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Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase Cover

Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase

Archives of Industrial Hygiene and Toxicology
Volume 75 (2024): Issue 1 (March 2024)
By: ,   and    
Open Access
|Mar 2024
Figures & tables

Figures & Tables

Figure 1

Chemical structure of glyphosate

Figure 2

Glyphosate inhibition profiles for human AChE and BChE shown as the dissociation constant of the enzyme-inhibitor complex (Ki, upper panels) and IC50 values (lower panels) determined in the presence of substrate acetylthiocholine (ATCh) over a range of glyphosate concentrations (c). The same dataset was used to determine both kinetic profiles. Inhibition was evaluated from four experiments measured at 25 °C

Table 1

Dissociation constants (Ki) of glyphosate for human AChE and BChE and approximated IC50 values

EnzymeKi (mmol/L)Approx. IC50 (mmol/L)
AChE28.4±2.725.1
BChE19.3±1.820.0
DOI: https://doi.org/10.2478/aiht-2024-75-3822 | Journal eISSN: 1848-6312 (formerly 0004-1254) | Journal ISSN: 0004-1254
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Language: English, Croatian
Page range: 76 - 80
Submitted on: Jan 1, 2024
Accepted on: Mar 1, 2024
Published on: Mar 29, 2024
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Keywords:
AChE,
BChE,
cholinesterase,
inhibition,
herbicide,
neurotoxicity,
organophosphorus compounds,
pesticide
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2024 Dora Kolić, Vesna Pehar, Zrinka Kovarik, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 75 (2024): Issue 1 (March 2024)
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