Abstract
Headaches are one of the most common reasons why patients seek help in the emergency department, and alcohol consumption is a well-known cause. Wine, in particular, is associated with headaches not only due to its alcohol content but also due to the presence of polyphenols and biogenic amines such as tyramine, putrescine, and, notably, histamine. Wine consumption is on the rise around the world and is likely to be reflected in headache prevalence. Understanding the mechanisms underlying wine-induced headaches can help in their management and prevention Therefore, we provide a comprehensive review of the pathophysiology of wine induced headaches.