Effect of Bacterial Biofilms on Topical Antimicrobial Therapy

MODEL A	*P. aeruginosa 1*	*P. aeruginosa 2*	*S. aureus*	*E. coli*	*E. faecalis*	*A. baumannii*
AA1%	+++	+++	+	0	+	+++
FUR	0	0	+++	0	+++	0
Aqvitox	+++	0	0	0	0	+++
Octenisept	+++	+++	+++	+++	+++	+++
SS1%	+++	+++	+++	+++	+++	+++
AA1%+SS1%	+++	+++	+++	+++	+++	+++
Ialugen plus	+++	+++	+++	+++	+++	+++
Acticoat	+++	+++	+++	+++	+++	+++
Aquacel Ag	+++	+++	+++	0	0	+
Actilite	0	0	+++	0	0	+++
Betadine	+++	+++	+++	+++	+++	+++
MODEL B	*P. aeruginosa 1*	*P. aeruginosa 2*	*S. aureus*	*E. coli*	*E. faecalis*	*A. baumannii*
AA1%	+++	+++	+	0	+	+++
FUR0,2%	0	0	+++	0	+++	0
Aqvitox-D	0	0	0	0	0	0
Octenisept	+++	+++	+++	+++	+++	+++
SS1%	+++	+++	+++	+++	+++	0
AA1%+SS1%	+++	+++	+++	+++	+	+++
Ialugen plus	+++	+++	+++	+++	+++	+++
Acticoat	+++	+++	+++	+++	+	+++
Aquacel Ag	+++	+++	+++	0	+	+
Actilite	0	0	+++	0	0	+
Betadine	+++	+	+++	+++	+++	+++
MODEL C	*P. aeruginosa 1*	*P. aeruginosa 2*	*S. aureus*	*E. coli*	*E. faecalis*	*A. baumannii*
AA1%	+	0	0	0	0	+
FUR0,2%	0	0	0	0	0	0
Aqvitox-D	0	0	0	0	0	0
Octenisept	+	+	+++	+++	0	+
SS1%	0	0	0	0	0	0
AA1%+SS1%	0	+	0	0	0	+
Ialugen plus	0	0	0	0	0	+
Acticoat	0	0	0	0	0	0
Aquacel Ag	+	+	+++	0	0	0
Actilite	0	0	0	0	0	+
Betadine	0	0	+++	+++	0	+

Interpretation of Results for Efficacy of Topical Antimicrobial Agents

0	No antimicrobial activity
	CFU following treatment equals CFU in gauze control

+	Bacteriostatic effect
	The number of CFU after the action of the agent is lower than after the application of sterile gauze and at the same time higher than the initial inoculum

+++	Strong bactericidal effect
	The number of CFU after the action of the agent is lower than the initial inoculum

Intensity of Biofilm Formation in Tested Wound Pathogens

Nr.	Identification	4 h	6 h	24 h
1	P. aeruginosa A	+	+	+++
2	P. aeruginosa B	+	+	+++
3	S. aureus	0	+	+
4	E. faecalis	0	+	++
5	E. coli	0	+	++
6	A. baumannii	+	+	+++

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DOI: https://doi.org/10.2478/afpuc-2026-0004 | Journal eISSN: 2453-6725

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Language: English

Submitted on: Apr 20, 2026

Accepted on: May 15, 2026

Published on: Jun 24, 2026

Published by: Comenius University in Bratislava, Faculty of Pharmacy

In partnership with: Paradigm Publishing Services

Keywords:

biofilm,

topical antimicrobials,

wound healing

Related subjects:

Pharmacy,

Pharmacy, other

© 2026 Marianna Hajská, Peter Záhorec, Arpád Panyko, Martin Dubovský, Škanderová Martina, Marián Vidiščák, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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