Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
Figure 6.
Effect of 2 months storage at 4 °C on particle size and polydispersity index_
| BSLN | DSLN1 | DSLN2 | DSLN3 | DSLN4 | |
|---|---|---|---|---|---|
| Particle size (nm) | 61.8±0.2 | 406.5 ±8.8 | 159.7 ±2.5 | 139.6 ±0.9 | 123.7 ±2.6 |
| Polydispersity index | 0.079 ±0.003 | 0.472 ±0.020 | 0.189 ±0.007 | 0.208 ±0.008 | 0.205 ±0.003 |
Drug loading and entrapment for docetaxel-based nanoparticles_
| Formulation | Entrapment efficiency (%) | Drug loading capacity (%) |
|---|---|---|
| DSLN1 | 73.00 ± 3.0 | 9.30 ± 0.35 |
| DSLN2 | 80.00 ± 2.0 | 10.20 ± 0.13 |
| DSLN3 | 84.00 ± 3.0 | 10.80 ± 0.09 |
| DSLN4 | 81.20 ± 2.0 | 10.40 ± 0.06 |
Flux and permeability coefficient of DTX entrapped in lipid nanoparticles across dialysis membrane_
| Batch | Flux, J (μg/cm2 h) | Permeability coefficient (cm h−1) |
|---|---|---|
| DTX | 0.8482±0.0154 | 0.00033928±0 |
| DSLN1 | 0.748±0.0181 | 0.0002992±0 |
| DSLN3 | 0.8276±0.0227 | 0.00033104±0 |
| DSLN4 | 0.7032± 0.0236 | 0.00028128±0 |
Formulation of docetaxel solid lipid nanoparticles_
| Ingredient | BSLN | DSLN1 | DSLN2 | DSLN3 | DSLN4 |
|---|---|---|---|---|---|
| Docetaxel | --- | 5 mg | 5 mg | 5 mg | 5 mg |
| Rubone | --- | --- | 15 μg | 20 μg | 20 μg |
| Cetyl palmitate | 20 mg | 20 mg | 20 mg | 20 mg | 20 mg |
| PC | 5 mg | 5 mg | 5 mg | 5 mg | 5 mg |
| Brij O10 | 10 mg | 10 mg | 10 mg | 10 mg | 10 mg |
| Soluplus | 20 mg | 20 mg | 20 mg | 20 mg | 20 mg |
| LHRH | --- | --- | --- | --- | 20 μg |
| Water qs | 2 mL | 2 mL | 2 mL | 2 mL | 2 mL |
Particle size, polydispersity index, zeta potential, and conductivity_
| Formulation | Particle size (nm) | Polydispersity index | Zeta potential (mV) | Conductivity (mS/cm) |
|---|---|---|---|---|
| BSLN | 63.26±3.0 | 0.087±0.01 | −14.53±2.0 | 0.087 ± 0.002 |
| DSLN1 | 174.93±3.0 | 0.344±0.06 | −14.33±0.5 | 0.091±0.001 |
| DSLN2 | 148.03±4.0 | 0.201±0.01 | −8.2±0.3 | 0.161±0.002 |
| DSLN3 | 125.77±3.0 | 0.237±0.01 | −9.27±0.2 | 0.113±0.001 |
| DSLN4 | 174.87±5.0 | 0.393±0.02 | −7.35±2.2 | 0.115±0.002 |