Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product

Viktor Milata; Eva Holúbková

doi:10.2478/acs-2020-0014

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Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product

Acta Chimica Slovaca

Volume 13 (2020): Issue 1 (April 2020)

By: Viktor Milata and Eva Holúbková

Open Access

|Jun 2020

Abstract

Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.

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Articles in this issue

DOI: https://doi.org/10.2478/acs-2020-0014 | Journal eISSN: 1339-3065 | Journal ISSN: 1337-978X

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Language: English

Page range: 98 - 101

Published on: Jun 29, 2020

Published by: Slovak University of Technology in Bratislava

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Related subjects:

Chemistry,

Chemistry, other

© 2020 Viktor Milata, Eva Holúbková, published by Slovak University of Technology in Bratislava
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 13 (2020): Issue 1 (April 2020)