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The canonical FGF-FGFR signaling system at the molecular level

Postępy Higieny i Medycyny Doświadczalnej
Volume 75 (2021): Issue 1 (January 2021)
By:
Open Access
|Jan 2022

Figures & Tables

Figure 1.

The FGF family. The mammalian FGFs can be divided into three subgroups based on their way of action. The intracrine FGFs are not secreted and remain inside the signaling cell. The paracrine and endocrine FGFs are secreted and bind to receiver cells but the endocrine FGFs mainly play roles in an endocrine manner via the blood circulation system.
The FGF family. The mammalian FGFs can be divided into three subgroups based on their way of action. The intracrine FGFs are not secreted and remain inside the signaling cell. The paracrine and endocrine FGFs are secreted and bind to receiver cells but the endocrine FGFs mainly play roles in an endocrine manner via the blood circulation system.

Figure 2.

A schematic presentation of the structure and the activation of FGFRs. (A) FGFRs consist of two or three extracellular immunoglobulin (Ig)-like domains (IgI-IgIII), a transmembrane domain and an intracellular split tyrosine kinase domain (TKI and TKII). An acid box is located between IgI and IgII. The IgII contains also a heparin binding domain. IgIII in FGFR1-3 is alternatively spliced to IgIIIb or IgIIIc variants. (B) Activation of FGFRs. FGF-FGFR interaction in the presence of heparan sulfate triggers receptor dimerization and activation of the tyrosine kinase domain of the receptors.
A schematic presentation of the structure and the activation of FGFRs. (A) FGFRs consist of two or three extracellular immunoglobulin (Ig)-like domains (IgI-IgIII), a transmembrane domain and an intracellular split tyrosine kinase domain (TKI and TKII). An acid box is located between IgI and IgII. The IgII contains also a heparin binding domain. IgIII in FGFR1-3 is alternatively spliced to IgIIIb or IgIIIc variants. (B) Activation of FGFRs. FGF-FGFR interaction in the presence of heparan sulfate triggers receptor dimerization and activation of the tyrosine kinase domain of the receptors.
DOI: https://doi.org/10.2478/ahem-2021-0024 | Journal eISSN: 1732-2693
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Language: English
Page range: 711 - 719
Submitted on: Oct 16, 2020
Accepted on: Feb 24, 2021
Published on: Jan 17, 2022
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
Fibroblast growth factors,
fibroblast growth factor receptors,
cellular signaling,
tissue homeostasis
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Medicine,
Basic medical science,
Immunology

© 2022 Patrycja Szybowska, Ellen Margrethe Haugsten, Antoni Wiedlocha, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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