References
- Aydın B, Atlı Şekeroğlu Z, Şekeroğlu V. Effects of whey protein and conjugated linoleic acid on acrolein-induced cardiac oxidative stress, mitochondrial dysfunction and dyslipidemia in rats. Biomed Pharmacother 2018;107:901–7. doi: 10.1016/j.biopha.2018.08.081
- Aydın B, Atlı Şekeroğlu Z, Şekeroğlu V. Acrolein-induced oxidative stress and genotoxicity in rats: protective effects of whey protein and conjugated linoleic acid. Drug Chem Toxicol 2018;41:225–31. doi: 10.1080/01480545.2017.1354872
- Stevens JF, Maier CS. Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. Mol Nutr Food Res 2008;52:7–25. doi: 10.1002/mnfr.200700412
- Moghe A, Ghane S, Lamoreav B, Mohammad M, Barve S, McClain C, Joshi-Barve S. Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol Sci 2015;43:242–55. doi: 10.1093/toxsci/ kfu233
- Taghiabadi E, Imenshahidi M, Abnous K, Mosafa F, Sankian M, Memar B, Karimi G. Protective effect of silymarin against acrolein-induced cardiotoxicity in mice. Evid Based Complement Alternat Med 2012;2012:352091. doi: 10.1155/2012/352091
- Conklin DJ, Prough RA, Juvan P, Rezen T, Rozman D, Haberzettl P, Srivastava S, Bhatnagar A. Acrolein-induced dyslipidemia and acute-phase response are independent of HMG-CoA reductase. Mol Nutr Food Res 2011;55:1411–22. doi: 10.1002/mnfr.201100225
- Luo J, Shi R. Acrolein induces oxidative stress in brain mitochondria. Neurochem Int 2004;46:243–52. doi: 10.1016/j.neuint.2004.09.001
- Sun L, Luo C, Long J, Wei D, Liu J. Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion 2006;6:136–42. doi: 10.1016/j. mito.2006.04.003
- Kerasioti E, Veskoukis A, Virgiliou C, Theodoridis G, Taitzoglou I, Kouretas D. The strong antioxidant sheep/goat whey protein protects against mTOR overactivation in rats: a mode of action mimicking fasting. Antioxidants 2019;8(3):71. doi: 10.3390/antiox8030071
- Peng X, Kong B, Xia X, Liu Q. Reducing and radical scavenging activities of whey protein hydrolysates prepared with Alcalase. Int Dairy J 2010;20:360–5. doi: 10.1016/j.idairyj.2009.11.019
- Kim J, Paik HD, Yoon YC, Park E. Whey protein inhibits iron overload-induced oxidative stress in rats. J Nutr Sci Vitaminol 2013;59:198–205. doi: 10.3177/jnsv.59.198
- Liu O, Kong G, Han J, Sun C, Li P. Structure and antioxidant activity of whey protein isolate conjugated with glucose via the Maillard reaction under dry-heating conditions. Food Struct 2014;1:145–54. doi: 10.1016/j.foostr.2013.11.004
- Garg G, Singh AK, Singh S, Verma AK, Rizvi SI. Whey protein concentrate protects against age-dependent alteration in redox biomarkers. Biol Futur 2020;71:273–81. doi: 10.1007/s42977-020-00033-5
- Kume H, Okazaki K, Takahashi T, Yamaji T. Protective effect of an immune- modulating diet comprising whey peptides and fermented milk products on indomethacin- induced small-bowel disorders in rats. Clin Nutr 2014;33:1140–6. doi: 10.1016/j.clnu.2013.12.014
- Er R, Aydın B, Şekeroğlu V, Atlı Şekeroğlu Z. Protective effect of Argan oil on mitochondrial function and oxidative stress against acrylamide-induced liver and kidney injury in rats. Biomarkers 2020;25:458–67. doi: 10.1080/1354750X.2020.1797877
- National Research Council. Guide for the Care and Use of Laboratory Animals. 8th ed. Washington (DC): The National Academies Press; 2011.
- Johnson D, Lardy H. Isolation of liver or kidney mitochondria. Methods Enzymol 1967;10:94–6. doi: 10.1016/0076-6879(67)10018-9
- Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265–75. doi: 10.1016/S0021-9258(19)52451-6
- Beauchamp C, Fridavich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 1971;44:276–87. doi: 10.1016/0003-2697(71)90370-8
- Flohe L, Günzler WA. Assays of glutathione peroxidase. Methods Enzymol 1984;105:114–21. doi: 10.1016/s0076-6879(84)05015-1
- Moron MS, Depierre JW, Mannervik B. Levels of glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979;582:67–78. doi: 10.1016/0304-4165(79)90289-7
- Esterbauer H, Chessman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990;186:407–21. doi: 10.1016/0076-6879(90)86134-h
- Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadtman ER. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990;186:464–78. doi: 10.1016/0076-6879(90)86141-h
- Janssen AJ, Trijbels FJ, Sengers RC, Smeitink JA, van den Heuvel LP, Wintjes LT, Stoltenborg-Hogenkamp BJ, Rodenburg RJ. Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts. Clin Chem 2007;53:729–34. doi: 10.1373/clinchem.2006.078873
- Trounce IA, Kim YL, Jun AS, Wallace DC. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines. Methods Enzymol 1996;264:484-509. doi: 10.1016/s0076-6879(96)64044-0
- Fatania H, al-Nassar KE, Sidhan V. Purification and partial characterisation of NADP+-linked isocitrate dehydrogenase from rat liver cytosol. FEBS Lett 1993;320:57–60. doi: 10.1016/0014-5793(93)81657-l
- Lucas DT, Aryal P, Szweda LI, Koch WJ, Leinwand LA. Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 2003;284:H575–83. doi: 10.1152/ajpheart.00619.2002
- Gelpi JL, Dordal A, Montserrat J, Mazo A, Cortés A. Kinetic studies of the regulation of mitochondrial malate dehydrogenase by citrate. Biochem J 1992;283(Pt 1):289–97. doi: 10.1042/bj2830289
- Degli Esposti D, Hamelin J, Bosselut N, Saffroy R, Sebagh M, Pommier A, Martel C, Lemoine A. Mitochondrial roles and cytoprotection in chronic liver injury. Biochem Res Int 2012;2012:387626: doi: 10.1155/2012/387626
- Morio B, Panthu B, Bassot A, Rieusset J. Role of mitochondria in liver metabolic health and diseases. Cell Calcium 2021;94:102336. doi: 10.1016/j.ceca.2020.102336
- Kaminskas LM, Pyke SM, Burcham PC. Differences in lysine adduction by acrolein and methyl vinyl ketone: implications for cytotoxicity in cultured hepatocytes. Chem Res Toxicol 2005;18:1627–33. doi: 10.1021/tx0502387
- Mohammad MK, Avila D, Zhang J, Barve S, Arteel G, McClain C, Joshi-Barve S. Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress. Toxicol Appl Pharmacol 2012;265:73–82. doi: 10.1016/j. taap.2012.09.021
- Shafie B, Pourahmad J, Rezaei M. N-acetylcysteine is more effective than ellagic acid in preventing acrolein induced dysfunction in mitochondria isolated from rat liver. J Food Biochem 2021;45(7):e13775. doi: 10.1111/jfbc.13775
- Mantena SK, King AL, Andringa KK, Ecclestdon HB, Bailey SM. Mitochondrial dysfunction and oxidative ioene in the pathogenensis of alcohol- and obesity-indiced fatty liver diseases. Free Radic Biol Med 2008;44:1259–72. doi: 10.1016/j.freeradbiomed.2007.12.029
- Şekeroğlu V, Aydın B, Atlı Şekeroğlu Z, Özdener Kömpe Y. Hepatoprotective effects of capsaicin and alpha-tocopherol on mitochondrial function in mice fed a high-fat diet. Biomed Pharmacother 2018;98:821–5. doi: 10.1016/j.biopha.2018.01.026
- Shertzer HG, Krishan M, Genter MB. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neurosci Lett 2013;548:159–64. doi: 10.1016/j. neulet.2013.05.061
- Jin MM, Zhang L, Yu HX, Meng J, Sun Z, Lu RR. Protective effect of whey protein hydrolysates on H2O2-induced PC12 cells oxidative stress via a mitochondria-mediated pathway. Food Chem 2013;141:847–52. doi: 10.1016/j.foodchem.2013.03.076
- Tong X, Li W, Xu JY, Han S, Qin LQ. Effects of whey protein and leucine supplementation on insulin resistance in non-obese insulin-resistant model rats. Nutrition 2014;30:1076–80. doi: 10.1016/j. nut.2014.01.013
- Mansour DF, Nada SA, El-Denshary ES, Omara EA, Asaad GF, Abdel-Rahman RF. Milk whey proteins modulate endotoxemia-induced hepatotoxicity in rats. Int J Pharm Pharm Sci 2015;7:65–71.
- Park E, Paik HD, Lee SM. Combined effects of whey protein hydrolysates and probiotics on oxidative stress induced by an iron-overloaded diet in rats. Int J Food Sci Nutr 2018;69:298–307. doi: 10.1080/09637486.2017.1354977
- Chranthi M, Rao GM, Pandey R, Jalajakshi, Marathe A. Ameliorating effect of whey preparation on Na+ -K+ -ATPase and oxidative stress in chemotherapy induced rat model for brain toxicity. Biomedicine 2019;39:405–9. doi: 10.51248/.v39i3.156
- Geng C, Xu H, Zhang Y, Gao Y, Li M, Liu X, Gao M, Wang X, Liu X, Fang F, Chang Y. Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1. Sci China Life Sci 2017;60:1234–41. doi: 10.1007/s11427-016-9027-6
- Athira S, Mann B, Sharma R, Kumar R. Ameliorative potential of whey protein hydrolysate against paracetamol-induced oxidative stress. J Dairy Sci 2013;96:1431–7. doi: 10.3168/jds.2012-6080
- Żebrowska-Gamdzyk M, Maciejczyk M, Zalewska A, Guzińska-Ustymowicz K, Tokajuk A, Car H. Whey protein concentrate WPC-80 intensifies glycoconjugate catabolism and induces oxidative stress in the liver of rats. Nutrients 2018;10(9):1178. doi: 10.3390/nu10091178
- Derosa G, D’Angelo A, Maffioli P. Change of some oxidative stress parameters after supplementation with whey protein isolate in patients with type 2 diabetes. Nutrition 2020;73:110700. doi: 10.1016/j. nut.2019.110700
- Mohandas G, Rao SV, Muralidhara, Rajini PS. Whey protein isolate enrichment attenuates manganese-induced oxidative stress and neurotoxicity in Drosophila melanogaster: Relevance to Parkinson’s disease. Biomed Pharmacother 2017;95:1596–606. doi: 10.1016/j. biopha.2017.09.099
- Gad AS, Khadrawy YA, El-Nekeety AA, Mohamed SR, Hassan NS, Abdel-Wahhab MA. Antioxidant activity and hepatoprotective effects of whey protein and Spirulina in rats. Nutrition 2011;27:582–9. doi: 10.1016/j.nut.2010.04.002
- Lee JH, Yang ES, Park J-W. Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury. J Biol Chem 2003;278:51360–71. doi: 10.1074/jbc.M302332200
- Nemoto S, Fergusson MM, Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 2005;280(16):16456–60. doi: 10.1074/jbc.M501485200
- Han SJ, Choi HS, Kim JI, Park JW, Park KM. IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increased mitochondrial oxidative injury. Redox Biol 2018;14:142–53. doi: 10.1016/j.redox.2017.09.003
- Tretter L, Adam-Vizi V. Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress. Philos Trans R Soc Lond B Biol Sci 2005;360:2335–45. doi: 10.1098/rstb.2005.1764