| Jorizzo et al. (1983) | F, 53; disseminated leiomyosarcoma | UC diagnosed simultaneously with BADAS | Erythematous papulovesicular, papulopustules with purpuric bases | Fever, arthralgia, oligoarthritis | Unknown | Leukocytosis, anemia; pancolitis | PRED |
| Fenske et al. (1983) | M, 32; none | UC diagnosed simultaneously with BADAS | Vesicles and pustules with necrosis | Fever | Weight loss, abdominal cramping, watery diarrhea | Leukocytosis; colitis | PRED, SSZ |
| Jorizzo et al. (1984) | F, 42; None | CD unknown | Erythematous pustules | Polyarthralgia | Unknown | Unknown | Colectomy, no additional therapy |
| Delaney et al. (1989) | M, 46; none | CD diagnosed 1 year before the first symptoms of BADAS | Erythematous macules, vesicopustules | Fever, arthritis | Weight loss, perianal ulceration | Leukocytosis, accelerated ESR; unknown | Underwent proctocolectomy, PRED, Cloxacillin, AZA |
| Matheson et al. (1996) | F, 16; none | CD diagnosed simultaneously with BADAS | Erythematous, maculopapular, plaques, lesions with pruritis | Fever | Weight loss, abdominal pain, hematemesis, hematochezia | Leukocytosis, accelerated ESR; deep ulcerations in anus, rectum | MP, oral H1 antagonists, topical corticosteroids |
| Vázquez et al. (2003) | M, 34; none | UC was diagnosed 12 years before the first symptoms of BADAS | Erythematous plaques, pustules | Fever | Severe diarrhea, abdominal pain | In normal ranges; diagnosis of IBD | PRED, SSZ |
| Mendoza et al. (2003) | F, 63; episcleritis | CD diagnosed simultaneously with BADAS | Erythematous plaques, nodules, vesicopustules | Fever, asymmetrical polyarthralgia | Weight loss, abdominal pain, mucosal stool movement | Anemia; multiple deep, wide ulcers alternating with normal mucosal from the sigmoid colon and ascending 70 cm | MP |
| Guerre-Schmidt et al. (2006) | F, 13, none | CD diagnosed simultaneously with BADAS | Erythematous pustules | Fever, oligoarthritis | Weight loss, rectal bleeding | Anemia, elevated CRP; ulcerated appearance of area of appendix | PRED |
| Ashok and Kiely (2007) | M, 23, none | CD was diagnosed 4 years before the first BADAS symptoms | Erythematous macules, papules, vesicopustular | Fever, arthritis, arthralgia, malaise | Stomal diarrhea, abdominal pain, vomiting | Leucocytosis, accelerated ESR, elevated CRP; unknown | PRED |
| Kinyó et al. (2011) | M, 32, none | CD diagnosed simultaneously with BADAS | Vesiculopustu les on erythematous base | Fever, arthritis | Bloody diarrhea | Leucocytosis, accelerated ESR, elevated CRP; Pancolitis. An ulcerated, granulomatous with abscess formation | MP, Metronidaz ole, cefuroxime, CsA, AZA |
| Lacey et al. (2011) | F, 24, none | UC diagnosed simultane ously with BADAS | Pustular lesions, non-tender | Fever, malaise | Abdominal pain, diarrhea, hematochezia | Leucocytosis; Severe UC | MP pulses, Metronidazole, Ciprofl oxacin, PRED, AZA |
| Truchuelo et al. (2013) | F, 35, none | UC diagnosed previous than BADAS | Erythematous plaques, nodules, vesicopustules with erythematous halo, painful | Fever, polyarthritis, malaise | Asthenia | Accelerated ESR; unknown | PRED, metronidazole |
| DeFilippis et al. (2014) | F, 64; depression, osteoporosis, spinal stenosis | UC was diagnosed 20 years before the first | Erythematous-violaceous macules | Arthralgia, arthritis | Abdominal pain, diarrhea | Accelerated ESR, elevated CRP; active microscopic inflammation on a right colon | PRED, MMF, SSZ |
| DeFilippis et al. (2014) | F, 64; depression, osteoporosis, spinal stenosis, gastroesophageal reflux | UC was diagnosed 20 years before the first symptoms of BADAS | Erythematous-violaceous macules | Arthralgia, arthritis | Abdominal pain, diarrhea | Accelerated ESR, elevated CRP; active microscopic inflammation on a right colon | Infliximab, MMF, SSZ |
| Aounallah et al. (2016) | F, 39, unknown | UC diagnosed previous than BADAS | Vesicles and pustules | Fever, arthralgia | Unknown | Unknown | PRED, AZA, CsA |
| Oldfield et al. (2016) | F, 4, sickle cell disease, autoimmune hepatitis | UC diagnosed previous than BADAS | Hemorrhagic vesicles | Fever, arthritis, malaise | Abdominal pain, congestion, hematochezia | Leucocytosis, anemia, elevated CRP; unknown | PRED, Metronidazole, Mesalazine, AZA, infliximab |
| Barland et al. (2016) | F, 42, unknown | CD was diagnosed 10 years before the first symptoms of BADAS | Erythematous nodules, vesiculopustules | Arthalgia | Unknown | Anemia, elevated CRP; unknown | Mesalazine, doxycycline |
| Heard et al. (2020) | F, 49, depression, anxiety, mitral valve prolapse, stroke | CD was diagnosed earlier than the onset of BADAS, but the date is unknown | Erythematous vesiculopustule, erosions | Fever, arthralgia | Diarrhea, rectal bleeding, dehydration | Anemia; severe ulceration in rectum and sigmoid | Piperacillin + tazobactam, ustekinumab |
| Havele et al. (2021) | M, 6, immune dysfunction, recurrent fever, uveitis | VEO-IBD diagnosed simultaneously with BADAS | Erythematous papules, vesiculopustules tender | Fever, arthralgia | Increase rectal output, vomiting, oral ulcers | Unknown | Infliximab, cedolizuma b, canakinum ab, mesalazine, ileostomy |
| Havele et al. (2021) | M, 6, Immune dysfunction, recurrent fever, uveitis | VEO-IBD diagnosed simultaneously with BADAS | Erythematous papules, vesiculopustules tender | Fever, arthralgia | Increase rectal output, vomiting, oral ulcers | Unknown | Triamcinol one topical |
| Havele et al. (2021) | M, 6, immune dysfunction, recurrent fever, uveitis | VEO-IBD diagnosed simultaneously with BADAS | Erythematous papules, vesiculopustules tender | Fever, arthalgia | Increase rectal output, vomiting, oral ulcers | Unknown | Subtotal colectomy, triamcinol one topical, ruxolitinib |
| Caro et al. (2021) | F, 78, erythema nodosum | UC diagnosed simultaneously with BADAS | Erythematous and purple plaques, nodules, | Arthralgia, arthritis | Abdominal pain, diarrhea, tenesmus, mucus in stool | accelerated ESR, elevated CRP; a recto sigmoid UC | Mesalazine, rifaximin |
| Russell Johns et al. (2022) | F, 14; none | UC diagnosed simultaneously with BADAS | Violaceous nodules, indurated plaques, painful, | Fever, migratory arthritis, malaise | Abdominal cramping, bloody diarrhea | Leucocytosis, anemia, accelerated ESR, elevated CRP; eosinophilic colitis from the rectum to the sigmoid colon | MP pulses, followed by PRED + SS Z followed by infliximab + SSZ |
| Alshahrani et al. (2022) | M, 39; none | UC was diagnosed 3 years before the symptoms of BADAS | Erythematous papular, maculopapular, urticaria-like, vesiculopustular lesions | Fever, Polyarteritis, Achilles tendinitis, malaise | Weight loss, bloody diarrhea, | Anemia, accelerated ESR, elevated CRP; hyperemia with mild edematous mucosal changes in the sigmoid colon | PRED, Mesalazine, Metronidaz ole, Fluoroquinolone, AZA |
| Case 1 (in our present publication) | F, 30; beta thalassemia | UC diagnosis in 2012, first symptoms of BADAS in 2017, BADAS diagnosis in 2021 | Edematous erythematous macules, maculopapular lesions | Fever, arthritis, arthralgia malaise | Bloody diarrhea | Anemia, elevated CRP, high D-dimer – 6478 ng/mL; unknown | PRED, Mesalazine, Cefuroxime, Fluoroquinolone, CsA, AZA |
| Case 2 (in our present publication) | M, 67; benign prostatic hyperplasia, osteoarthritis | CD diagnosed in 2020, BADAS diagnosed in 2023 | Edematous erythematous macules, maculopapular, vesicopustular lesions | Fever, arthritis, arthralgia | Abdominal pain, diarrhea, mucus in stool | Leucocytosis, anemia, elevated CRP, high D-dimer – 7200 ng/mL; the entire length of the sigmoid colon and the final section of the descending colon with a thickened, swollen wall | Metronidazole, PRED, ciprofloxacin, topical clobetasol propionate, infliximab |
