Figure 1.
Figure 2.
Figure 3.
Figure 4.
Effects of peptides sum and prednisolone on biochemical blood parameters in experimental cotton wool granuloma_
| Biochemical parameters | Control | Prednisolone (10 mg/kg) | Peptides sum (10−6 mg/kg) | Peptides sum (10−4 mg/kg) |
|---|---|---|---|---|
| Glucose (mmol/L) | 6.15 ± 0.13 | 5.97 ± 0.15 | 4.93 ± 0.59 | 4.83 ± 0.13 |
| ALT (U/L) | 72.3 ± 3.93 | 56.7 ± 4.18* | 47.0 ± 6.57** | 61.3 ± 2.97* |
| AST (U/L) | 140.7 ± 3.18 | 154.7 ± 11.1 | 147.7 ± 11.7 | 150.3 ± 16.2 |
| Total protein (g/L) | 70.2 ± 1.59 | 64.8 ± 1.91 | 76.0 ± 1.16 | 72.3 ± 0.33 |
| Bilirubin (μmol/L) | 4.2 ± 0.66 | 4.17 ± 0.81 | 4.47 ± 0.97 | 4.2 ± 7.0 |
| Creatinine (μmol/L) | 42.9 ± 1.91 | 38.7 ± 1.35 | 45.0 ± 2.0 | 48.0 ± 3.8 |
| Urea (mmol/L) | 6.8 ± 0.89 | 6.33 ± 0.93 | 6.23 ± 0.45 | 7.87 ± 1.43 |
| CRP (mg/L) | 30.0 ± 0.4 | 29.0 ± 1.5 | 28.0 ± 0.7 | 26.0 ± 0.9 |
| ASO (mmol/mL) | 23.77 ± 7.2 | 10.9 ± 1.64* | 10.0 ± 0.06* | 9.47 ± 0.47* |
Molecular masses of peptides isolated from the substance peptides sum_
| Sequence | MM | Accession | Protein name |
|---|---|---|---|
| RVGAGAPVYLAAVLEYLTAEILELAGNAARD | 2915.588 | 28195394 | Histone cluster 2, H2ab |
| KFFSAVSTVLTSKY | 1286.7 | 122405 | Hemoglobin alpha chain |
| RAGLQFPVGRI | 944.532 | 4504255 | H2A histone family, member Z |
| RLLVVYPWTQRF | 1274.726 | 4504351 | Delta globin |
| KVNVDEVGGEALGRL | 1314.665 | 4504349 | Beta globin |
| KSAVTALWGKV | 932.52 | 4504349 | Beta globin |
| KSLVSGLWGKV | 946.536 | 57113367 | Similar to beta globin |
| KVFLENVIRD | 989.578 | 817960 | Histone H4 (55AA) |
| RLLLPGELAKH | 953.604 | 1568557 | Histone H2B |
| RISGLIYEETRG | 1180.621 | 4504301 | Histone cluster 1, H4a |