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Susceptibility of spike glycoprotein and RNA-dependent RNA polymerase of SARS-CoV-2 to mutation: in silico structural dynamics study Cover

Susceptibility of spike glycoprotein and RNA-dependent RNA polymerase of SARS-CoV-2 to mutation: in silico structural dynamics study

Medical Journal of Cell Biology
Volume 9 (2021): Issue 4 (December 2021)
By: Toluwase Hezekiah Fatoki,  Jude Akinyelu,  Oluwafijimi Yomi Adetuyi,  Temitope Olawale Jeje,  Uchechukwu Nebo,  Jesupemi Mercy Fatoki and  Tolulope Mercy Kupolati  
Open Access
|Dec 2021

Figures & Tables

FIGURE 1

Structural dynamics of RNA-dependent RNA polymerase (PDB ID: 7BW4, chain A) and its mutant consisting of G228C, P323L, V330E, and D824Y. (A) Superimposition of 10 model structures of 7BW4 from CAB-flex 2.0 server. (B) Superimposition of 10 model structures of 7BW4 mutant from CAB-flex 2.0 server. (C) RMSF of amino acids residues in 7BW4 and 7BW4 mutant. (D) Comparison of model protein structures from Dali Server
Structural dynamics of RNA-dependent RNA polymerase (PDB ID: 7BW4, chain A) and its mutant consisting of G228C, P323L, V330E, and D824Y. (A) Superimposition of 10 model structures of 7BW4 from CAB-flex 2.0 server. (B) Superimposition of 10 model structures of 7BW4 mutant from CAB-flex 2.0 server. (C) RMSF of amino acids residues in 7BW4 and 7BW4 mutant. (D) Comparison of model protein structures from Dali Server

FIGURE 2

Structural dynamics of Spike glycoprotein (PDB ID: 7CAB, chain A). and its mutant consisting of T478K, E484K, N501Y, D614G, and A701V. (A) Superimposition of 10 model structures of 7CAB from CAB-flex 2.0 server. (B) Superimposition of 10 model structures of 7CAB mutant from CAB-flex 2.0 server. (C) RMSF of amino acids residues in 7CAB and 7CAB mutant. (D) Comparison of model protein structures from Dali Server
Structural dynamics of Spike glycoprotein (PDB ID: 7CAB, chain A). and its mutant consisting of T478K, E484K, N501Y, D614G, and A701V. (A) Superimposition of 10 model structures of 7CAB from CAB-flex 2.0 server. (B) Superimposition of 10 model structures of 7CAB mutant from CAB-flex 2.0 server. (C) RMSF of amino acids residues in 7CAB and 7CAB mutant. (D) Comparison of model protein structures from Dali Server
DOI: https://doi.org/10.2478/acb-2021-0020 | Journal eISSN: 2544-3577
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Language: English
Page range: 148 - 152
Submitted on: Oct 2, 2021
Accepted on: Nov 18, 2021
Published on: Dec 30, 2021
Published by: Foundation for Cell Biology and Molecular Biology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
SARS-CoV-2,
omicron variant,
spike glycoprotein,
RNA-dependent RNA polymerase,
mutation,
structural analysis
Related subjects:
Life sciences,
Molecular biology,
Biochemistry

© 2021 Toluwase Hezekiah Fatoki, Jude Akinyelu, Oluwafijimi Yomi Adetuyi, Temitope Olawale Jeje, Uchechukwu Nebo, Jesupemi Mercy Fatoki, Tolulope Mercy Kupolati, published by Foundation for Cell Biology and Molecular Biology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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