Table 1
Gene symbols, fold changes in expression, Entrez gene IDs and corrected p values of studied genes
| GENE SYMBOL | FOLD. CHANGE D15/D7 | FOLD. CHANGE D30/D7 | FOLD. CHANGE D30/D15 | ADJUSTED P.VALUE D15/D7 | ADJUSTED P.VALUE D30/D7 | ADJUSTED P.VALUE D30/D15 | GENEID |
|---|---|---|---|---|---|---|---|
| SERPINB2 | 0,041199 | 0,012677 | 0,008239 | 4,60E-06 | 7,45E-07 | 2,31E-07 | 1,01E+08 |
| CD274 | 0,04424 | 0,04443 | 0,041834 | 2,50E-06 | 7,45E-07 | 2,31E-07 | 574058 |
| TXNIP | 0,082179 | 0,64453 | 0,63523 | 1,11E-05 | 0,024019 | 0,017645 | 733688 |
| IL24 | 0,083371 | 0,062192 | 0,071399 | 9,50E-06 | 3,21E-06 | 1,76E-06 | 1,01E+08 |
| HSH2D | 0,123575 | 0,083464 | 0,094409 | 2,25E-05 | 5,06E-06 | 3,79E-06 | 1,01E+08 |
| IDO1 | 0,134544 | 0,12111 | 0,123331 | 7,22E-05 | 3,53E-05 | 2,36E-05 | 1,01E+08 |
| MX1 | 0,147313 | 0,355975 | 0,489162 | 1,87E-05 | 0,000197 | 0,00096 | 397128 |
| IFIT3 | 0,172101 | 0,195012 | 0,31317 | 1,87E-05 | 1,28E-05 | 4,60E-05 | 1E+08 |
| SNAI2 | 0,183766 | 0,134521 | 0,130079 | 0,000411 | 0,000129 | 7,85E-05 | 641345 |
| XAF1 | 0,196155 | 0,456355 | 0,66362 | 0,000162 | 0,004319 | 0,06338 | --- |
| PTTG1 | 5,573407 | 4,839927 | 0,818891 | 5,27E-05 | 4,98E-05 | 0,269018 | 397015 |
| CDKN2B | 5,906076 | 5,279248 | 5,031711 | 6,22E-06 | 3,39E-06 | 1,81E-06 | 397227 |
| KIF20A | 6,182894 | 6,001182 | 0,588195 | 0,000319 | 0,000249 | 0,063892 | 1,01E+08 |
| KIF23 | 6,49686 | 7,105965 | 7,104752 | 0,000647 | 0,000382 | 0,000271 | 1,01E+08 |
| TTK | 6,595833 | 6,064142 | 0,629174 | 0,000194 | 0,000163 | 0,078507 | --- |
| DLGAP5 | 7,403844 | 6,551599 | 0,699776 | 9,17E-05 | 8,22E-05 | 0,131054 | 1,01E+08 |
| GAS2L3 | 7,739168 | 7,035903 | 1,559417 | 8,27E-05 | 6,71E-05 | 0,064706 | 1E+08 |
| UBE2C | 8,523298 | 4,717957 | 0,372658 | 0,000914 | 0,00366 | 0,025648 | 1E+08 |
| HHEX | 9,447447 | 11,82395 | 11,30739 | 2,69E-05 | 9,59E-06 | 6,25E-06 | 397232 |
| CENPF | 9,506242 | 6,960497 | 0,773239 | 0,000484 | 0,000742 | 0,52224 | 1,01E+08 |
Figure 1
Heat map representation of differentially expressed genes belonging to the to “cell cycle” and “cell death” GO BP terms. Arbitrary signal intensity acquired from microarray analysis is represented by colors (green, higher; red, lower expression). Log2 signal intensity values for any single gene were resized to Row Z-Score scale (from -2, the lowest expression to +2, the highest expression for single gene)
Figure 2
The circle plot showing the differently expressed genes and z-score of “cell cycle” and “cell death” GO BP terms. The outer circle shows a scatter plot for each term of the fold change of the assigned genes. Red circles display upregulation and blue ones downregulation. The inner circle shows the z-score of each GO BP term. The width of the each bar corresponds to the number of genes within GO BP term and the color corresponds to the z-score
Figure 3
The representation of the mutual relationship 10 most upregulated and 10 most downregulated genes that belongs to the to “cell cycle” and “cell death” GO BP terms. The ribbons indicate which gene belongs to which categories. The middle circle represents logarithm from fold change (LogFC) between D7/D1, D15/D1 and D30/D1 respectively. The genes were sorted by logFC from most to least changed gene
Figure 4
Heatmap showing the gene occurrence between 10 most upregulated and 10 most downregulated genes that belongs “cell cycle” and “cell death” GO BP terms. The red color is associated with gene occurrence in the GO Term. The intensity of the color is corresponding to amount of GO BP terms that each gene belongs to
Figure 5
STRING-generated interaction occurrence between 10 most upregulated and 10 most dowregulated genes that belongs to “cell cycle” and “cell death” GO BP terms. The intensity of the edges reflects the strength of interaction score