Have a personal or library account? Click to login

Proportion of Pit-1 Gene Hinfi Polymorphism in Different Cattle Breeds: A Meta-Analysis

Open Access
|Sep 2025

References

  1. Brito LF, Oliveira HR, McConn BR, Schinckel AP, Arrazola A, Marchant-Forde JN, Johnson JS: Large-Scale Phenotyping of Livestock Welfare in Commercial Production Systems: A New Frontier in Animal Breeding. Front Genet 2020, 11:793.
  2. Gutierrez-Reinoso MA, Aponte PM, Garcia-Herreros M: Genomic Analysis, Progress and Future Perspectives in Dairy Cattle Selection: A Review. Animals 2021, 11(3):599.
  3. Hoseinzadeh Z, Mohammadabadi M, Esmailizadeh AK, Khezri A: Association of Pit-1 gene and milk protein percentage in Holstein cattle. J Livest Sci Technol 2015, 41-49.
  4. Gebrehiwot NZ, Strucken EM, Marshall K, Aliloo H, Gibson JP: SNP panels for the estimation of dairy breed proportion and parentage assignment in African crossbred dairy cattle. Genet Sel Evol 2021, 53(21).
  5. Trakovická A, Moravčíková N, Gábor M, Miluchová M: Genetic polymorphism of Pit-1 gene associated with milk production traits in Holstein cattle. Acta Agr Kapos 2014, 18(1):146-151.
  6. Aytekin I, Fadhıl M: Pit-1 Gene Polymorphisms in Anatolian Black, Holstein Friesian, Brown Swiss and Simmental Cattle Reared in Turkey. J Agric Sci 2022, 28(1):139-144..
  7. Shen JF, Chen QM, Zhang FW, Hanif Q, Huang BZ, Chen NB, Qu KX, Zhan JX, Chen H, Jiang Y, Lei CZ: Genome-wide association study identifies quantitative trait loci affecting cattle temperament. Zool Res 2022, 43(1):14-25.
  8. Mattos KK de, Del Lama SN, Martinez ML, Freitas AF: Association of bGH and Pit-1 gene variants with milk production traits in dairy Gyr bulls. Pesqui Agropecu Bras 2004, 39(2):147-150.
  9. Khaizaran ZA, Al-Razem F: Analysis of selected milk traits in Palestinian Holstein-Friesian cattle in relation to genetic polymorphism. J Cell Anim Biol 2014, 8(5):74-85.
  10. Li Q: Responses of Bovine Pituitary Transcriptome Profiles to Consumption of Toxic Tall Fescue and Forms of Selenium in Vitamin-mineral Mixes, Ph.D. Thesis, Lexington, University of Kentucky, 2019.
  11. Parmentier I, Portetelle D, Gengler N, Prandi A, Bertozzi C, Vleurick L, Gilson R, Renaville R: Candidate gene markers associated with somatotropic axis and milk selection. Domest Anim Endocrinol 1999, (2-3):139-148a.
  12. Zakizadeh S, Reissmann M, Rahimi G, Ardeshir NJ, Reinecke P, Mirae-Ashtiani S, Moradi Shahrbabak M: Analysis of POUF1 gene polymorphism in three Iranian Native and the Holstein cattle by PCR-RFLP. In: Proccedings of 8. World Congress on Genetics Applied to Livestock Production, Brasil, 2006.
  13. Othman OE, Zayed FA, El-Gawead AA, El-Rahman MRA: Genetic polymorphism of three genes associated with milk trait in Egyptian buffalo. J Genet Eng & Biotechnol 2011, (9):97-102.
  14. Carsai TC, Bâlteanu VA, Vlaic A, Cosier V: The polymorphism of pituitary factor 1 (POU1F1) in cattle, Scientific Papers Animal Science and Biotechnologies 2012, 45(1):142-146.
  15. Pytlewski J, Antkowiak I, Czerniawska-Piątkowska E: Prelationship of Pit-1 gene polymorphism with breeding parameters and body weights of cows and calves. Pak J Zool 2018, 50(1):183-187.
  16. Renaville R, Gengler N, Vrech E, Prandi A, Massart S, Corradini C, Bertozzi C, Mortiaux F, Burny A, Portetelle D: Pit-1 gene polymorphism, milk yield, and conformation traits for Italian Holstein-Friesian bulls, J Dairy Sci 1997, 80(12):3431-3438.
  17. Dybus A, Szatkowska I, Czerniawska-Piątkowska E, Grzesiak W, Wójcik J, Rzewucka E, Zych, S: Pit-1/HinfI gene polymorphism and its associations with milk production traits in Polish Black-and-White cattle, Archiv fur Tierzucht 2004, 47:557-563.
  18. Moody De, Pomp D, Barendse W: Restriction fragment length polymorphism in amplification products of the bovine Pit-1 gene and assignment of Pit-1 to bovine chromosome 1. Anim Genet 1995, 26:45-47.
  19. Sakar ÇM, Zülkadir U: Determination of the relationship between Anatolian black cattle growth properties and myostatin, GHR and Pit-1 gene. Anim Biotechnol 2021, 33(3):536-545.
  20. Dybus A, Kmieć M, Sobek Z, Pietrzyk W, Wiśniewski B: Associations between polymorphisms of growth hormone releasing hormone (GHRH) and pituitary transcription factor 1 (Pit-1) genes and production traits of Limousine cattle. Arch für Tierz 2003, 46(6):527-534.
  21. Carrijo SM, De Alencar MM, Toral FLB, Regitano LCDA: Association of Pit-1 genotypes with growth traits in Canchim cattle. Sci Agric 2008, 65:116-121.
  22. Tang L, Yang D, Ouyang W, Zhang L, Lan X, Zhang C, Zhang R, Zhang A, Zhang L: Chen H Association of polymorphisms in the Pit-1 intron 5 with body measurements in Chinese Cattle. Afr J Biotechnol 2012, 11(42):9906-9910.
  23. Renaville R, Gengler N, Parmentier I, Mortiaux F, Massart S, Bertozzi C, Burny A, Portetelle D: Pit-1 gene HinfI RFLP and growth traits in double-muscled Belgian Blue cattle. J Anim Sci 1997, 75: 46-147.
  24. Oprzadek J, Flisikowski K, Zwierzchowski L, Dymnicki E: Polymorphisms at loci of Leptin (LEP), Pit-1 and STAT5A and their association with growth, feed conversion and carcass quality in Black-and – White bulls. Anim Sci Pap Rep 2003, 21:135-145.
  25. Vargas LD, Gana VE, Escudero IF: Pit-1 gene polymorphism in dairy cows from Central Chile. Archivos de Zootecnia 2004, 53:217-220.
  26. Xue K, Chen H, Wang S, Cai X, Liu B, Zhang CF, Lei CZ, Wang XZ, Wang YM, Niu H: Effect of genetic variations of the POU1F1 gene on growth traits of Nanyang cattle. Acta Genet Sin 2006, 33:901-907.
  27. Zhang C, Liu B, Chen H, Lan X, Lei C, Zhang Z, Zhang R: Associations of a HinfI PCRRFLP of POU1F1 gene with growth traits in Qinchuan cattle. Anim Biotechnol 2009, 20(2):71-74.
  28. Zwierzchowski L, Krzyżewski J, Strzałkowska N, Siadkowska E, Ryniewicz Z: Effects of polymorphism of growth hormone (GH), Pit-1, and leptin (LEP) genes, cow’s age, lactation stage and somatic cell count on milk yield and composition of Polish Black-and-White cows. Animal Sci Pap Rep 2002, 20(4):213-227.
  29. Zhao Q, Davis ME, Hines HC: Associations of polymorphisms in the Pit-1 gene with growth and carcass traits in Angus beef cattle. J Anim Sci 2004, 82(8):2229-33.
  30. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D: The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021, 372:71.
  31. Parmentier I, Portetelle D, Gengler N, Prandi A, Bertozzi C, Vleurick L, Gilson R, Renaville R: Candidate gene markers associated with somatotropic axis and milk selection. Domest Anim Endocrinol 1999, 17:139-148.
  32. Heidari M, Azari MA, Hasani S, Khanahmadi A, Zerehdaran S: Effect of polymorphic variants of GH, Pit-1, and β-LG genes on milk production of Holstein cows. Genetica 2012, 48(4):503-507.
  33. Sadeghi M, Mokhber M, Shahrbabak MM: Association of Pit-1 gene polymorphism with milk production traits in Iranian proved Holsteins. In: Proceedings of the Second International and Sixth National Conference of Organic vs Conventional Agriculture, Ardabili, 2019.
  34. Trakovická A, Moravčíková N, Minarovic T, Navrátilová A: SNPs analyses of the bovine LEP and PIT-1 genes by multiplex PCR-RFLP method and their effect on milk performance traits in Slovak Simmental cattle. J Cent Eur Agric 2015, (16):65-75.
  35. Ilie DE, Mizeranschi AE, Mihali CV, Neamt RI, Carabaş M, Grădinaru AC: The effect of genetic variations of pituitary transcription factor 1 (PIT1) on milk performance traits in Romanian cattle. Rev Rom Med Vet 2021, 31(1): 7-92.
  36. Korkmaz M, Akyüz M: Investigation of the Relationship between GH and PIT-I Gene Polymorphisms and Milk Yields in Simmental Cattle Breed. KSU J Agric Nat 2020, 23(6):1678-1686.
  37. Jawasreh KIZ, Awaedeh F, Rawashdeh I, Faiq H, Miassar A: The allele and genotype frequencies of bovine pituitary specific transcription factor and leptin genes in Jordanian cattle population by using PCR-RFLP. Aust J Basic Appl Sci 2009, 3(3):1601 – 1606.
  38. Öner Y, Yilmaz O, Okut H, Ata N, Mecitoğlu G, Keskin A: Associations Between GH, PRL, STAT5A, OPN, PIT-1, LEP and FGF2 Polymorphisms and Fertility in Holstein-Friesian Heifers. Kafkas Univ Vet Fak Derg 2017, 23(4):527-534.
  39. Thuy NTD, Thu NT, Cuong NH, Ty LV: Polymorphism of PIT-1 and Prolactin Genes and Their Effects on Milk Yield in Holstein Frisian Dairy Cows Bred in Vietnam. Russ J Genet 2018, 54:346-352.
  40. Bayram D, Arslan K, Akyüz B, İşcan KM: Identification of pituitary-specific transcription factor-1 (PIT-1) and leptin gene (LEP) polymorphism of Holstein cattle reared in Turkey. Ankara Üniv Vet Fak Derg 2017, 64(4):337-343.
  41. Gökcan G: Associations Between Pit-1/HinfI Gene Polymorphism and Some Fattening Performance Characteristics in Holstein Cattle. Ms Thesis, Selçuk University, Konya, 2019.
  42. Fındık I, Özdemir M: polymorphism of Pit-1 and CSN3 genes in Holstein calves and its associations with calf birth weight. Arch Anim Breed 2022, 65(3):285-292.
  43. Aytekin I, Boztepe S: Associations of Pit-1 gene polymorphism with milk yield and composition traits in Brown Swiss cattle. J Anim Plant Sci 2013, 23:1281-1289.
  44. Chauhan A, Tiwari M, Sharma D, Kumar S, Goel R, Bhattacharyya A, Singh V, Pal Singh S: Association of PIT-1 gene polymorphism with milk production traits in Sahiwal cattle. The Indian J Anim Sci 2015, 85:610-612.
  45. Selvaggi M, Dario C: Analysis of two Pit-1 gene polymorphisms: Single nucleotide polymorphisms (SNPs) distribution patterns in Podolica cattle breed. Afr J Biotechnol 2011, 10(55): 11360-11364.
  46. Grossi Ddo A, Buzanskas ME, Grupioni NV, de Paz CC, Regitano LC, de Alencar MM, Schenkel FS, Munari DP: Effect of IGF1, GH, and Pit-1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle. Mol Biol Rep 2015, 42(1):245-251.
  47. Gritsienko Y, Gill M, Karatieievа O: Connection between gene markers with milk production traits of Ukrainian dairy cows. Online J Anim Feed Res 2022, 12(5):302-313.
  48. Doosti A, Asghar A, Behnam M: Molecular study of PIT1 gene polymorphism in Holstein and Iranian native cattle. Afr. J. Agric. Res. 2011, 6(19):4467-4470.
  49. Zabeel A, Albazi W, Ali H: Study the association of pit1 gene polymorphism with milk yield and body weight traits of local breed Iraqı cattle in Kerbala province. Biochemistry Cell Biol 2018, 18:1867-1871.
DOI: https://doi.org/10.2478/acve-2025-0029 | Journal eISSN: 1820-7448 | Journal ISSN: 0567-8315
Language: English
Page range: 387 - 402
Submitted on: Dec 3, 2024
Accepted on: Jun 26, 2025
Published on: Sep 18, 2025
Published by: University of Belgrade, Faculty of Veterinary Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Related subjects:

© 2025 Elif Çelik Gürbulak, Esma Gamze Aksel, published by University of Belgrade, Faculty of Veterinary Medicine
This work is licensed under the Creative Commons Attribution 4.0 License.