: Aug 22, 2026
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
Related subjects:
© 2026 Yihua Yu, Yangling Li, Ying Gong, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.