Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid

Comp. Nr.	Starting metal salt	Yield	Colour	Molar conductivity	Assumed composition	Elemental analysis theor.		Elemental analysis exp.
		%		μS·mol⁻¹·cm²		% C	% H	% C	%H
1	CoCl₂·6H₂O	96	pink	9	Co(L-2H)(2H₂O)	51.84	8.31	51.70	8.55
2	CuCl₂·2H₂O	75	light blue	3	Cu(L-2H)(2H₂O)	51.44	8.25	51.17	8.03
3	NiCl₂·6H₂O	82	light-green	10	Ni(L-2H)(3H₂O)	50.17	8.43	50.19	8.46
4	La(NO₃)₃·6H₂O	87	white	2	La(L-3H)(2H₂O)	44.90	7.02	44.91	7.19
5	VOSO₄·5H₂O	84	grey-blue	11	VO(L-2H)(3H₂O)	49.34	8.28	49.30	8.03
6	FeCl₃·6H₂O	86	light-brown	3	Fe(L-3H)(3H₂O)	50.46	8.28	50.50	7.95
7	MnCl₂·2H₂O	95	brownish-white	5	Mn(L-2H)(2H₂O)	52.27	8.37	52.79	8.30

Characteristic signals in IR and HR-MS spectra.

Substance	ν_as(COO⁻) ^a	ν_s(COO⁻) ^b	Δν(COO⁻) ^c	ν(C=O)	m/z theor. ^d	m/z found
1 (Co)	1590	1394	196	1704	472.1872	472.1875
2 (Cu)	1567	1417	150	1704	476.1836	476.1839
3 (Ni)	1575	1417	158	1704	471.1893	471.1899
4 (La)	1558	1403	155	---	(552.1603)	---
5 (V)	1563	1423	140	1705	480.1928	480.1932
6 (Fe)	1539	1440	99	---	468.1811	468.1816
7 (Mn)	1569	1409	160	1703	(468.1920)	---
8 (L)	---	---	---	1691	415.2696	415.2701

a V_as(COO⁻): asymmetric stretching vibration of the carboxyl;

b V_s(COO⁻): symmetric stretching vibration of the carboxyl;

c ΔV(COO⁻) = V_as(COO⁻) - V_s(COO⁻);

d the composition assigned to pseudomolecular ion was in all cases [M(L-nH)]⁻, where n = 3–4, depending on the charge of the metal cation

Antimicrobial activity of metal carboxylates and the ligand (MIC = minimum inhibitory concentration).

DOI: https://doi.org/10.2478/afpuc-2020-0018 | Journal eISSN: 2453-6725 (formerly 1338-6786) | Journal ISSN: 0301-2298

Language: English

Page range: 46 - 53

Submitted on: Nov 13, 2020

Accepted on: Mar 1, 2021

Published on: Jul 25, 2021

Published by: Comenius University in Bratislava, Faculty of Pharmacy

In partnership with: Paradigm Publishing Services

Keywords:

Related subjects:

© 2021 L. Habala, L. Pašková, A. Bilková, F. Bilka, B. Oboňová, J. Valentová, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figures & Tables