Abstract
Enzymatic hydrolysates of proteins isolated from cow lungs are used as anti-inflammatory agents for the growth and regeneration of new tissues. Hydrolysates were observed to inhibit the production of free radicals in cells and have a high anti-exudative activity even in low doses. In this study, we established the anti-exudative activity of peptides of protein hydrolysates isolated from bovine lungs. The anti-exudative activity of the peptides sum was compared with acetylsalicylic acid (ASA) and prednisolone, and the dynamics of inflammation were studied by tumour formation using carrageenan and formalin. Between 1 h and 24 h after administration of the drug, the effect of the peptides sum showed a significantly better indicator than the rest of the means. In general, the anti-exudative activity of the peptides sum was 2–3 times higher than the rest of the preparations. Biochemical indicators of prednisolone and peptides sum in two doses of 10−6 μg/kg and 10−4 μg/kg were studied. As a result of the study, it was found that the peptides sum at 10−6 μg/kg dose enhanced alanine aminotransferase (ALT) activity by 17.1% compared to those resulting from prednisolone treatment. In C-reactive protein (CRP) and antistreptolysin O (ASO) indicators, 10−4 μg/kg dose showed high activity. The sum of isolated peptides reduced ALT and ASO levels. This study provides additional support for preparing anti-inflammatory means from the peptides sum isolated from bovine lungs.