Table 1.
Molecular masses of peptides isolated from the substance peptides sum.
| Sequence | MM | Accession | Protein name |
|---|---|---|---|
| RVGAGAPVYLAAVLEYLTAEILELAGNAARD | 2915.588 | 28195394 | Histone cluster 2, H2ab |
| KFFSAVSTVLTSKY | 1286.7 | 122405 | Hemoglobin alpha chain |
| RAGLQFPVGRI | 944.532 | 4504255 | H2A histone family, member Z |
| RLLVVYPWTQRF | 1274.726 | 4504351 | Delta globin |
| KVNVDEVGGEALGRL | 1314.665 | 4504349 | Beta globin |
| KSAVTALWGKV | 932.52 | 4504349 | Beta globin |
| KSLVSGLWGKV | 946.536 | 57113367 | Similar to beta globin |
| KVFLENVIRD | 989.578 | 817960 | Histone H4 (55AA) |
| RLLLPGELAKH | 953.604 | 1568557 | Histone H2B |
| RISGLIYEETRG | 1180.621 | 4504301 | Histone cluster 1, H4a |
Figure 1.
Preventive effect of the peptides sum on the dynamics of inflammation in rats bearing carrageenan edema model (increase in the volume of the limbs, % relative to the initial one, n = 6).
Figure 2.
Effect of the peptides sum, ASA, and prednisolone on the dynamics of inflammation in rats on the model of exudative inflammation induced by carrageenan (increase in the volume of the limbs, % relative to the initial one, n = 6). (a) Increase in paw volume 3 h after induction, %. (b) Anti-exudative activity, %. *P £ 0.05, **P £ 0.01, ***P £ 0.005. ASA, acetylsalicylic acid.
Figure 3.
The therapeutic effect of the peptides sum on the dynamics of inflammation in rats bearing exudative inflammation induced by carrageenan (increase in the volume of the limbs, % relative to the initial one, n = 6).
Figure 4.
The effect of the sum peptides on the dynamics of inflammation in rats using a model of exudative inflammation induced by formalin (increase in the volume of the limbs, % relative to the initial one, n = 6).
Table 2.
Effects of peptides sum and prednisolone on biochemical blood parameters in experimental cotton wool granuloma.
| Biochemical parameters | Control | Prednisolone (10 mg/kg) | Peptides sum (10−6 mg/kg) | Peptides sum (10−4 mg/kg) |
|---|---|---|---|---|
| Glucose (mmol/L) | 6.15 ± 0.13 | 5.97 ± 0.15 | 4.93 ± 0.59 | 4.83 ± 0.13 |
| ALT (U/L) | 72.3 ± 3.93 | 56.7 ± 4.18* | 47.0 ± 6.57** | 61.3 ± 2.97* |
| AST (U/L) | 140.7 ± 3.18 | 154.7 ± 11.1 | 147.7 ± 11.7 | 150.3 ± 16.2 |
| Total protein (g/L) | 70.2 ± 1.59 | 64.8 ± 1.91 | 76.0 ± 1.16 | 72.3 ± 0.33 |
| Bilirubin (μmol/L) | 4.2 ± 0.66 | 4.17 ± 0.81 | 4.47 ± 0.97 | 4.2 ± 7.0 |
| Creatinine (μmol/L) | 42.9 ± 1.91 | 38.7 ± 1.35 | 45.0 ± 2.0 | 48.0 ± 3.8 |
| Urea (mmol/L) | 6.8 ± 0.89 | 6.33 ± 0.93 | 6.23 ± 0.45 | 7.87 ± 1.43 |
| CRP (mg/L) | 30.0 ± 0.4 | 29.0 ± 1.5 | 28.0 ± 0.7 | 26.0 ± 0.9 |
| ASO (mmol/mL) | 23.77 ± 7.2 | 10.9 ± 1.64* | 10.0 ± 0.06* | 9.47 ± 0.47* |