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Evaluation of the risk of occupational exposure to antineoplastic drugs in healthcare sector: part I – medical gloves Cover

Evaluation of the risk of occupational exposure to antineoplastic drugs in healthcare sector: part I – medical gloves

Archives of Industrial Hygiene and Toxicology
Volume 74 (2023): Issue 3 (September 2023)
By: Stefano Dugheri,  Donato Squillaci,  Giovanni Cappelli,  Valentina Saccomando,  Niccolò Fanfani,  Jacopo Ceccarelli,  Nicola Mucci and  Giulio Arcangeli  
Open Access
|Sep 2023

Figures & Tables

Figure 1

Nitrile glove sample collection (panels 1 & 2) and extraction procedure (panels 3 & 4)
Nitrile glove sample collection (panels 1 & 2) and extraction procedure (panels 3 & 4)

Figure 2

Calculation of the cumulative permeation and area under the curve at different time points. AUC – area under the curve; b1 – cumulative permeation (t1); b2 – cumulative permeation (t); BDT – breakthrough detection time; PR1 – permeation rate (t1); PR2 – permeation rate (t)
Calculation of the cumulative permeation and area under the curve at different time points. AUC – area under the curve; b1 – cumulative permeation (t1); b2 – cumulative permeation (t); BDT – breakthrough detection time; PR1 – permeation rate (t1); PR2 – permeation rate (t)

Figure 3

Prevalence of positive tests to antineoplastic drugs on collected nitrile gloves
Prevalence of positive tests to antineoplastic drugs on collected nitrile gloves

Figure 4

Calculated cumulative permeation and area under the curve (AUC) for carboplatin, cyclophosphamide, etoposide, 5-fluorouracil, iphosphamide, and carmustine after 120 min of exposure (assuming 0.05 mm glove thickness)
Calculated cumulative permeation and area under the curve (AUC) for carboplatin, cyclophosphamide, etoposide, 5-fluorouracil, iphosphamide, and carmustine after 120 min of exposure (assuming 0.05 mm glove thickness)

Figure 5

Comparison of carmustine permeation curves between nitrile gloves of different thickness
Comparison of carmustine permeation curves between nitrile gloves of different thickness

Cumulative AD contamination and total alert glove values (AGV-T) for administration and preparation units

Administration (pg/cm2)Preparation (pg/cm2)
Positive gloves (N)1544
Average cumulative contamination (pg/cm2)3691503
Highest cumulative contamination (pg/cm2)327933518
Cumulative 70th percentile (pg/cm2)<LOQ150
AGV-T (95th percentile) (pg/cm2)1233422

Glove contamination and calculated alert glove values (AGVs) in AD administration units expressed as pg/cm2

Administration unit
Positive gloves (N)Gloves with contamination >100 pg/cm2 (N)Average contamination (pg/cm2)Highest contamination (pg/cm2)90th percentile (pg/cm2)AGV Adm (95th percentile) (pg/cm2)LOQ (pg/cm2)
5-FU527843244<LOQ3.30.15
GEM314961385<LOQ<LOQ0.28
IRT0000<LOQ<LOQ0.06
CP0000<LOQ<LOQ0.03
DXR1078<LOQ<LOQ0.12
DC0000<LOQ<LOQ0.04
EPI0000<LOQ<LOQ0.11
ETP0000<LOQ<LOQ0.21
MT1055<LOQ<LOQ0.02
PTX0000<LOQ<LOQ0.19
DTX0000<LOQ<LOQ2.59
TMX0000<LOQ<LOQ0.08
TPT0000<LOQ<LOQ0.03
VNC0000<LOQ<LOQ0.16
VNB0000<LOQ<LOQ0.44
VNR101616<LOQ<LOQ0.06
FTM0000<LOQ<LOQ0.04
MITC1022<LOQ<LOQ0.02
IDC0000<LOQ<LOQ0.62
IP402352<LOQ<LOQ0.04
CTB0000<LOQ<LOQ0.06
MP0000<LOQ<LOQ0.18
BSF0000<LOQ<LOQ0.09
PMX0000<LOQ<LOQ0.09
RTX0000<LOQ<LOQ0.08
VND0000<LOQ<LOQ5.71
5-AZ0000<LOQ<LOQ0.70
CisPt0000<LOQ<LOQ29.58
CarboPt0000<LOQ<LOQ2.73
OxaliPt0000<LOQ<LOQ0.35

Glove contamination and calculated alert glove values (AGVs) in AD preparation units expressed as pg/cm2

Preparation unit
Positive gloves (N)Gloves with contamination >100 pg/cm2 (N)Average contamination (pg/cm2)Highest contamination (pg/cm2)90th percentile (pg/cm2)AGVPrep (95th percentile) (pg/cm2)LOQ (pg/cm2)
5-FU63366720729<LOQ13.60.15
GEM2310129212767163.61985.20.28
IRT103636<LOQ<LOQ0.06
CP123319293413.840.60.03
DXR103939<LOQ<LOQ0.12
DC2077<LOQ<LOQ0.04
EPI0000<LOQ<LOQ0.11
ETP203556<LOQ<LOQ0.21
MT105050<LOQ<LOQ0.02
PTX1251704873497.80.19
DTX0000<LOQ<LOQ2.59
TMX0000<LOQ<LOQ0.08
TPT0000<LOQ<LOQ0.03
VNC104646<LOQ<LOQ0.16
VNB0000<LOQ<LOQ0.44
VNR0000<LOQ<LOQ0.06
FTM0000<LOQ<LOQ0.04
MITC0000<LOQ<LOQ0.02
IDC0000<LOQ<LOQ0.62
IP5184395<LOQ0.60.04
CTB2126025190<LOQ<LOQ0.06
MP0000<LOQ<LOQ0.18
BSF101818<LOQ<LOQ0.09
PMX544211175<LOQ19.30.09
RTX0000<LOQ<LOQ0.08
VND0000<LOQ<LOQ5.71
5-AZ0000<LOQ<LOQ0.70
CisPt0000<LOQ<LOQ29.58
CarboPt610414<LOQ11.22.73
OxaliPt0000<LOQ<LOQ0.35
DOI: https://doi.org/10.2478/aiht-2023-74-3734 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254
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Language: English, Croatian, Slovenian
Page range: 187 - 197
Submitted on: Apr 1, 2023
Accepted on: Jul 1, 2023
Published on: Sep 30, 2023
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
alert glove values,
glove contamination,
glove permeation
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2023 Stefano Dugheri, Donato Squillaci, Giovanni Cappelli, Valentina Saccomando, Niccolò Fanfani, Jacopo Ceccarelli, Nicola Mucci, Giulio Arcangeli, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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