References
- 1. Ståhl A-L, Johansson K, Mossberg M, Kahn R, Karpman D. Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases. Pediatr Nephrol. 2019;34(1):11–30; DOI:10.1007/S00467-017-3816-Z/TABLES/3.
- 2. Shehzad A, Islam SU, Shahzad R, Khan S, Lee YS. Extracellular vesicles in cancer diagnostics and therapeutics. Pharmacol Ther. 2021;223:107806; DOI:10.1016/J.PHARMTHERA.2021.107806.10.1016/j.pharmthera.2021.10780633465400
- 3. Pegtel DM, Gould SJ. Exosomes. Ann Rev Bioch. 2019;88:487–514; DOI:10.1146/ANNUREV-BIOCHEM-013118-111902.10.1146/annurev-biochem-013118-11190231220978
- 4. Wang J, Chen D, Ho EA. Challenges in the development and establishment of exosome-based drug delivery systems. J Control Release. 2021;329:894–906; DOI:10.1016/J.JCONREL.2020.10.020.10.1016/j.jconrel.2020.10.02033058934
- 5. Lai RC, Chen TS, Lim SK. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen Med. 2011;6(4):481–92; DOI:10.2217/RME.11.35/ASSET/IMAGES/LARGE/FIGURE2.JPEG.
- 6. Chen J, Chopp M. Exosome therapy for stroke. Stroke. 2018;49(5):1083–90; DOI:10.1161/STROKEAHA.117.018292.10.1161/STROKEAHA.117.018292602893629669873
- 7. Moon B, Chang S. Exosome as a delivery vehicle for cancer therapy. Cells 2022;11(3):316; DOI:10.3390/CELLS11030316.10.3390/cells11030316883456035159126
- 8. Arraud N, Linares R, Tan S, Gounou C, Pasquet JM, Mornet S, Brisson AR. Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration. J Thromb Haemost. 2014;12(5):614–27; DOI:10.1111/JTH.12554.10.1111/jth.1255424618123
- 9. Raposo G, Nijman HW, Stoorvogel W, Leijendekker R, Harding C V., Melief CJM, Geuze HJ. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 1996;183(3):1161–72; DOI:10.1084/JEM.183.3.1161.10.1084/jem.183.3.116121923248642258
- 10. Smith ZJ, Lee C, Rojalin T, Carney RP, Hazari S, Knudson A, Lam K, Saari H, Ibañez EL, Viitala T, Laaksonen T, Yliperttula M, Wachsmann-Hogiu S. Single exosome study reveals subpopulations distributed among cell lines with variability related to membrane content. J Extracell Vesicles. 2015;4(1):28533; DOI:10.3402/JEV.V4.28533/SUPPL_FILE/ZJEV_A_11815546_SM0001.PDF.
- 11. Bobrie A, Colombo M, Raposo G, Théry C. Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses. Traffic. 2011;12(12):1659–68; DOI:10.1111/J.1600-0854.2011.01225.X.10.1111/j.1600-0854.2011.01225.x21645191
- 12. Li X, Corbett AL, Taatizadeh E, Tasnim N, Little JP, Garnis C, Daugaard M, Guns E, Hoorfar M, Li ITS. Challenges and opportunities in exosome research - perspectives from biology, engineering, and cancer therapy. APL Bioeng. 2019;3(1):011503; DOI:10.1063/1.5087122.10.1063/1.5087122648174231069333
- 13. Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science 2020;367(6478); DOI:10.1126/SCIENCE.AAU6977.10.1126/science.aau6977771762632029601
- 14. Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P. Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications. Int J Nanomedicine. 2020;15:6917; DOI:10.2147/IJN.S264498.10.2147/IJN.S264498751982733061359
- 15. Livshts MA, Khomyakova E, Evtushenko EG, Lazarev VN, Kulemin NA, Semina SE, Generozov E V., Govorun VM. Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol. Sci Rep. 2015;5; DOI:10.1038/SREP17319.10.1038/srep17319466348426616523
- 16. Cvjetkovic A, Lötvall J, Lässer C. The influence of rotor type and centrifugation time on the yield and purity of extracellular vesicles. J Extracell Vesicles. 2014;3(1); DOI:10.3402/JEV.V3.23111.10.3402/jev.v3.23111396701524678386
- 17. Ford T, Graham J, Rickwood D. Iodixanol: a nonionic iso-osmotic centrifugation medium for the formation of self-generated gradients. Anal Biochem. 1994;220(2):360–6; DOI:10.1006/ABIO.1994.1350.10.1006/abio.1994.13507978279
- 18. Van Deun J, Mestdagh P, Agostinis P, Akay O, Anand S, Anckaert J, Martinez ZA, Baetens T, Beghein E, Bertier L, Berx G, Boere J, Boukouris S, Bremer M, Buschmann D, Byrd JB, Casert C, Cheng L, Cmoch A, Daveloose D, De Smedt E, Demirsoy S, Depoorter V, Dhondt B, Driedonks TAP, Dudek A, Elsharawy A, Floris I, Foers AD, Gärtner K, Garg AD, Geeurickx E, Gettemans J, Ghazavi F, Giebel B, Kormelink TG, Hancock G, Helsmoortel H, Hill AF, Hyenne V, Kalra H, Kim D, Kowal J, Kraemer S, Leidinger P, Leonelli C, Liang Y, Lippens L, Liu S, Lo Cicero A, Martin S, Mathivanan S, Mathiyalagan P, Matusek T, Milani G, Monguió-Tortajada M, Mus LM, Muth DC, Németh A, Nolte-’T Hoen ENM, O’Driscoll L, Palmulli R, Pfaffl MW, Primdal-Bengtson B, Romano E, Rousseau Q, Sahoo S, Sampaio N, Samuel M, Scicluna B, Soen B, Steels A, Swinnen J V., Takatalo M, Thaminy S, Théry C, Tulkens J, Van Audenhove I, Van Der Grein S, Van Goethem A, Van Herwijnen MJ, Van Niel G, Van Roy N, Van Vliet AR, Vandamme N, Vanhauwaert S, Vergauwen G, Verweij F, Wallaert A, Wauben M, Witwer KW, Zonneveld MI, De Wever O, Vandesompele J, Hendrix A. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nat Methods. 2017;14(3):228–32; DOI:10.1038/NMETH.4185.10.1038/nmeth.418528245209
- 19. Vergauwen G, Dhondt B, Van Deun J, De Smedt E, Berx G, Timmerman E, Gevaert K, Miinalainen I, Cocquyt V, Braems G, Van Den Broecke R, Denys H, De Wever O, Hendrix A. Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research. Sci Rep. 2017;7(1); DOI:10.1038/S41598-017-02599-Y.10.1038/s41598-017-02599-y545743528577337
- 20. Yang F, Liao X, Tian Y, Li G. Exosome separation using microfluidic systems: size-based, immunoaffinity-based and dynamic methodologies. Biotechnol J. 2017;12(4):1600699; DOI:10.1002/BIOT.201600699.10.1002/biot.20160069928166394
- 21. Rider MA, Hurwitz SN, Meckes DG. ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles. Sci Rep. 2016;6; DOI:10.1038/SREP23978.10.1038/srep23978482863527068479
- 22. Li P, Kaslan M, Lee SH, Yao J, Gao Z. Progress in Exosome Isolation Techniques. Theranostics. 2017;7(3):789; DOI:10.7150/THNO.18133.10.7150/thno.18133532765028255367
- 23. Hirahata T, Quraish R, Quraish A, Quraish S, Naz M, Razzaq MA. Liquid biopsy: a distinctive approach to the diagnosis and prognosis of cancer: Cancer Inform. 2022;21: 11769351221076062; DOI:10.1177/11769351221076062.10.1177/11769351221076062883257435153470
- 24. Sun Z, Shi K, Yang S, Liu J, Zhou Q, Wang G, Song J, Li Z, Zhang Z, Yuan W. Effect of exosomal miRNA on cancer biology and clinical applications. Mol Cancer 2018 171. 2018;17(1):1–19; DOI:10.1186/S12943-018-0897-7.10.1186/s12943-018-0897-7618284030309355
- 25. Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW, Jing Q. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J. 2010;31(6):659–66; DOI:10.1093/EURHEARTJ/EHQ013.10.1093/eurheartj/ehq01320159880
- 26. Eichelser C, Stückrath I, Müller V, Milde-Langosch K, Wikman H, Pantel K, Schwarzenbach H. Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients. Oncotarget. 2014;5(20):9650–63; DOI:10.18632/ONCOTARGET.2520.10.18632/oncotarget.2520425942725333260
- 27. Rotelli MT, Di Lena M, Cavallini A, Lippolis C, Bonfrate L, Chetta N, Portincasa P, Altomare DF. Fecal microRNA profile in patients with colorectal carcinoma before and after curative surgery. Int J Color Dis. 2015;30(7):891–8; DOI:10.1007/S00384-015-2248-0.10.1007/s00384-015-2248-025989926
- 28. Matsumura T, Sugimachi K, Iinuma H, Takahashi Y, Kurashige J, Sawada G, Ueda M, Uchi R, Ueo H, Takano Y, Shinden Y, Eguchi H, Yamamoto H, Doki Y, Mori M, Ochiya T, Mimori K. Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer. Br J Cancer. 2015;113(2):275–81; DOI:10.1038/BJC.2015.201.10.1038/bjc.2015.201450638726057451
- 29. Huang X, Yuan T, Liang M, Du M, Xia S, Dittmar R, Wang D, See W, Costello BA, Quevedo F, Tan W, Nandy D, Bevan GH, Longenbach S, Sun Z, Lu Y, Wang T, Thibodeau SN, Boardman L, Kohli M, Wang L. Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. Eur Urol. 2015;67(1):33–41; DOI:10.1016/J.EURURO.2014.07.035.10.1016/j.eururo.2014.07.035425260625129854
- 30. Tatischeff I, Alfsen A. A New Biological Strategy for Drug Delivery: Eucaryotic Cell-Derived Nanovesicles. J Biomater Nanobiotechnol. 2011;02(05):494–9; DOI:10.4236/JBNB.2011.225060.10.4236/jbnb.2011.225060
- 31. Didiot MC, Hall LM, Coles AH, Haraszti RA, Godinho BMDC, Chase K, Sapp E, Ly S, Alterman JF, Hassler MR, Echeverria D, Raj L, Morrissey D V., Di Figlia M, Aronin N, Khvorova A. Exosome-mediated delivery of hydrophobically modified siRNA for Huntingtin mRNA silencing. Mol Ther. 2016;24(10):1836–47; DOI:10.1038/MT.2016.126.10.1038/mt.2016.126511203827506293
- 32. Lee J, Lee H, Goh U, Kim J, Jeong M, Lee J, Park JH. Cellular engineering with membrane fusogenic liposomes to produce functionalized extracellular vesicles. ACS Appl Mater Interfaces. 2016;8(11):6790–5; DOI:10.1021/ACSAMI.6B01315.10.1021/acsami.6b0131526954538
- 33. Fuhrmann G, Serio A, Mazo M, Nair R, Stevens MM. Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. J Control Release. 2015;205:35–44; DOI:10.1016/J.JCONREL.2014.11.029.10.1016/j.jconrel.2014.11.02925483424
- 34. Wei W, Ao Q, Wang X, Cao Y, Liu Y, Zheng SG, Tian X. Mesenchymal stem cell - derived exosomes: a promising biological tool in nanomedicine. Front Pharmacol. 2021;11:1954; DOI:10.3389/FPHAR.2020.590470/BIBTEX.
- 35. Rani S, Ritter T. The exosome - a naturally secreted nanoparticle and its application to wound healing. Adv Mater. 2016;28(27):5542–52; DOI:10.1002/ADMA.201504009.10.1002/adma.20150400926678528