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Thin-layer hydration method to prepare a green tea extract niosomal gel and its antioxidant performance Cover

Thin-layer hydration method to prepare a green tea extract niosomal gel and its antioxidant performance

Open Access
|Oct 2021

Figures & Tables

Figure 1

Scanning electron micrographs of the morphology of green tea extract niosome system at a magnification of (A) 1000×; (B) 2000× and (C) 5000×.
Scanning electron micrographs of the morphology of green tea extract niosome system at a magnification of (A) 1000×; (B) 2000× and (C) 5000×.

Figure 2

The organoleptic of niosome gel preparations at a niosome concentration of (A) 30%, (B) 40%, and (C) 50%.
The organoleptic of niosome gel preparations at a niosome concentration of (A) 30%, (B) 40%, and (C) 50%.

Figure 3

The organoleptic of niosome gel preparation at 4°C on (A) day 1 and (B) day 30; at 40°C on (C) day 1 and (D) day 30 shown the same consistency, brown color and distinctive fragrance of green tea as before storage.
The organoleptic of niosome gel preparation at 4°C on (A) day 1 and (B) day 30; at 40°C on (C) day 1 and (D) day 30 shown the same consistency, brown color and distinctive fragrance of green tea as before storage.

Figure 4

Rheological behavior of green tea extract niosome gel preparation.
Rheological behavior of green tea extract niosome gel preparation.

Antioxidant activity of green tea extract gel_

Formula% inhibition
Green tea extract gel 30%17.78 ± 1.49
Green tea extract gel 40%19.69 ± 1.14
Green tea extract gel 50%27.09 ± 1.57

Physical and chemical characteristics of green tea extract niosome gel preparation_

FormulaViscosity (Cps)pHSpreadability (g/cm)
Green tea niosome gel 30%292.667 ± 1.1556.68 ± 0.030.0051 ± 0.0004
Green tea niosome gel 40%297.333 ± 1.1156.59 ± 0.100.0050 ± 0.0003
Green tea niosome gel 50%306.667 ± 2.3096.68 ± 0.010.0040 ± 0.0004

Irritation test results of green tea extract niosome gel

FormulaTreatmentIrritation Score
BeforeAfter
SLS (positive control)10.63 (Strong irritation)
Aquadest (negative control)0 (No irritation)
Green tea extract niosome gel 30%0 (No irritation)
Green tea extract niosome gel 40%0 (No irritation)
Green tea extract niosome gel 50%0 (No irritation)

Composition of green tea (C_ sinensis) extract niosomes_

MaterialComposition
Span 6012.6 gram
Tween 6019.62 gram
Cholesterol1.74 gram
PEG 40090.0 gram
Green Tea Extract60.0 gram
Sodium Benzoate0.6 gram
Distilled waterto 600 ml

The composition of green tea extract niosome gel_

MaterialComposition (%) (w/w)
Green tea extract niosome304050
Sodium alginate555
CaCl20.20.20.2
Propylene glycol101010
Methylparaben0.10.10.1
Green tea fragrancesufficientlysufficientlysufficiently
Distilled waterto 100to 100to 100

The pH value of green tea extract niosome gel preparations_

Fomula1st dayFreeze-thaw4°C30°C40°C
Green tea extract niosome gel 30%6.68 ± 0.036.16 ± 0.066.52 ± 0.026.02 ± 0.196.01 ± 0.03
Green tea extract niosome gel 40%6.59 ± 0.106.17 ± 0,026.52 ± 0.036.06 ± 0.046.02 ± 0.02
Green tea extract niosome gel 50%6.68 ± 0.016.18 ± 0,106.50 ± 0.076.04 ± 0.105.96 ± 0.06

Antioxidant activity of green tea extract niosome gel_

Formula% inhibition
Green tea extract niosome gel 30%10.04 ± 0.05
Green tea extract niosome gel 40%17.49 ± 0.03
Green tea extract niosome gel 50%25.13 ± 0.05

The characteristics of green tea extract niosomes obtained from Malvern Zetasizer Nano_

NiosomeZ-Average diam. (nm)Polydispersity IndexZeta potential (mV)Entrapment efficiency (%)
Mean11090.856−0.61689.74
Standard Deviation± 63± 0.057± 0.068± 2.52
Language: English
Page range: 125 - 135
Submitted on: Dec 14, 2020
Accepted on: Jun 29, 2021
Published on: Oct 13, 2021
Published by: Comenius University in Bratislava, Faculty of Pharmacy
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
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© 2021 U. Chasanah, N. Mahmintari, F. Hidayah, F.A. El Maghfiroh, D. Rahmasari, R. Weka Nugraheni, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.