Assessment of photobiomodulation in response to the microcirculation in arteriovenous fistula for hemodialysis patient

Chang, Yi-Ping; Su, Chuan-Tsung; Hsieh, Ya-Hui; Meng, Fan-Chieh; Wu, Jih-Huah

doi:10.2478/abm-2025-0005

Abstract

Background

Management of blood flow in arteriovenous fistula (AVF) is a critical clinical issue for hemodialysis (HD) patients.

Objectives

To determine the effect of microcirculation of AVF in HD patients with photobiomodulation (PBM).

Methods

Twenty HD patients were enrolled in this study. PBM was used to radiate the palm of HD patients at a total dose of 126 J, and the microcirculatory analysis in AVF was investigated.

Results

Among the patients <65 years old, there is an increase of 2.31% and 1.37% in the average velocity and flux in AVF, respectively. This increase is higher than those observed in patients aged >65 years old. Additionally, the cumulative effect of the 830 nm laser was observed for at least 10 min, resulting in continuous increases of 3.16% in velocity and 1.59% in flux for HD patients <65 years old. On the contrary, the average velocity and flux in AVF increased in patients who had undergone HD for <6 years.

Conclusions

In this study, the age and the duration of HD treatment are the two factors that influence microcirculation in HD patients with PBM. The results suggest that PBM could be used to improve the average velocity and flux in AVF, particularly for younger patients with shorter HD treatment durations.

References

Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS, et al. Global prevalence of chronic kidney disease – a systematic review and meta-analysis. PLoS One. 2016; 11:e0158765. doi: 10.1371/journal.pone.0158765
Open DOI Search in Google Scholar Back to article
Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. 2015; 385:1975–82.
Search in Google Scholar Back to article
United States Renal Data System. 2018 USRDS annual data report: epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD. 2018.
Search in Google Scholar Back to article
Nordyke RJ, Reichert H, Bylsma LC, Jackson JJ, Gage SM, Fryzek J, et al. Costs attributable to arteriovenous fistula and arteriovenous graft placements in hemodialysis patients with Medicare coverage. Am J Nephrol. 2019; 50:320–8.
Search in Google Scholar Back to article
Thamer M, Lee TC, Wasse H, Glickman MH, Qian J, Gottlieb D, et al. Medicare costs associated with arteriovenous fistulas among US hemodialysis patients. Am J Kidney Dis. 2018; 72:10–8.
Search in Google Scholar Back to article
Hudson R, Johnson D, Viecelli A. Pathogenesis and prevention of vascular access failure. Vasc Access Surg Tips Tricks. 2019; 6:13–6.
Search in Google Scholar Back to article
Hung TW, Wu SW, Chiou JY, Wang YH, Liao YC, Wei CC. Association of permanent vascular access dysfunction with subsequent risk of cardiovascular disease: a population-based cohort study. J Pers Med. 2022; 12:598. doi: 10.3390/jpm12040598
Open DOI Search in Google Scholar Back to article
Feldman HI, Kobrin S, Wasserstein A. Hemodialysis vascular access morbidity. J Am Soc Nephrol. 1996; 7:523–35.
Search in Google Scholar Back to article
Allon M. Vascular access for hemodialysis patients: new data should guide decision making. Clin J Am Soc Nephrol. 2019; 14:954–61.
Search in Google Scholar Back to article
Stolic R. Most important chronic complications of arteriovenous fistulas for hemodialysis. Med Princ Pract. 2013; 22:220–8.
Search in Google Scholar Back to article
Paun M, Beach K, Ahmad S, Hickman R, Meissner M, Plett C, et al. New ultrasound approaches to dialysis access monitoring. Am J Kidney Dis. 2000; 35:477–81.
Search in Google Scholar Back to article
Campos RP, Do Nascimento MM, Chula DC, Do Nascimento DE, Riella MC. Stenosis in hemodialysis arteriovenous fistula: evaluation and treatment. Hemodial Int. 2006; 10:152–61.
Search in Google Scholar Back to article
Casserly LF, Dember LM. Thrombosis in end-stage renal disease. Semin Dial. 2003; 16:245–56.
Search in Google Scholar Back to article
Al-Jaishi AA, Liu AR, Lok CE, Zhang JC, Moist LM. Complications of the arteriovenous fistula: a systematic review. J Am Soc Nephrol. 2017; 28:1839–50.
Search in Google Scholar Back to article
Windus DW. Permanent vascular access: a nephrologist's view. Am J Kidney Dis. 1993; 21:457–71.
Search in Google Scholar Back to article
Viecelli AK, Mori TA, Roy-Chaudhury P, Polkinghorne KR, Hawley CM, Johnson DW, et al. The pathogenesis of hemodialysis vascular access failure and systemic therapies for its prevention: optimism unfulfilled. Semin Dial. 2018; 31:244–57.
Search in Google Scholar Back to article
Chang TI, Chen CH, Hsieh HL, Chen CY, Hsu SC, Cheng HS, et al. Effects of cardiovascular medications on primary patency of hemodialysis arteriovenous fistula. Sci Rep. 2020; 10:1–8.
Search in Google Scholar Back to article
Kim DH, Han D, Kim J, Park HC, Lee YK, Shin DG, et al. Vasodilator agents improve hemodialysis vascular access patency: a population-based study from Korea. Medicine. 2021; 100:e27439. doi: 10.1097/MD.0000000000027439
Open DOI Search in Google Scholar Back to article
Patel J, Chang S, Manawar S, Munn J, Rummel MC, Johnston D, et al. Effectiveness and safety of repeated percutaneous intervention in an office-based endovascular center in maintaining hemodialysis access. Vascular. 2022; 30:229–37.
Search in Google Scholar Back to article
Karakayali F, Basaran O, Ekici Y, Budakoglu I, Aytekin C, Boyvat F, et al. Effect of secondary interventions on patency of vascular access sites for hemodialysis. Eur J Vasc Endovasc Surg. 2006; 32:701–9.
Search in Google Scholar Back to article
Lin CC, Chang CF, Lai MY, Chen TW, Lee PC, Yang WC. Far-infrared therapy: a novel treatment to improve access blood flow and unassisted patency of arteriovenous fistula in hemodialysis patients. Randomized Controlled Trial. J Am Soc Nephrol. 2007; 18:985–92.
Search in Google Scholar Back to article
Lin CC, Yang WC, Chen MC, Liu WS, Yang CY, Lee PC. Effect of far infrared therapy on arteriovenous fistula maturation: an open-label randomized controlled trial. Am J Kidney Dis. 2013; 62:304–11.
Search in Google Scholar Back to article
Lai CC, Fang HC, Mar GY, Liou JC, Tseng CJ, Liu CP. Post-angioplasty far infrared radiation therapy improves 1-year angioplasty-free hemodialysis access patency of recurrent obstructive lesions. Eur J Vasc Endovasc Surg. 2013; 46:726–32.
Search in Google Scholar Back to article
Bashar K, Healy D, Browne LD, Kheirelseid EA, Walsh MT, Clarke-Moloney M, et al. Role of far infrared therapy in dialysis arteriovenous fistula maturation and survival: systematic review and meta-analysis. PLoS One. 2014; 9:e104931. doi: 10.1371/journal.pone.0104931
Open DOI Search in Google Scholar Back to article
Lindhard K, Rix M, Heaf JG, Hansen HP, Pedersen BL, Jensen BL, et al. Effect of far infrared therapy on arteriovenous fistula maturation, survival and stenosis in hemodialysis patients, a randomized, controlled clinical trial: the FAITH on fistula trial. BMC Nephrol. 2021; 22:1–9.
Search in Google Scholar Back to article
Stein A, Benayahu D, Maltz L, Oron U. Low-level laser irradiation promotes proliferation and differentiation of human osteoblasts in vitro. Photomed Laser Surg. 2005; 23:161–6.
Search in Google Scholar Back to article
Gomes FV, Mayer L, Massotti FP, Baraldi CE, Ponzoni D, Webber JB, et al. Low-level laser therapy improves peri-implant bone formation: resonance frequency, electron microscopy, and stereology findings in a rabbit model. Int J Oral Maxillofac Surg. 2015; 44:245–51.
Search in Google Scholar Back to article
Prabhu V, Rao SBS, Rao NB, Aithal KB, Kumar P, Mahato KK. Development and evaluation of fiber optic probe-based helium-neon low-level laser therapy system for tissue regeneration – an in vivo experimental study. Photochem Photobiol. 2010; 86:1364–72.
Search in Google Scholar Back to article
Gur A, Sarac AJ, Cevik R, Altindag O, Sarac S. Efficacy of 904nm gallium arsenide low level laser therapy in the management of chronic myofascial pain in the neck: a double-blind and randomize-controlled trial. Lasers Surg Med. 2004; 35:229–35.
Search in Google Scholar Back to article
Yamany AA, Salim SE. Efficacy of low level laser therapy for treatment myofascial trigger points of shoulder pain. World Appl Sci J. 2011; 12:758–64.
Search in Google Scholar Back to article
Jovičić M, Konstantinović L, Lazović M, Jovičić V. Clinical and functional evaluation of patients with acute low back pain and radiculopathy treated with different energy doses of low level laser therapy. Vojnosanit Pregl. 2012; 69:656–62.
Search in Google Scholar Back to article
Antonić R, Brumini M, Vidović I, Urek MM, Glažar I, Pezelj-Ribarić S. The effects of low level laser therapy on the management of chronic idiopathic orofacial pain: trigeminal neuralgia, temporomandibular disorders and burning mouth syndrome. Med Flum. 2017; 53:61–7.
Search in Google Scholar Back to article
Maegawa Y, Itoh T, Hosokawa T, Yaegashi K, Nishi M. Effects of near-infrared low-level laser irradiation on microcirculation. Lasers Surg Med. 2000; 27:427–37.
Search in Google Scholar Back to article
Ihsan FRM. Low-level laser therapy accelerates collateral circulation and enhances microcirculation. Photomed Laser Surg. 2005; 23:289–94.
Search in Google Scholar Back to article
Logan ID, Mckenna PG, Barnett YA. An investigation of the cytotoxic and mutagenic potential of low-intensity laser irradiation in friend-erythroleukemia cells. Mutat Res. 1995; 347:67–71.
Search in Google Scholar Back to article
Walski T, Grzeszczuk-Kuć K, Berlik W, Synal-Kulczak I, Bohara R, Detyna J, et al. Effect of near-infrared blood photobiomodulation on red blood cell damage from the extracorporeal circuit during hemodialysis in vitro. Photonics. 2022; 9:341. doi: 10.3390/photonics9050341
Open DOI Search in Google Scholar Back to article
Schardong J, Falster M, Sisto IR, Barbosa APO, Normann TC, de Souza KS, et al. Photobiomodulation therapy increases functional capacity of patients with chronic kidney failure: randomized controlled trial. Lasers Med Sci. 2021; 36:119–29.
Search in Google Scholar Back to article
Bian J, Liebert A, Bicknell B, Chen XM, Huang C, Pollock CA. Therapeutic potential of photobiomodulation for chronic kidney disease. Int J Mol Sci. 2022; 23:8043. doi: 10.3390/ijms23148043
Open DOI Search in Google Scholar Back to article
Emam ZM, Abbas SA, El-Thakaby AH, Abd EL-Hameed MM, Farek AIM. Efficacy of low-level laser on renal pruritus in hemodialysis patients. Egypt J Hosp Med. 2020; 81:1571–5.
Search in Google Scholar Back to article
Pavesi VCS, Martins MD, Coracin FL, Sousa AS, Pereira BJ, Prates RA, et al. Effects of photobiomodulation in salivary glands of chronic kidney disease patients on hemodialysis. Lasers Med Sci. 2021; 36:1209–17.
Search in Google Scholar Back to article
Mohammadi MM, Raygani AAV, Ghobadi A, Samadzadeh S, Salari N. Effect of near-infrared light therapy based on acupoints on the severity of restless legs syndrome in patients undergoing hemodialysis: a single-blind, randomized controlled trial. Clin Med Res. 2018; 16:1–8.
Search in Google Scholar Back to article
Keszler A, Lindemer B, Broeckel G, Weihrauch D, Gao Y, Lohr NL. In vivo characterization of a red light-activated vasodilation: a photobiomodulation study. Front Physiol. 2022; 13:880158. doi: 10.3389/fphys.2022.880158
Open DOI Search in Google Scholar Back to article
Oishi JC, Moraes TF, Buzinari TC, Cárnio EC, Parizotto NA, Rodrigues GJ. Hypotensive acute effect of photobiomodulation therapy on hypertensive rats. Life Sci. 2017; 178:56–60.
Search in Google Scholar Back to article
Buzinari TC, Moraes TF, Cárnio EC, Lopes LA, Salgado HC, Rodrigues GJ. Photobiomodulation induces hypotensive effect in spontaneously hypertensive rats. Lasers Med Sci. 2020; 35:567–72.
Search in Google Scholar Back to article
Nawashiro H, Wada K, Nakai K, Sato S. Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state. Photomed Laser Surg. 2012; 30:231–3.
Search in Google Scholar Back to article
Rungta RL, Osmanski BF, Boido D, Tanter M, Charpak S. Light controls cerebral blood flow in naive animals. Nat Commun. 2017; 8:14191. doi: 10.1038/ncomms14191
Open DOI Search in Google Scholar Back to article
Frangez I, Cankar K, Ban Frangez H, Smrke DM. The effect of LED on blood microcirculation during chronic wound healing in diabetic and non-diabetic patients – a prospective, double-blind randomized study. Lasers Med Sci. 2017; 32:887–94.
Search in Google Scholar Back to article
Su CT, Shan YC, Fang W, Lin CW, Juan JH, Lu KT, Wu JH. A novel image analysis of light emitting diode array biostimulation applied on microcirculation. In: 2018 1st International Cognitive Cities Conference (IC3) IEEE, 2018 August 7–9, Okinawa, Japan. 2018; 280–3.
Search in Google Scholar Back to article
Gavish L, Hoffer O, Rabin N, Halak M, Shkilevich S, Shayovitz Y, et al. Microcirculatory response to photobiomodulation – why some respond and others do not: a randomized controlled study. Lasers Surg Med. 2020; 52:863–72.
Search in Google Scholar Back to article
Rossi M, Cupisti A, Morelli E, Tintori G, Fabbri A, Battini S, et al. Laser Doppler flowmeter assessment of skin microcirculation in uremic patients on hemodialysis treatment. Nephron. 1996; 73:544–8.
Search in Google Scholar Back to article
Okano K, Tsuruta Y, Yamashita T, Echida Y, Kabaya T, Nitta K. Cardiovascular autonomic neuropathy studied by a laser-Doppler blood flowmeter in hemodialysis patients. Intern Med. 2010; 49:2669–75.
Search in Google Scholar Back to article
Teichmann H-O, Herrmann TR, Bach T. Technical aspects of lasers in urology. World J Urol. 2007; 25:221–5.
Search in Google Scholar Back to article
Su CT, Chen CM, Chen CC, Wu JH. Dose analysis of photobiomodulation therapy in stomatology. Evid Based Complement Alternat Med. 2020; 2020:8145616. doi: 10.1155/2020/8145616
Open DOI Search in Google Scholar Back to article
Jacob M, Chappell D, Becker BF. Regulation of blood flow and volume exchange across the microcirculation. Crit Care. 2016; 20:1–3.
Search in Google Scholar Back to article
Tsukada K, Minamitani H, Sekizuka E, Oshio C. Image correlation method for measuring blood flow velocity in microcirculation: correlation ‘window’ simulation and in vivo image analysis. Physiol Meas. 2000; 21:459–71.
Search in Google Scholar Back to article
Japee SA, Pittman RN, Ellis CG. Automated method for tracking individual red blood cells within capillaries to compute velocity and oxygen saturation. Microcirculation. 2005; 12:507–15.
Search in Google Scholar Back to article
Kamoun WS, Schmugge SJ, Kraftchick JP, Clemens MG, Shin MC. Liver microcirculation analysis by red Blood cell motion modeling in intravital microscopy images. IEEE Trans Biomed Eng. 2007; 55:162–70.
Search in Google Scholar Back to article
Bouthier JD, Levenson JA, Simon AC, Bariety JM, Bourquelot PE, Safar ME. A noninvasive determination of fistula blood flow in dialysis patients. Artif Organs. 1983; 7:404–9.
Search in Google Scholar Back to article
Rittgers SE, Garcia-Valdez C, McCormick JT, Posner MP. Noninvasive blood flow measurement in expanded polytetrafluoroethylene grafts for hemodialysis access. J Vasc Surg. 1986; 3:635–42.
Search in Google Scholar Back to article
van Gemert MJC, Bruyninckx CMA. Simulated hemodynamic comparison of arteriovenous fistulas. J Vasc Surg. 1987; 6:39–44.
Search in Google Scholar Back to article
Ponikvar R, Buturović-Ponikvar J. Temporary hemodialysis catheters as a long-term vascular access in chronic hemodialysis patients. Ther Apher Dial. 2005; 9:250–3.
Search in Google Scholar Back to article
Karu TI, Afanasyeva NI, Kolyakov SF, Pyatibrat LV, Welser L. Changes in absorbance of monolayer of living cells induced by laser radiation at 633, 670, and 820 nm. IEEE J Sel Top Quant Electron. 2001; 7:982–8.
Search in Google Scholar Back to article
Jin K. A microcirculatory theory of aging. Aging Dis. 2019; 10:676–83.
Search in Google Scholar Back to article