The Role of Human Insulin Growth Factor (Igf) – Axis in Carcinogenesis

Wojciech Kwaśniewski; Józef Kotarski; Grzegorz Polak; Anna Goździcka-Józefiak; Jan Kotarski

doi:10.2478/acb-2014-0002

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The Role of Human Insulin Growth Factor (Igf) – Axis in Carcinogenesis

Medical Journal of Cell Biology

Volume 4 (2014): Issue 1 (March 2014)

By: Wojciech Kwaśniewski, Józef Kotarski, Grzegorz Polak, Anna Goździcka-Józefiak and Jan Kotarski

Open Access

|Oct 2014

Abstract

The human insulin-like growth factor (IGF) system has attracted significant researcher interest due to its endocrine and autocrine / paracrine activities, mitogenic effects and the involvement in the regulation of proliferation, differentiation and apoptosis. The signaling pathways used by the IGF system impact cellular metabolism in a complex manner complex and many details are still unclear. Understanding the molecular mechanism of action of IGF’s and their effects on cellular activity may provide a basis to develop new anticancer drugs. This review focuses on recent studies that expand our knowledge of the signaling pathways of IGF system

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Articles in this issue

DOI: https://doi.org/10.2478/acb-2014-0002 | Journal eISSN: 2544-3577

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Language: English

Page range: 25 - 42

Published on: Oct 15, 2014

Published by: Foundation for Cell Biology and Molecular Biology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

IGFI,

IGF-R,

IGFBP,

Related subjects:

© 2014 Wojciech Kwaśniewski, Józef Kotarski, Grzegorz Polak, Anna Goździcka-Józefiak, Jan Kotarski, published by Foundation for Cell Biology and Molecular Biology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 4 (2014): Issue 1 (March 2014)