References
- Pan Y, Zhao YL, Zhang J, Li WY, Wang YZ. Phytochemistry and pharmacological activities of the genus Gentiana (Gentianaceae). Chem Biodivers 2016;13:107–50. doi: 10.1002/cbdv.201500333
- Mirzaee F, Hosseini A, Jouybari HB, Davoodi A, Azadbakht M. Medicinal, biological and phytochemical properties of Gentiana species. J Tradit Complement Med 2017;7:400–8. doi: 10.1016/j.jtcme.2016.12.013
- Olennikov DN, Kashchenko NI, Chirikova NK, Tankhaeva LM. Iridoids and flavonoids of four Siberian gentians: chemical profile and gastric stimulatory effect. Molecules 2015;20(10):19172–88. doi: 10.3390/molecules201019172
- Azman NAM, Segovia F, Martínez-Farré X, Gil E, Almajano MP. Screening of antioxidant activity of Gentian lutea root and its application in oil-in-water emulsions. Antioxidants (Basel) 2014;3:455–71. doi: 10.3390/antiox3020455
- Savikin K, Menković N, Zdunić G, Stević T, Radanović D, Janković T. Antimicrobial activity of Gentiana lutea L. extracts. Z Naturforsch C J Biosci 2009;64:339–42. doi: 10.1515/znc-2009-5-606
- Seiwerth J, Tasiopoulou G, Hoffmann J, Wölfle U, Schwabe K, Quirin KW, Schempp CM. Anti-inflammatory effect of a novel topical herbal composition (VEL-091604) consisting of gentian root, licorice root and willow bark extract. Planta Med 2019;85:608–14. doi: 10.1055/a-0835-6806
- Menkovic N, Juranic Z, Stanojkovic T, Raonic-Stevanovic T, Savikin K, Zdunić G, Borojevic N. Radioprotective activity of Gentiana lutea extract and mangiferin. Phytother Res 2010;24:1693–6. doi: 10.1002/ptr.3225
- Joksić G, Filipović Tričković J, Joksić I. Potential of Gentiana lutea for the treatment of obesity-associated diseases. Curr Pharm Des 2019;25:2071–6. doi: 10.2174/1381612825666 190708215743
- Park E, Lee CG, Kim J, Yeo S, Kim JA, Choi CW, Jeong SY. Antiobesity effects of Gentiana lutea extract on 3T3-L1 preadipocytes and a high-fat diet- induced mouse model. Molecules 2020;25(10):2453. doi: 10.3390/molecules25102453
- Kesavan R, Chandel S, Upadhyay S, Bendre R, Ganugula R, Potunuru UR, Giri h, Sahu G, Kumar PU, Reddy GB, Joksic G, Bera AK, Dixit M. Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. Nutr Metab Cardiovasc Dis 2016;26:293–301. doi: 10.1016/j.numecd.2015.12.016
- Kesavan R, Potunuru UR, Nastasijević B, Avaneesh T, Joksić G, Dixit M. Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts. PLoS One 2013;8(4):e61393. doi: 10.1371/journal.pone.0061393
- Patenković A, Stamenković-Radak M, Nikolić D, Marković T, Anđelković M. Synergistic effect of Gentiana lutea L. on methyl methanesulfonate genotoxicity in the Drosophila wing spot test. J Ethnopharmacol 2013;146:632–6. doi: 10.1016/j.jep.2013.01.027
- Wani BA, Ramamoorthy D, Rather MA, Arumugam N, Qazi AK, Majeed R, Hamid A, Ganie SA, Ganai BA, Anand R, Gupta AP. Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (ΔΨm) by Gentiana kurroo root extract and LCESI-MS analysis of its principal constituents. Phytomedicine 2013;20:723–33. doi: 10.1016/j.phymed.2013.01.011
- Balijagić J, Janković T, Zdunić G, Bosković J, Savikin K, Godevac D, Stanojković T, Jovancević M, Menković N. Chemical profile, radical scavenging and cytotoxic activity of yellow gentian leaves Genitaneae luteaefolium grown in northern regions of Montenegro. Nat Prod Commun 2012;7:1487–90. PMID: 23285813
- Rodrigues C, Karmali A, Machado J. The extracts of Gentiana lutea with potential cytotoxic effects on human carcinoma cell lines: A preliminary study. Eur J Integr Med 2019;27:34–8. doi: 10.1016/j.eujim.2019.02.008
- Ladeira C. Mycotoxins: genotoxicity studies and methodologies. In: Viegas C, Pinheiro AC, Sabino R, Viegas S, Brandão J, Veríssimo C, editors. Environmental mycology in public health. Amsterdam: Academic Press; 2016. p. 343–61. doi: 10.1016/B978-0-12-411471-5.00020-X
- Strober W. Trypan blue exclusion test of cell viability. Curr Protoc Immunol 2015;111:A3.B.1-A3.B.3. doi: 10.1002/0471142735.ima03bs111
- Organisation for Economic Cooperation and Development (OECD). Guidelines for the Testing of Chemicals No 473: In Vitro Mammalian Chromosomal Aberration Test. Paris:OECD; 2016. doi: 10.1787/9789264264649-en
- Filipović J, Joksić G, Vujić D, Joksić I, Mrasek K, Weise A, Liehr, T. First molecular-cytogenetic characterization of Fanconi anemia fragile sites in primary lymphocytes of FAD2 patients in different stages of the disease. Mol Cytogenet 2016;9:70. doi: 10.1186/s13039-016-0280-6
- Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184–91. doi: 10.1016/0014-4827(88)90265-0
- Alamdari DH, Paletas K, Pegiou T, Sarigianni M, Befani C, Koliakos G. A novel assay for the evaluation of the prooxidant-antioxidant balance, before and after antioxidant vitamin administration in type II diabetes patients. Clin Biochem 2007;40:248–54. doi: 10.1016/j. clinbiochem.2006.10.017
- Esterbauer h, Schaur RJ, Zollner h. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991;11:81–128. doi: 10.1016/0891-5849(91)90192-6
- Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Anal Biochem 2017;524:13–30. doi: 10.1016/j.ab.2016.10.021
- Valenta Sobot A, Savic J, Filipovic Trickovic J, Drakulic D, Joksic G. Toxicity assessment of Gentiana lutea L. root extract and its monoterpene compounds. Indian J Exp Biol 2020;58:609–16. URI: http://nopr.niscair.res.in/handle/123456789/55047
- Mubashir K, Ganai BA, Ghazanfar K, Akbar S, Rah B, Tantry M, Masood A. Anti-inflammatory and immuno-modulatory studies on LC-MS characterised methanol extract of Gentiana kurroo Royle. BMC Complement Altern Med 2017;17:78. doi: 10.1186/s12906-017-1593-7
- Hudecová A, Hašplová K, Miadoková E, Magdolenová Z, Rinna A, Collins AR, Gálová E, Vaculčíková D, Gregáň F, Dušinská M. Gentiana asclepiadea protects human cells against oxidation DNA lesions. Cell Biochem Funct 2012;30:101–7. doi: 10.1002/cbf.1822
- Alarifi S, Ali D, Alkahtani S, Verma A, Ahamed M, Ahmed M, Alhadlaq HA. Induction of oxidative stress, DNA damage, and apoptosis in a malignant human skin melanoma cell line after exposure to zinc oxide nanoparticles. Int J Nanomedicine 2013;8:983–93. doi: 10.2147/IJN.S42028
- Van Houten B, Santa-Gonzalez GA, Camargo M. DNA repair after oxidative stress: Current challenges. Curr Opin Toxicol 2018;7:9–16. doi: 10.1016/j.cotox.2017.10.009
- Kusar A, Zupancic A, Sentjurc M, Baricevic D. Free radical scavenging activities of yellow gentian Gentiana lutea L.) measured by electron spin resonance. Hum Exp Toxicol 2006;25:599–604. doi: 10.1177/096032706072467
- Nastasijević B, Lazarević-Pašti T, Dimitrijević-Branković S, Pašti I, Vujačić A, Joksić G, Vasić V. Inhibition of myeloperoxidase and antioxidative activity of Gentiana lutea extracts. J Pharm Biomed Anal 2012;66:191–6. doi: 10.1016/j.jpba.2012.03.052
- Halliwell B, Aeschbach R, Löliger J, Aruoma OI. The characterization of antioxidants. Food Chem Toxicol 1995;33:601–17. doi: 10.1016/0278-6915(95)00024-v
- Mihailović V, Katanić J, Mišić D, Stanković V, Mihailović M, Uskoković A, Arambašić J, Solujić S, Mladenović M, Stanković N. Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats. Food Funct 2014;5:1795–803. doi: 10.1039/c4fo00088a
- Mihailović V, Mihailović M, Uskoković A, Arambašić J, Mišić D, Stanković V, Katanić J, Mladenović M, Solujić S, Matić S. Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. Food Chem Toxicol 2013;52:83–90. doi: 10.1016/j. fct.2012.10.034
- Petrovic S, Leskovac A, Joksic G. Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro. Curr Sci (Bangalore) 2008;95:1035–41.
- Ježovičová M, Koňariková K, Ďuračková Z, Keresteš J, Králik G, Žitňanová I. Protective effects of black tea extract against oxidative DNA damage in human lymphocytes. Mol Med Rep 2016;13:1839–44. doi: 10.3892/mmr.2015.4747
- Elbling L, Weiss R-M, Teufelhofer O, Uhl M, Knasmueller S, Schulte-Hermann R, Berger W, Micksche M. Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities. FASEB J 2005;19:807–9. doi: 10.1096/fj.04-2915fje
- Hayashi M, Umezu K. Homologous recombination is required for recovery from oxidative DNA damage. Genes Genet Syst 2017;92:73–80. doi: 10.1266/ggs.16-00066
- Wang C, Yang J, Lu D, Fan Y, Zhao M, Li Z. Oxidative stress-related DNA damage and homologous recombination repairing induced by N,N-dimethylformamide. J Appl Toxicol 2016;36:936–45. doi: 10.1002/jat.3226