References
- Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, Toppari J, Zoeller RT. EDC-2: The endocrine society’s second scientific statement on endocrine-disrupting chemicals. Endocr Rev 2015;36(6):E1 –150. doi: 10.1210/er.2015-1010
- Street ME, Angelini S, Bernasconi S, Burgio E, Cassio A, Catellani C, Cirillo F, Deodati A, Fabbriz E, Fanos V, Gargano G, Grossi E, Lughetti L, Lazzeroni P, Mantovani A, Migliore L, Palanza P, Panzica G, Papini AM, Parmigiani S, Predieri B, Sartori C, Tridenti G, Amarri S. Current knowledge on endocrine disrupting chemicals (EDCs) from animal biology to humans, from pregnancy to adulthood: Highlights from a National Italian Meeting. Int J Mol Sci 2018;19(6):1647. doi: 10.3390/ijms19061647
- Ortiz A, Sansinenea E. Di-2-ethylhexylphthalate may be a natural product, rather than a pollutant. J Chem 2018;ID6040814:1 –7. doi: 10.1155/2018/6040814
- Choi K, Joo H, Campbell JL, Jr, Clewell RA, Andersen ME, Clewell HJ 3rd. In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat. Toxicol In Vitro 2012;26:315 –22. doi: 10.1016/j.tiv.2011.12.002
- United States Environmental Protection Agency. Priority pollutant list [displayed 17/November/2022]. Available at https://www.epa.gov/sites/default/files/2015-09/documents/priority-pollutant-list-epa.pdf
- Directive 2008/105/EC of the European Parliament and of the Council of 16 December 2008 on environmental quality standards in the field of water policy, amending and subsequently repealing Council Directives 82/176/EEC, 83/513/EEC, 84/156/EEC, 84/491/EEC, 86/280/EEC and amending Directive 2000/60/EC of the European Parliament and of the Council [displayed 17/November/2022]. Available at: https://eur-lex.europa.eu/legal-content/EN/TXT/HTML/?uri=CELEX :32008L0105&from=EN
- Kolena B, Petrovicova I, Pilka T, Pucherova Z, Munk M, Matula B, Vankova V, Petlus P, Jenisova Z, Rozova Z, Wimmerova S, Trnovec T. Phthalate exposure and health-related outcomes in specific types of work environment. Int J Environ Res Public Health 2014;11:5628 –39. doi: 10.3390/ijerph110605628
- Doan K, Bronaugh LR, Yourick JJ. In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. Food Chem Toxicol 2010;48:18 –23. doi: 10.1016/j.fct.2009.09.002
- US EPA. Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) Final Report [displayed 31 October 2022]. Available at https://www.epa.gov/endocrine-disruption/endocrine-disruptor-screening-and-testing-advisory-committee-edstac-final
- Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Duk-Hee Jr T, Lee, Shioda Soto, vom Saal FS, Welshons WV, Zoeller RT, Myers JP. Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses. Endocr Rev 2012;33:378 –455. doi: 10.1210/er.2011-1050
- Karabulut G, Barlas N. Genotoxic, histologic, immunohistochemical, morphometric and hormonal effects of di-(2-ethylhexyl)-phthalate (DEHP) on reproductive systems in pre-pubertal male rats. Toxicol Res 2018;7:859 –73. doi: 10.1039/c8tx00045j
- European Union Risk Assessment Report: Dibutyl Phthalate. CAS No: 84-74-2. EINECS No: 201-557-4 [displayed 2 November 2022]. Available at https://echa.europa.eu/documents/10162/04f79b21-0b6d-4e67-91b9-0a70d4ea7500
- Qi W, Zhou L, Zhao T, Ding S, Xu Q, Han X, Zhao Y, Song X, Zhao T, Zhang X, Ye L. Effect of the tyk-2/stat-3 pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate. Mol Cell Endocrinol 2019;484:52 –8. doi: 10.1016/j.mce.2019.01.012
- Rajagopal G, Bhaskaran RS, Karundevi B. Developmental exposure to DEHP alters hepatic glucose uptake and transcriptional regulation of GLUT2 in rat male offspring. Toxicology 2019;413:56 –64. doi: 10.1016/j.tox.2018.12.004
- Zhang W, Shen XY, Zhang WW, Chen H, Xu WP, Wei W. Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ. Toxicol Appl Pharmacol 2017;316:17 –26. doi: 10.1016/j.taap.2016.12.010
- Zhang W, Shen XY, Zhang WW, Chen H, Xu WP, Wei W. The effects of di 2-ethyl hexyl phthalate (DEHP) on cellular lipid accumulation in HepG2 cells and its potential mechanisms in the molecular level. To x i co l Me c h Me t hod s 2 0 1 7 ; 2 7 : 2 4 5 – 5 2 . do i : 10.1080/15376516.2016.1273427
- Rusyn I, Corton JC. Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Mutat Res 2012;750:141 –58. doi: 10.1016/j.mrrev.2011.12.004
- Kwack SJ, Han EY, Park JS, Bae JY, Ahn IY, Lim SK, Kim DH, Jang DE, Choi L, Lim HJ, Kim TH, Patra N, Park KL, Kim HS, Lee BM. Comparison of the short term toxicity of phthalate diesters and monoesters in sprague-dawley male rats. Toxicol Res 2010;26:75 –82. doi: 10.5487/TR.2010.26.1.075
- Ferguson KK, Loch-Caruso R, Meeker JD. Urinary phthalate metabolites in relation to biomarkers of inflammation and oxidative stress: NHANES 2011. Environ Res 2011;111:718 –26. doi: 10.1016/j. envres.2011.02.002
- Ballard HS. The hematological complications of alcoholism. Alcohol Health Res World 1997;21:42 –52. PMCID: PMC6826798
- Metz J. Appropriate use of tests for folate and vitamin B12 deficiency. Aust Prescr 1999;22:16 –8. doi: 10.18773/austprescr.1999.010
- Freeman VS. Glucose and hemoglobin A1c. Lab Med 2014;45:e21 –4. doi: 10.1309/LMNSU432YJWCWZKX
- Sicińska P. Di-n-butyl phthalate, butylbenzyl phthalate and their metabolites induce haemolysis and eryptosis in human erythrocytes. Chem 2018;203:44 –53. doi: 10.1016/j.chemosphere.2018.03.161
- Stamateris RE, Sharma RB, Hollern DA, Alonso LC. Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression. Am J Physiol Endocrinol Metabol 2013;305:E149 –59. doi: 10.1152/ ajpendo.00040.2013
- Duntas LH. Chemical contamination and the thyroid. Endocrine 2015;48:53 –64. doi: 10.1007/s12020-014-0442-4
- Rajesh P, Sathish S, Srinivasan C, Selvaraj J, Balasubramanian K. Phthalate is associated with insulin resistance in adipose tissue of male rat: role of antioxidant vitamins. J Cell Biochem 2013;114:558 –69. doi: 10.1002/jcb.24399
- Deng T, Zhang Y, Wu Y, Ma P, Duan J, Qin W, Yang X, Chen M. Dibutyl phthalate exposure aggravates type 2diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway. Toxicol Lett 2018;290:1 –9. doi: 10.1016/j.toxlet.2018.03.004
- Wang J, Li J, Zahid KR, Wang K, Qian Y, Ma P, Ding S, Yang X, Wang X. Adverse effect of DEHP exposure on the serum insulin level of Balb/c mice. Mol Cell Toxicol 2016;12:83 –91. doi: 10.1007/s13273-016-0011-4
- The Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus; Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E, Ito C, Inagaki N, Iwamoto Y, Kasuga M, Hanafusa T, Haneda M, Ueki K. Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Invest 2010;1:212 –28. doi: 10.1111/j.2040-1124.2010.00074.x
- Hanafusa T, Imagawa A. Fulminant type 1 diabetes: A novel clinical entity requiring special attention by all medical practitioners. Nat Rev Endocrinol 2007;3:36 –45. doi: 10.1038/ncpendmet0351
- Lampasona V, Liberati D. Islet autoantibodies. Curr Diab Rep 2016;16:53. doi: 10.1007/s11892-016-0738-2
- Hayashi Y, Ito Y, Yamagishi N, Yanagiba Y, Tamada H, Wang D, Nakajima T. Hepatic peroxisome proliferator-activated receptor α may have an important role in the toxic effects of di (2-ethylhexyl) phthalate on offspring of mice. Toxicology 2011;289:1 –10. doi: 10.1016/j. tox.2011.02.007
- Nakashima R, Hayashi Y, Md K, Jia X, Wang D, Naito H, Nakajima T. Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. Toxicology 2013;309:52 –60. doi: 10.1016/j. tox.2013.04.010
- Yang G, Gao X, Jiang L. 6-gingerol prevents mehp-induced DNA damage in human umbilical vein endothelia cells. Hum Exp Toxicol 2017;36:1177 –85. doi: 10.1177/0960327116681650
- Giri B, Dey S, Das T, Sarkar M, Banerjee J, Dash SK. Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity. Biomed Pharmacother 2018;107:306 –28. doi: 10.1016/j. biopha.2018.07.157
- Sone H, Kagawa Y. Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice. Diabetologia 2005;48:58 –67. doi: 10.1007/s00125-004-1605-2
- Bastos Sales L, van Esterik JCJ, Hodemaekers HM, Lamoree MH, Hamers T, van der Ven LTM, Legler J. Analysis of lipid metabolism, immune function, and neurobehavior in adult C57BL/6JxFVB mice after developmental exposure to di (2-ethylhexyl) phthalate. Front Endocrinol (Lausanne) 2018;9:684. doi: 10.3389/fendo.2018.00684
- Shulman GI. Celular mechanism of insulin resistance. J Clin Invest 2000;6:171 –6. doi: 10.1172/JCI10583
- Choi SE, Jung R, Lee YL, Lee SJ, Lee JH, Kim Y, Jun HS, Lee KW, Park CB, Kang Y. Stimulation of lipogenesis as well as fatty acidoxidation protects againts palmitate-induced INS-1 beta cell death. Endocrinology 2011;152:816 –27. doi: 10.1210/en.2010-0924
- Cantley J, Ashcroft FM. Q&A: insulin secretion and type 2 diabetes: why do β-cells fail? BMC Biol 2015;13:33. doi: 10.1186/s12915-015-0140-6
- Khasanah Y, Ratnayani Ariani D, Angwar M, Nuraeni T. In vivo study on albumin and total protein in white rat (Rattus Norvegicus) after feeding of enteral formula from tempe and local food. Procedia Food Sci 2015;3:274 –9. doi: 10.1016/j.profoo.2015.01.030
- EPA. Toxicological Review of Urea [displayed 2 November 2022]. Available at https://iris.epa.gov/static/pdfs/1022tr.pdf
- Tanaka A, Adachi T, Takahashi T, Yamaha T. Biochemical studies on phthalic esters I. Elimination, distribution and metabolism of di-(2-ethylhexyl) phthalate in rats. Toxicology 1975;4:253 –64. doi: 10.1016/0300-483x(75)90105-5
- Rhodes C, Orton TC, Pratt IS, Batten PL, Bratt H, Jackson SJ, Elcombe CR. Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl) phthalate (DEHP) in rats and marmosets: extrapolation of effects in rodents to man. Environ Health Perspect 1986;65:299 –307. doi: 10.1289/ehp.8665299
- Erkekoglu P, Kocer-Gumusel B. Genotoxicity of phthalates. Toxicol Mech Methods 2014;24:616 –26. doi: 10.3109/15376516.2014.960987
- Ferguson KK, Cantonwine DE, Rivera-Gonzalez LO, Loch-Caruso R, Mukherjee B, Anzalota Del Toro LV, Jimenez-Velez B, Calafat AM, Ye X, Alshawabkeh AN, Cordero JF, Meeker JD. Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol 2014;48:7018 –25. doi: 10.1021/es502076j