Genetic dysfunctions leading to the pathogenic cascade of atopic dermatitis

Verschuren, Jeya; Wozniak, Slawomir

doi:10.2478/acb-2023-0014

Abstract

Atopic dermatitis is a skin disorder caused by the dysfunction of a multitude of genetic components. This paper reviewed three main genetic factors leading to the pathogenesis of atopic dermatitis including: the epidermal barrier, the body’s immune system, and the filaggrin protein.

References

Frazier W, Bhardwaj N. Atopic dermatitis: diagnosis and treatment. Am Fam Physician. 2020;101(10):590-8.
Search in Google Scholar Back to article
Avena-Woods C. Overview of atopic dermatitis. Am J Manag Care. 2017;23(8 Suppl):S115-S23.
Search in Google Scholar Back to article
Bawany F, Northcott CA, Beck LA, Pigeon WR. Sleep disturbances and atopic dermatitis: relationships, methods for assessment, and therapies. J Allergy Clin Immunol Pract. 2021;9(4):1488-1500; DOI:10.1016/j. jaip.2020.12.007.
Search in Google Scholar Back to article
Kim J, Kim BE, Leung DYM. Pathophysiology of atopic dermatitis: clinical implications. Allergy Asthma Proc. 2019;40(2):84-92; DOI:10.2500/aap.2019.40.4202.
Search in Google Scholar Back to article
Mu Z, Zhang J. The Role of Genetics, the Environment, and Epigenetics in Atopic Dermatitis. Adv Exp Med Biol. 2020;1253:107-140; DOI:10.1007/978-981-15-3449-2_4.
Search in Google Scholar Back to article
Madison KC. Barrier function of the skin: “la raison d’e tre” of the epidermis. J Invest Dermatol. 2003 Aug;121(2):231-41; DOI:10.1046/j.1523-1747.2003.12359.x.
Search in Google Scholar Back to article
Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Guy RH, Macgowan AL, Tazi-Ahnini R, Ward SJ. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009 Aug;129(8):1892-908; DOI:10.1038/jid.2009.133.
Search in Google Scholar Back to article
Has C. Peeling Skin Disorders: A paradigm for skin desquamation. J Invest Dermatol. 2018 Aug;138(8):1689-1691; DOI:10.1016/j. jid.2018.05.020.
Search in Google Scholar Back to article
Lee SE, Jeong SK, Lee SH. Protease and protease-activated receptor-2 signaling in the pathogenesis of atopic dermatitis. Yonsei Med J. 2010;51(6):808-22; DOI:10.3349/ymj.2010.51.6.808.
Search in Google Scholar Back to article
Chipps B. When asthma is more than just asthma: type 2 inflammation [Internet]. Fairfax: Allergy & Asthma Network; 2023 [cited: 2023 Jul 23]. Available from: https://allergyasthmanetwork.org/news/when-asthma-more-than-asthma-type-inflammation/.
Search in Google Scholar Back to article
Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez JV, Peng G, Yue H, Nguyen LTH, Niyonsaba F. Keratinocytes: innate immune cells in atopic dermatitis. Clin Exp Immunol. 2021;204(3):296-309; DOI:10.1111/cei.13575.
Search in Google Scholar Back to article
Fania L, Moretta G, Antonelli F, Scala E, Abeni D, Albanesi C, Madonna S. Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets. Int J Mol Sci. 2022;23(5):2684; DOI:10.3390/ijms23052684.
Search in Google Scholar Back to article
Facheris P, Jeffery J, Del Duca E, Guttman-Yassky E. The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment. Cell Mol Immunol. 2023;20(5):448-74; DOI:10.1038/s41423-023-00992-4.
Search in Google Scholar Back to article
Fu J, Huang Y, Bao T, Liu C, Liu X, Chen X. The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A. J Neuroinflammation. 2022;19(1):98; DOI:10.1186/s12974-022-02446-6.
Search in Google Scholar Back to article
Furue M. Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis. Int J Mol Sci. 2020;21(15):5382; DOI:10.3390/ijms21155382.
Search in Google Scholar Back to article
Bieber T. Interleukin-13: Targeting an underestimated cytokine in atopic dermatitis. Allergy. 2020;75(1):54-62; DOI:10.1111/all.13954.
Search in Google Scholar Back to article
Chiricozzi A, Maurelli M, Peris K, Girolomoni G. Targeting IL-4 for the Treatment of Atopic Dermatitis. Immunotargets Ther. 2020;9:151-6; DOI:10.2147/ITT.S260370.
Search in Google Scholar Back to article
Campion M, Smith L, Gatault S, Me tais C, Buddenkotte J, Steinhoff M. Interleukin-4 and interleukin-13 evoke scratching behaviour in mice. Exp Dermatol. 2019;28(12):1501-4; DOI:10.1111/exd.14034.
Search in Google Scholar Back to article
Drislane C, Irvine AD. The role of filaggrin in atopic dermatitis and allergic disease. Ann Allergy Asthma Immunol. 2020;124(1):36-43; DOI:10.1016/j.anai.2019.10.008.
Search in Google Scholar Back to article
Kim Y, Lim KM. Skin barrier dysfunction and filaggrin. Arch Pharm Res. 2021;44(1):36-48; DOI:10.1007/s12272-021-01305-x.
Search in Google Scholar Back to article
Moosbrugger-Martinz V, Leprince C, Me chin MC, Simon M, Blunder S, Gruber R, Dubrac S. Revisiting the roles of filaggrin in atopic dermatitis. Int J Mol Sci. 2022;23(10):5318; DOI:10.3390/ijms23105318.
Search in Google Scholar Back to article
Armengot-Carbo M, Hernández-Martín Á, Torrelo A. The role of filaggrin in the skin barrier and disease development. Actas Dermosifiliogr. 2015;106(2):86-95. English, Spanish; DOI:10.1016/j.ad.2013.10.019.
Search in Google Scholar Back to article

Genetic dysfunctions leading to the pathogenic cascade of atopic dermatitis

Abstract

Paradigm

My account