Table 1.
Eye drops A composition.
| Dexamethasone | 0.05 g |
| Sodium chloride | 0.399 g |
| Carbethopendecinium bromide | 2.5 g |
| Water for injections | ad 50.0 g |
Table 2.
Eye drops C composition.
| Dexamethasone sodium phosphate | 0.1 g |
| Sodium chloride | 0.799 g |
| Carbethopendecinium bromide | 1.08 g |
| Water for injections | ad 100.0 g |
Table 3.
Eye drops B composition (with chitosan).
| Dexamethasone | 0.05 g |
| Chitosan LMW | 0.05 g |
| Lactic acid 80% | 0.5 g |
| Water for injections | ad 50.0 g |
| Sodium hydroxide | q.s. |
Table 4.
Eye drops D composition (with chitosan).
| Dexamethasone sodium phosphate | 0.1 g |
| Chitosan LMW | 0.1 g |
| Lactic acid 80% | 1.0 g |
| Water for injections | ad 100.0 g |
| Sodium hydroxide | q.s. |
Table 5.
Measured pH values of eye drops, the density of eye drops (pycnometrically), and their surface tension (stalagmometrically) – an average of six measurements.
| Eye drops | pH | Density (g cm−3) | Surface tension (N m−1) |
|---|---|---|---|
| A | 6.626 | 1.0088 | 70.9313 |
| B (Ch) | 5.878 | 0.9953 | 70.5043 |
| C | 7.400 | 1.0059 | 35.0392 |
| D (Ch) | 5.800 | 1.0030 | 63.3394 |
| Unidexa 0.1% | 6.757 | 1.0094 | 36.9939 |
Figure 1.
The viscosity of eye drops A, B, C, D and Unidexa depending on torque (n = 3).
Table 6.
Compositions of solutions for monitoring hemolysis.
| Composition of solutions (ml) | The concentration of NaCl solutions (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1.0% | 0.9% | 0.8% | 0.7% | 0.6% | 0.5% | 0.4% | 0.3% | 0.2% | 0.1% | |
| 1% NaCl solution | 4.5 | 4.0 | 3.5 | 3.0 | 2.5 | 2.0 | 1.5 | 1.0 | 0.5 | 0 |
| Water for injections | 0 | 0.5 | 1.0 | 1.5 | 2.0 | 2.5 | 3.0 | 3.5 | 4.0 | 4.5 |
| RBC suspension | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
Figure 2.
Hemolysis in different NaCl solutions.
Figure 3.
Absorbance of different NaCl solutions at 550 nm.
Figure 4.
Absorbance of different eye drops at 550 nm.