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Neonatal sevoflurane anesthesia can also affect rat medulla spinalis Cover

Neonatal sevoflurane anesthesia can also affect rat medulla spinalis

Open Access
|Jun 2025

Figures & Tables

Table 1.

Results of 8th, 15th, and 30th days tail flick tests of control and sevoflurane groups

8th day15th day30th day
Control group9.40 (7–14.9)10.70 (7.7–14.9)9.30 (6.3–13.7)*
Sevoflurane group9.40 (4.2–14.9)11.35 (6.0–14.9)5.95 (3.8–10.2)*

Results are given as median (min–max).

* P < 0.05 when compared with 8th day results.

Figure 1.

Crystal violet-stained sections of the rat spinal cords. (A) acute control, (B) chronic control, (C) acute sevoflurane, and (D) chronic sevoflurane groups. Arrows showing pyknotic cells. Bars = 50 μm.

Table 2.

The percentage of TUNEL-positive cells of ACont, ASevo, CCont, and CSevo groups

GroupsnTUNEL (%) (Mean ± SEM)
ACont64.28 ± 0.68
ASevo69.85 ± 0.50
CCont65.00 ± 0.65
CSevo619.14 ± 2.81
P (ACont vs. CSevo)<0.001*
P (ASevo vs. CSevo)0.001*
P (CCont vs. CSevo)<0.001*

†* P < 0.05 compared with other groups.

ACont, acute control; ASevo, acute sevoflurane; CCont, chronic control; CSevo, chronic sevoflurane; SEM, standard error of the mean.

Figure 2.

TUNEL staining. Representative photomicrographs of TUNEL-positive cells (arrows). (A) acute control, (B) chronic control, (C) acute sevoflurane, and (D) chronic sevoflurane groups. Bars = 50 μm.

DOI: https://doi.org/10.2478/abm-2025-0017 | Journal eISSN: 1875-855X | Journal ISSN: 1905-7415
Language: English
Page range: 141 - 146
Published on: Jun 30, 2025
Published by: Chulalongkorn University
In partnership with: Paradigm Publishing Services

© 2025 Elvan Ocmen, Hale Aksu Erdost, Osman Yilmaz, Alper Bagriyanik, Muge Kiray, Necati Gokmen, published by Chulalongkorn University
This work is licensed under the Creative Commons Attribution 4.0 License.