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Pan-Cdk inhibitor ZK304709 suppresses Cdc20 expression and potentiates the anticancer activity of apcin in HeLa cervical cancer cells Cover

Pan-Cdk inhibitor ZK304709 suppresses Cdc20 expression and potentiates the anticancer activity of apcin in HeLa cervical cancer cells

Acta Pharmaceutica
AHEAD OF PRINT
By: Xiangyang Le,  Qingsong Chen,  Shuyang Cao,  Gaoyun Hu,  Qianbin Li and  Zhuo Chen  
Open Access
|Dec 2025

Authors

Xiangyang Le

Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Hunan, China
Department of Pharmacy, Yiyang Central Hospital, Hunan, China

Qingsong Chen

Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Hunan, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Hunan, China
Hunan Key Laboratory of Organ Fibrosis, Hunan, China

Shuyang Cao

Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Hunan, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Hunan, China
Hunan Key Laboratory of Organ Fibrosis, Hunan, China

Gaoyun Hu

Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Hunan, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Hunan, China
Hunan Key Laboratory of Organ Fibrosis, Hunan, China

Qianbin Li

Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Hunan, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Hunan, China
Hunan Key Laboratory of Organ Fibrosis, Hunan, China

Zhuo Chen

cz_job@csu.edu.cn

Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Hunan, China
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Hunan, China
Hunan Key Laboratory of Organ Fibrosis, Hunan, China
DOI: https://doi.org/10.2478/acph-2026-0002 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
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Language: English
Accepted on: Oct 5, 2025
Published on: Dec 17, 2025
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
cell division cycle 20 homologue,
cyclin-dependent kinase 1,
combination chemotherapy,
synergistic effects,
anti-tumour activity
Related subjects:
Pharmacy,
Pharmacy, other

© 2025 Xiangyang Le, Qingsong Chen, Shuyang Cao, Gaoyun Hu, Qianbin Li, Zhuo Chen, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

AHEAD OF PRINT