References
- 1. Karastergiou K, Mohamed-Ali V. The autocrine and paracrine roles of adipokines. Mol Cell Endocrinol. 2010;318; DOI:10.1016/j.mce.2009.11.011.
- 2. Mancuso P. The role of adipokines in chronic inflammation. ImmunoTar-gets Ther. 2016;5; DOI:10.2147/ITT.S73223.
- 3. Frühbeck G, Catalán V, Rodrí guez A, Gómez-Ambrosi J. Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. Adipocyte. 2018;7; DOI:10.1080/21623945.2017.1402151.
- 4. Satoh N, Naruse M, Usui T, Tagami T, Suganami T, Yamada K, Kuzuya H, Shimatsu A, Ogawa Y. Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care. 2004;27; DOI:10.2337/diacare.27.10.2488.
- 5. Gutaj P, Sibiak R, Jankowski M, Awdi K, Bryl R, Mozdziak P, Kempisty B, Wender-Ozegowska E. The Role of the Adipokines in the Most Common Gestational Complications. Int J Mol Sci. 2020;21:9408; DOI:10.3390/ijms21249408.
- 6. Inuzuka H, Nishizawa H, Inagaki A, Suzuki M, Ota S, Miyamura H, Miyazaki J, Sekiya T, Kurahashi H, Udagawa Y. Decreased expression of apelin in placentas from severe pre-eclampsia patients. Hypertens Pregnancy. 2013;32; DOI:10.3109/10641955.2013.813535.
- 7. Couvineau P, Llorens-Cortes C, Iturrioz X. Elabela/Toddler and apelin bind differently to the apelin receptor. FASEB J. 2020;34:7989–8000; DOI:10.1096/fj.201903029R.
- 8. Ho L, Van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GHY, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science (80-). 2017;357; DOI:10.1126/science.aam6607.
- 9. Zhou Q, Zhang K, Guo Y, Chen L, Li L. Elabela-APJ axis contributes to embryonic development and prevents pre-eclampsia in pregnancy. Acta Biochim Biophys Sin (Shanghai). 2018;50:319–21; DOI:10.1093/abbs/gmx143.
- 10. Hassan SS, Gomez-Lopez N. Reducing maternal mortality: can elabela help in this fight? Lancet. 2019;394:8–9; DOI:10.1016/S0140-6736(19)30543-4.
- 11. Ma J, Hu H, Lin M, Chen L, Liu M, Li H, Quan S. ELABELA alleviates syncytiotrophoblast hypoxia/reoxygenation injury and preeclampsia-like symptoms in mice by reducing apoptosis. Placenta. 2021;106:30–9; DOI:10.1016/j.placenta.2021.02.002.33610935
- 12. Georgiadou D, Boussata S, Ranzijn WHM, Root LEA, Hillenius S, bij de Weg JM, Abheiden CNH, de Boer MA, de Vries JIP, Vrijkotte TGM, Lam-balk CB, Kuijper EAM, Afink GB, van Dijk M. Peptide hormone ELABELA enhances extravillous trophoblast differentiation, but placenta is not the major source of circulating ELABELA in pregnancy. Sci Rep. 2019;9; DOI:10.1038/s41598-019-55650-5.691103931836787
- 13. Zhou L, Sun H, Cheng R, Fan X, Lai S, Deng C. ELABELA, as a potential diagnostic biomarker of preeclampsia, regulates abnormally shallow placentation via APJ. Am J Physiol Metab. 2019;316:E773–81; DOI:10.1152/ajpendo.00383.2018.30860880
- 14. Wang L, Zhang Y, Qu H, Xu F, Hu H, Zhang Q, Ye Y. Reduced ELABELA expression attenuates trophoblast invasion through the PI3K/AKT/mTOR pathway in early onset preeclampsia. Placenta. 2019;87:38–45; DOI:10.1016/j.placenta.2019.08.077.31546152
- 15. Wang X, Liang G, Guo Q, Cai W, Zhang X, Ni J, Tao Y, Niu X, Chen S. ELABELA improves endothelial cell function via the ELA–APJ axis by activating the PI3K/Akt signalling pathway in HUVECs and EA.hy926 cells. Clin Exp Pharmacol Physiol. 2020:1440-1681.13382; DOI:10.1111/1440-1681.13382.32687618
- 16. Huang R, Zhu J, Zhang L, Hua X, Ye W, Chen C, Sun K, Wang W, Feng L, Zhang J. Is ELABELA a reliable biomarker for hypertensive disorders of pregnancy? Pregnancy Hypertens. 2019;17:226–32; DOI:10.1016/j.preghy.2019.06.007.700177131487645
- 17. Hao S, You J, Chen L, Zhao H, Huang Y, Zheng L, Tian L, Maric I, Liu X, Li T, Bianco YK, Winn VD, Aghaeepour N, Gaudilliere B, Angst MS, Zhou X, Li Y-M, Mo L, Wong RJ, Shaw GM, Stevenson DK, Cohen HJ, Mcelhinney DB, Sylvester KG, Ling XB. Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia. PLoS One. 2020;15:e0230000; DOI:10.1371/journal.pone.0230000.705375332126118
- 18. Ozgen G, Aydin GA, Ayvaci H. Predictive Role of First-trimester ELABELA Levels for Late-onset Preeclampsia. J Coll Physicians Surg Pakistan. 2021;31:916–20; DOI:10.29271/jcpsp.2021.08.916.34320707
- 19. Ma S, Guo C, Zhang J, Long S, Tan H, You Y, Chase PB. Association between ELABELA Serum Concentrations in First Trimester and Pregnancy-Induced Hypertension. Biomed Res Int. 2020;2020:1–5; DOI:10.1155/2020/2051701.753910133062670
- 20. Pritchard N, Kaitu’u-Lino TJ, Gong S, Dopierala J, Smith GCS, Charnock-Jones DS, Tong S. ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia. Am J Pathol. 2018;188; DOI:10.1016/j.ajpath.2018.04.008.606399629803833
- 21. Panaitescu B, Romero R, Gomez-Lopez N, Pacora P, Erez O, Vadillo-Ortega F, Yeo L, Hassan SS, Hsu C-D. ELABELA plasma concentrations are increased in women with late-onset preeclampsia. J Matern Neonatal Med. 2020;33:5–15; DOI:10.1080/14767058.2018.1484089.634267529890874
- 22. Villie P, Lefevre G, Arrestier R, Rousseau A, Berkane N, Hertig A. ELABELA concentration is not decreased in maternal plasma before the onset of preeclampsia. Am J Obstet Gynecol. 2019;220:284–5; DOI:10.1016/j.ajog.2018.12.020.30576665
- 23. Para R, Romero R, Gomez-Lopez N, Tarca AL, Panaitescu B, Done B, Hsu R, Pacora P, Hsu CD. Maternal circulating concentrations of soluble Fas and Elabela in early- and late-onset preeclampsia. J Matern Neonatal Med. 2020; DOI:10.1080/14767058.2020.1716720.32008387
- 24. Deniz R, Baykus Y, Ustebay S, Ugur K, Yavuzkir Ş, Aydin S. Evaluation of elabela, apelin and nitric oxide findings in maternal blood of normal pregnant women, pregnant women with pre-eclampsia, severe pre-eclampsia and umbilical arteries and venules of newborns. J Obstet Gynaecol (Lahore). 2019;39; DOI:10.1080/01443615.2019.1572727.31064239
- 25. International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy. Diabetes Care. 2010;33:676–82; DOI:10.2337/dc09-1848.282753020190296
- 26. Guo YY, Li T, Liu H, Tang L, Li YC, Hu HT, Su YF, Lin Y, Wang YY, Li C, Huang HF, Jin L, Liu XM. Circulating levels of Elabela and Apelin in the second and third trimesters of pregnancies with gestational diabetes mellitus. Gynecol Endocrinol. 2020; DOI:10.1080/09513590.2020.1739264.32208782
- 27. Karagoz ZK, Aydin S, Ugur K, Tigli A, Deniz R, Baykus Y, Sahin I, Yalcin MH, Yavuz A, Aksoy A, Aydin S. Molecular communication between Apelin-13, Apelin-36, Elabela, and nitric oxide in gestational diabetes mellitus. Eur Rev Med Pharmacol Sci. 2022;26:3289–300; DOI:10.26355/eurrev_202205_28748.35587081
- 28. Behram M, Oğlak SC, Dağ İ. Circulating levels of Elabela in pregnant women complicated with intrauterine growth restriction. J Gynecol Obstet Hum Reprod. 2021;50:102127; DOI:10.1016/j.jogoh.2021.102127.33781971
- 29. Yener G, Kavak SB, Gul Y, Celik Kavak E, Gulcu Bulmus F, Sanli C, Batmaz I, Bulu G. Elabela levels in pregnancies with intrauterine growth retardation. Ginekol Pol. 2022; DOI:10.5603/GP.a2021.0246.35315019