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Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists Cover

Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists

Acta Pharmaceutica
Volume 75 (2025): Issue 2 (June 2025)
By: Nika Strašek Benedik,  Valerij Talagayev,  Troy Matziol,  Ana Dolšak,  Izidor Sosič,  Günther Weindl,  Gerhard Wolber and  Matej Sova  
Open Access
|Jul 2025

Authors

Nika Strašek Benedik

University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ljubljana, Slovenia

Valerij Talagayev

Freie Universität Berlin, Institute of Pharmacy, Pharmaceutical and Medicinal Chemistry, Berlin, Germany

Troy Matziol

University of Bonn, Pharmaceutical Institute, Pharmacology and Toxicology Section, Bonn, Germany

Ana Dolšak

University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ljubljana, Slovenia

Izidor Sosič

University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ljubljana, Slovenia

Günther Weindl

guenther.weindl@uni-bonn.de

University of Bonn, Pharmaceutical Institute, Pharmacology and Toxicology Section, Bonn, Germany

Gerhard Wolber

gerhard.wolber@fu-berlin.de

University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ljubljana, Slovenia

Matej Sova

matej.sova@ffa.uni-lj.si

University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ljubljana, Slovenia
DOI: https://doi.org/10.2478/acph-2025-0011 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
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Language: English
Page range: 159 - 183
Accepted on: Mar 28, 2025
|
Published on: Jul 3, 2025
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Toll-like receptors,
TLR8 antagonists,
autoimmune disorders,
immunomodulation,
pyrimidines
Related subjects:
Pharmacy,
Pharmacy, other

© 2025 Nika Strašek Benedik, Valerij Talagayev, Troy Matziol, Ana Dolšak, Izidor Sosič, Günther Weindl, Gerhard Wolber, Matej Sova, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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