Have a personal or library account? Click to login
Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice Cover

Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice

Open Access
|Sep 2023

Figures & Tables

Figure 1

Kidney tissue MDA levels in mice by groups (A) and by sex and groups (B). C – control group; N – group receiving naringin (25 mg/kg); V – group receiving valproate (150 mg/kg), V+N – group receiving valproate (150 mg/kg) + naringin (25 mg/kg). Connecting lines – significant differences (p<0.05) between the groups. # significant differences (p<0.05) from control
Kidney tissue MDA levels in mice by groups (A) and by sex and groups (B). C – control group; N – group receiving naringin (25 mg/kg); V – group receiving valproate (150 mg/kg), V+N – group receiving valproate (150 mg/kg) + naringin (25 mg/kg). Connecting lines – significant differences (p<0.05) between the groups. # significant differences (p<0.05) from control

Figure 2

Kidney tissue catalase activity in mice by groups (A) and by sex and groups (B). C – control group; N – group receiving naringin (25 mg/kg); V – group receiving valproate (150 mg/kg), V+N – group receiving valproate (150 mg/kg) + naringin (25 mg/kg). Connecting lines – significant differences (p<0.05) between the groups. # significant differences (p<0.05) from control
Kidney tissue catalase activity in mice by groups (A) and by sex and groups (B). C – control group; N – group receiving naringin (25 mg/kg); V – group receiving valproate (150 mg/kg), V+N – group receiving valproate (150 mg/kg) + naringin (25 mg/kg). Connecting lines – significant differences (p<0.05) between the groups. # significant differences (p<0.05) from control

Figure 3

Kidney tissue superoxide dismutase activity levels in mice by groups (A) and by sex and groups (B). C – control group; N – group receiving naringin (25 mg/kg); V – group receiving valproate (150 mg/kg), V+N – group receiving valproate (150 mg/kg) + naringin (25 mg/kg). # significant differences (p<0.05) from control
Kidney tissue superoxide dismutase activity levels in mice by groups (A) and by sex and groups (B). C – control group; N – group receiving naringin (25 mg/kg); V – group receiving valproate (150 mg/kg), V+N – group receiving valproate (150 mg/kg) + naringin (25 mg/kg). # significant differences (p<0.05) from control

Figure 4

Kidney tissue glutathione levels in mice by groups (A) and by sex and groups (B). C – control group; N – group receiving naringin (25 mg/kg); V – group receiving valproate (150 mg/kg), V+N – group receiving valproate (150 mg/kg) + naringin (25 mg/kg). Connecting lines – significant differences (p<0.05) between the groups. # significant differences (p<0.05) from control
Kidney tissue glutathione levels in mice by groups (A) and by sex and groups (B). C – control group; N – group receiving naringin (25 mg/kg); V – group receiving valproate (150 mg/kg), V+N – group receiving valproate (150 mg/kg) + naringin (25 mg/kg). Connecting lines – significant differences (p<0.05) between the groups. # significant differences (p<0.05) from control

Serum sodium, potassium, and calcium levels in mice by groups and sex (medians and ranges)

GroupSexSodium (mmol/L)Potassium (mmol/L)Calcium (mmol/L)
CBoth153 (145–161)4.8 (4.3–4.9)1.75 (1.65–1.90)
V 152 (140–160)6.3 (4.6–8.5)*1.82 (1.80–1.92)
N 148 (147–165)5.5 (5.3–5.9)1.81 (1.70–1.90)
V+N 154 (141–161)5.1 (4.2–5.8)1.80 (1.60–1.90)
CMale155 (153–161)4.8 (4.3–4.9)1.84 (1.80–1.90)
Female153 (145–159)4.8 (4.4–4.8)1.75 (1.65–1.82)
VMale151 (140–158)7.2 (5.6–8.5)*1.82 (1.80–1.91)
Female152 (149–160)5.0 (4.6–7.0)#1.83 (1.80–1.92)
NMale158 (147–165)5.6 (5.3–5.9)1.81 (1.75–1.90)
Female145 (142–152)5.4 (5.3–5.6)1.82 (1.70–1.89)
V+NMale157 (152–161)5.1 (4.5–5.3)1.80 (1.62–1.90)
Female150 (141–159)5.2 (4.2–5.8)1.81 (1.60–1.90)
DOI: https://doi.org/10.2478/aiht-2023-74-3764 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
Language: English, Croatian, Slovenian
Page range: 218 - 223
Submitted on: Jul 1, 2023
Accepted on: Sep 1, 2023
Published on: Sep 30, 2023
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 David Jutrić, Domagoj Đikić, Almoš Boroš, Dyana Odeh, Romana Gračan, Anđelo Beletić, Irena Landeka Jurčević, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.