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Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase Cover

Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase

Archives of Industrial Hygiene and Toxicology
Volume 75 (2024): Issue 1 (March 2024)
By: Dora Kolić,  Vesna Pehar and  Zrinka Kovarik  
Open Access
|Mar 2024

Figures & Tables

Figure 1

Chemical structure of glyphosate
Chemical structure of glyphosate

Figure 2

Glyphosate inhibition profiles for human AChE and BChE shown as the dissociation constant of the enzyme-inhibitor complex (Ki, upper panels) and IC50 values (lower panels) determined in the presence of substrate acetylthiocholine (ATCh) over a range of glyphosate concentrations (c). The same dataset was used to determine both kinetic profiles. Inhibition was evaluated from four experiments measured at 25 °C
Glyphosate inhibition profiles for human AChE and BChE shown as the dissociation constant of the enzyme-inhibitor complex (Ki, upper panels) and IC50 values (lower panels) determined in the presence of substrate acetylthiocholine (ATCh) over a range of glyphosate concentrations (c). The same dataset was used to determine both kinetic profiles. Inhibition was evaluated from four experiments measured at 25 °C

Dissociation constants (Ki) of glyphosate for human AChE and BChE and approximated IC50 values

EnzymeKi (mmol/L)Approx. IC50 (mmol/L)
AChE28.4±2.725.1
BChE19.3±1.820.0
DOI: https://doi.org/10.2478/aiht-2024-75-3822 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
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Language: English, Croatian, Slovenian
Page range: 76 - 80
Submitted on: Jan 1, 2024
|
Accepted on: Mar 1, 2024
|
Published on: Mar 29, 2024
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
AChE,
BChE,
cholinesterase,
inhibition,
herbicide,
neurotoxicity,
organophosphorus compounds,
pesticide
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2024 Dora Kolić, Vesna Pehar, Zrinka Kovarik, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution 4.0 License.

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