Figure 1.
Formulation of Paracetamol Tablets_
| Ingredients | Concentration (%w/w) | ||
|---|---|---|---|
| F1 | F2 | F3 | |
| Paracetamol | 77 | 77 | 77 |
| Avicel pH 102 | 5 | 5 | 5 |
| Unmodified WS | 6 | - | - |
| Pre-gelatinized WS | - | 6 | - |
| Phosphorylated WS | - | - | 6 |
| Talc | 2 | 2 | 2 |
| Magnesium stearate | 1 | 1 | 1 |
| Lactose | 9 | 9 | 9 |
Characteristics of Modified and Unmodified Water yam Starch (WS) Powder
| No | Powder Characteristics | Unmodified WS | Pre-gelatinized WS | Phosphorylation WS |
|---|---|---|---|---|
| 1 | Loss on drying (%) | 6.45±0.69 | 4.04±0.18 | 3.04±0.09 |
| 2 | Moisture content (%) | 6.89±0.80 | 4.12±0.19 | 3.13±0.10 |
| 3 | Tapped density (g / ml) | 0.60±0.02 | 0.54±0.02 | 0.60±0.02 |
| 4 | Apparent density (g / ml) | 2.50±0.47 | 1.00±0.12 | 1.28±0.03 |
| 5 | Bulk density (g / ml) | 0.43±0.01 | 0.48±0.01 | 0.54±0.02 |
| 6 | Porosity (%) | 82.53±2.80 | 50.95±7.73 | 58.24±0.63 |
| 7 | Hausner ratio | 1.40±0.04 | 1.11±0.00 | 1.12±0.00 |
| 8 | Flow rate (g / s) | Does not flow | 5.53±0.01 | 4.05±0.05 |
| 9 | Compressibility index (%) | 28.56±2.24 | 9.68±0.27 | 10.72±0.34 |
| 10 | Swelling power | 3.65±1.15 | 3.81±3.06 | 5.09±4.16 |
Physical properties of paracetamol tablet
| Testing | Formula | ||
|---|---|---|---|
| F1 | F2 | F3 | |
| Weight (mg) | 603.15±1.95 | 606.05±1.32 | 610.75±1.58 |
| Diameter (mm) | 12.12±0.04 | 12.10±0.02 | 12.10±0.01 |
| Thickness (mm) | 4.58±0.09 | 4.54±0.11 | 4.62±0.10 |
| Hardness (Kgf) | 5.20±0.11 | 6.42±0.09 | 7.81±0.08 |
| Friability (%) | 0.79±0.06 | 0.38±0.02 | 0.24±0.03 |
| Disintegration time (minute) | 1.88±0.73 | 8.04±0.97 | 12.45±0.80 |
Determination of Amylose and Amylopectin content of WS
| Water yam starch (WS) | Amylose (%) (x̄μ ± SD) | Amylopectin (%) (x̄ ± SD) |
|---|---|---|
| Unmodified WS | 11.92±0.61 | 88.08±0.61 |
| Pre-gelatinized WS | 10.41±0.90 | 89.59±0.90 |
| Phosphorylation WS | 12.61±1.75 | 87.39±1.75 |