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DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids Cover

DNA Cleavage and Cytotoxic Activity of Copper(II) Complexes Based on Reduced Schiff Bases Derived From Salicylaldehyde and Amino Acids

European Pharmaceutical Journal
Volume 70 (2023): Issue s2 (December 2023)
By: Jana Korcová,  Mária Húserková,  Lucia Lintnerová and  Jindra Valentová  
Open Access
|Mar 2024

Figures & Tables

Fig. 1.

DNA cleavage activity of LL2 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL2 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL2 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL2 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 2.

DNA cleavage activity of LL3 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL3 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL3 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL3 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 3.

DNA cleavage activity of LL4 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL4 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL4 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL4 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Fig. 4.

DNA cleavage activity of LL5 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL5 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.
DNA cleavage activity of LL5 complex after 5h/37°C incubationLine 1: C- negative control (pBR 322 in TRIS-HCl, pH 7.5)Line 2-4: LL5 in the concentration of 1×10−3, 3×10−3, 5×10−3 added to pBR 322.

Figure 5.

Cytotoxic activity of copper(II) complexes. Expressed as a percentage of the amount of untransformed resazurin to resorufin after 3 h of incubation with copper(II) complexes. Comparison with C+ control was performed by t-test Significance levels: ***0.000 < P < 0.001; **0.001 < P < 0.01; *0.01 < P < 0.05
Cytotoxic activity of copper(II) complexes. Expressed as a percentage of the amount of untransformed resazurin to resorufin after 3 h of incubation with copper(II) complexes. Comparison with C+ control was performed by t-test Significance levels: ***0.000 < P < 0.001; **0.001 < P < 0.01; *0.01 < P < 0.05

j_afpuc-2024-0003_tab_001

WavelenghtResorufin ɛREDResazurin ɛOX
570 nm155,67780,586
600 nm14,652117,216
DOI: https://doi.org/10.2478/afpuc-2024-0003 | Journal eISSN: 2453-6725
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Language: English
Page range: 48 - 51
Submitted on: Oct 9, 2023
Accepted on: Feb 15, 2024
Published on: Mar 28, 2024
Published by: Comenius University in Bratislava, Faculty of Pharmacy
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
copper(II) complexes,
anticancer drugs,
DNA cleavage activity,
cytotoxicity
Related subjects:
Pharmacy,
Pharmacy, other

© 2024 Jana Korcová, Mária Húserková, Lucia Lintnerová, Jindra Valentová, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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