Genotoxicity of aluminium oxide, iron oxide, and copper nanoparticles in mouse bone marrow cells

Figures & Tables

Group	Dose (mg/kg)	No. of analysed metaphases	Chromosomal aberrations				TA/500 cells	CA/cell Mean ± SD
Group	Dose (mg/kg)	No. of analysed metaphases	CtB	ChB	CtG	ChG	TA/500 cells	CA/cell Mean ± SD
Fe₂O₃ nanoparticles
NC	0	500	18	13	14	15	60	0.120±0.026
PC	2	500	106	35	104	60	305	0.610±0.081*
1	75	500	21	10	35	15	89	0.178±0.057
2	150	500	20	12	38	10	86	0.172±0.023
3	300	500	27	09	40	16	92	0.184±0.029
Al₂O₃ nanoparticles
NC	0	500	14	16	11	17	58	0.116±0.019
PC	2	500	102	41	115	53	311	0.622±0.147*
1	75	500	20	13	38	12	83	0.166±0.081
2	150	500	15	10	43	10	79	0.158±0.046
3	300	500	19	14	40	11	89	0.168±0.039
Cu nanoparticles
NC	0	500	15	12	18	16	61	0.12 ±0.037
PC	2	500	98	35	110	61	304	0.608±0.081*
1	5	500	20	13	22	15	70	0.140±0.054
2	10	500	19	14	20	16	69	0.138±0.048
3	15	500	50	26	68	41	185	0.370±0.076*

Group	Dose (mg/kg)	No. of analysed metaphases	No. of mitotic cells	Mitotic index (%)
Fe₂O₃ nanoparticles
NC	0	5000	409	8.180±0.540
PC	2	5000	61	1.220±0.259*
1	75	5000	399	7.980±0.370
2	150	5000	395	7.900±0.709
3	300	5000	401	8.080±1.180
Al₂O₃ nanoparticles
NC	0	5000	417	8.340±0.351
PC	2	5000	58	1.160±0.288*
1	75	5000	403	8.060±0.517
2	150	5000	409	8.180±0.687
3	300	5000	399	7.980±0.991
Cu nanoparticles
NC	0	5000	411	8.220±0.277
PC	2	5000	54	1.080±0.238*
1	5	5000	406	8.120±0.868
2	10	5000	399	7.980±0.673
3	15	5000	309	6.180±0.802*