Figure 1.
Figure 2.
The final composition of the tablets_
| Component/formulation | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| Glyceryl laurate (%) | 35.40 | 35.40 | 35.40 | 35.40 |
| Sucrose laurate/Ryoto (g) | 2.42 | - | 2.42 | - |
| Sucrose ester/Sisterna (g) | - | 2.42 | - | 2.42 |
| Sorbitol (%) | 9.70 | 9.70 | 9.70 | 9.70 |
| Amino acetic acid (%) | 0.49 | 0.49 | 0.49 | 0.49 |
| Lactic acid (%) | 0.49 | 0.49 | 0.49 | 0.49 |
| Talc (%) | 1.20 | 1.20 | 1.20 | 1.20 |
| Magnesium stearate (%) | 0.30 | 0.30 | 0.30 | 0.30 |
| Microcryst. cellulose (%) | 50.00 | 50.00 | 50.00 | 50.00 |
| Granule size (mm) | <1.25 | <1.25 | <4 | <4 |
The preparation of the granules_
| Ingredient | Mixture A1 | Mixture A2 | Mixture B |
|---|---|---|---|
| Glyceryl laurate (g) | 54.75 | 54.75 | 54.75 |
| Sucrose laurate/Ryoto (g) | 7.50 | - | - |
| Sucrose ester/Sisterna (g) | - | 7.50 | - |
| Sorbitol (g) | 15.00 | 15.00 | 15.00 |
| Lactic acid (g) | - | - | 1.50 |
| Amino acetic acid (g) | - | - | 1.50 |