
Tissue-specific variability in protein expression of cytochrome P450 and glutathione S-transferase isoenzymes in non-small cell lung carcinoma
References
- Murray GI. The role of cytochrome P450 in tumour development and progression and its potential in therapy. J Pathol 2000;192:419–26. doi: 10.1002/1096-9896(2000)9999:9999:<;::AID-PATH750>3.0.CO;2-0
- Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005;45:51–88. doi: 10.1146/annurev.pharmtox.45.120403.095857
- Wang Z, Wu Y, Ding Z, Xiao X, Huang Y, Liu Z, Zhang Q. A novel mechanism for A-to-I RNA-edited CYP1A1 in promoting cancer progression in NSCLC. Cell Mol Biol Lett 2025;30(1):40. doi: 10.1186/s11658-025-00718-6
- Pan J, Huang G, Yin Z, Cai X, Gong E, Li Y, Xu C, Ye Z, Cao Z, Cheng W. Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1. Cancer Gene Ther 2022;29:101–21. doi: 10.1038/s41417-021-00293-w
- Gong E, Pan J, Ye Z, Cai X, Zheng H, Yin Z, Jiang Y, Wang X, Cao Z. Ganoderic acid A suppresses autophagy by regulating the circFLNA/miR-486-3p/CYP1A1/XRCC1 axis to strengthen the sensitivity of lung cancer cells to cisplatin. J Pharm Pharmacol 2024;76:354–67. doi: 10.1093/jpp/rgad116
- Lin H, Hu B, He X, Mao J, Wang Y, Wang J, Zhang T, Zheng J, Peng Y, Zhang F. Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin. Biochem Pharmacol 2020;171:113733. doi: 10.1016/j.bcp.2019.113733
- Oyama T, Sugio K, Uramoto H, Kawamoto T, Kagawa N, Nadaf S, Carbone D, Yasumoto K. Cytochrome P450 expression (CYP) in non-small cell lung cancer. Front Biosci 2007;12:2299–308. doi: 10.2741/2232
- Toussaint C, Albin N, Massaad L, Grunenwald D, Parise O Jr, Morizet J, Gouyette A, Chabot GG. Main drug- and carcinogen-metabolizing enzyme systems in human non-small cell lung cancer and peritumoral tissues. Cancer Res 1993;53:4608–12. PMID: 8402635
- Lin P, Chang H, Ho WL, Wu MH, Su JM. Association of aryl hydrocarbon receptor and cytochrome P4501B1 expressions in human non-small cell lung cancers. Lung Cancer 2003;42:255–61. doi: 10.1016/S0169-5002(03)00359-3
- Kivistö KT, Linder A, Friedel G, Beaune P, Belloc C, Kroemer HK, Fritz P. Immunohistochemical localization of cytochrome P450 2E1 in human pulmonary carcinoma and normal bronchial tissue. Virchows Arch 1995;426:243–7. doi: 10.1007/BF00191361
- Spivack SD, Hurteau GJ, Fasco MJ, Kaminsky LS. Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors. Clin Cancer Res 2003;9(16 Pt 1):6002–11. PMID: 14676126
- Sobin LH, Wittekind C, editors. TNM Classification of Malignant Tumours. 6th ed. New York (NY): Wiley-Liss; 2002.
- Sobin LH, Gospodarowicz MK, Wittekind C, editors. TNM Classification of Malignant Tumours. 7th ed. Chichester: Wiley-Blackwell; 2009.
- Oğuztüzün S, Aydın M, Demirağ F, Yazıcı U, Özhavzalı M, Kılıç M, İşcan M. The expression of GST isoenzymes and p53 in non-small cell lung cancer. Folia Histochem Cytobiol 2010;48:122–7. doi: 10.2478/v10042-008-0084-6
- Bulus H, Oguztuzun S, Guler Simsek G, Kilic M, Oguz Ada A, Gol S, Kaya Kocdogan A, Kaygin P, Bozer B, Iscan M. Expression of CYP and GST in human normal and colon tumor tissues. Biotech Histochem 2019;94:1–9. doi: 10.1080/10520295.2018.1493220
- Takci Z, Gunes Bilgili S, Kilic M, Oguztuzun S, Bozer B, Guler Simsek G, Akbayrak A, Yildiz Seckin H, Karadag AS. Expressions of glutathione S-transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea. J Cosmet Dermatol 2020;19:2070–5. doi: 10.1111/jocd.13501
- Kang J, Seo DS, Ahmad Y, Park S, Yoo J, Lee J, Baek S, Joo S, Kwon H, Bae HJ, Lee H, Kwon TK, Jang Y. Biological role of cytochrome P450 family 1 subfamily A member 1 (CYP1A1) in ketogenic diet-induced modulation of lung cancer. Life Sci 2025;378:123811. doi: 10.1016/j.lfs.2025.123811
- Słowikowski BK, Gałęcki B, Dyszkiewicz W, Jagodziński PP. Decreased expression of cytochrome P450 1B1 in non-small cell lung cancer. Biomed Phar macother 2017;95:339–45. doi: 10.1016/j.biopha.2017.08.056
- Jia L, Gao F, Hu G, Fang Y, Tang L, Wen Q, Gao N, Xu H, Qiao H. A novel cytochrome P450 2E1 inhibitor Q11 is effective on lung cancer via regulation of the inflammatory microenvironment. Adv Sci (Weinh) 2023;10(35):e2303975. doi: 10.1002/advs.202303975
- Di Pietro G, Magno LAV, Rios-Santos F. Glutathione S-transferases: an overview in cancer research. Expert Opin Drug Metab Toxicol 2010;6:153–70. doi: 10.1517/17425250903427980
- Okamura T, Antoun G, Keir ST, Friedman H, Bigner DD, Ali-Osman F. Phosphorylation of glutathione S-transferase P1 (GSTP1) by epidermal growth factor receptor (EGFR) promotes formation of the GSTP1–c-Jun N-terminal kinase (JNK) complex and suppresses JNK downstream signaling and apoptosis in brain tumor cells. J Biol Chem 2015;290:30866–78. doi: 10.1074/jbc.M115.656140
- Wang SQ, Chen JJ, Jiang Y, Lei ZN, Ruan YC, Pan Y, Yam JWP, Wong MP, Xiao ZJ. Targeting GSTP1 as therapeutic strategy against lung adenocarcinoma stemness and resistance to tyrosine kinase inhibitors. Adv Sci (Weinh) 2023;10(7):e2205262. doi: 10.1002/advs.202205262
- Bai F, Nakanishi Y, Kawasaki M, Takayama K, Yatsunami J, Pei XH, Tsuruta N, Wakamatsu K, Hara N. Immunohistochemical expression of glutathione S-transferase-Pi can predict chemotherapy response in patients with nonsmall cell lung carcinoma. Cancer 1996;78:416–21. doi: 10.1002/(SICI)1097-0142(19960801)78:3<;416::AID-CNCR6>3.0.CO;2-H
- Nakanishi Y, Kawasaki M, Bai F, Takayama K, Pei XH, Takano K, Inoue K, Osaki S, Hara N, Kiyohara C. Expression of p53 and glutathione S-transferase-pi relates to clinical drug resistance in non-small cell lung cancer. Oncology 1999;57:318–23. doi: 10.1159/000012068
- Crawford EL, Khuder SA, Durham SJ, Frampton M, Utell M, Thilly WG, Weaver DA, Ferencak WJ, Jennings CA, Hammersley JR, Olson DA, Willey JC. Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res 2000;60:1609–18. PMID: 10749130
DOI: https://doi.org/10.2478/aiht-2026-77-4112 | Journal eISSN: 1848-6312 (formerly 0004-1254) | Journal ISSN: 0004-1254
Language: English, Croatian
Page range: 190 - 197
Submitted on: Feb 1, 2026
Accepted on: Aug 1, 2026
Published on: Sep 25, 2026
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Keywords:
Related subjects:
© 2026 Murat Kılıç, Serpil Oğuztüzün, Sezgin Çelik, Funda Demirağ, Pınar Bıçakçıoğlu, Mümtaz İşcan, Ahmet Oğuz Ada, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution 4.0 License.