Figure 1
Figure 2
Figure 3
Donor patient characteristics and wet weights of cartilage harvested
| Patient characteristic | No. of patients | % of total patients | Mean yield of wet cartilage ± SD (mg) | |
|---|---|---|---|---|
| Age (y) | 50–59 | 1 | 6 | 3430 |
| 60–69 | 6 | 33 | 3760 ± 1489 | |
| 70–79 | 8 | 44 | 4211 ± 1716 | |
| 80–89 | 3 | 17 | 2740 ± 1221 | |
| Sex | Male | 6 | 33 | 3708 ± 1035 |
| Female | 12 | 67 | 3804 ± 1781 | |
| Diagnosis | Femoral neck fracture | 11 | 61 | 3245 ± 1137 |
| Femoral head necrosis | 4 | 22 | 3253 ± 765 | |
| Hip osteoarthritis | 1 | 6 | 6450 | |
| Knee osteoarthritis | 2 | 11 | 6370 | |
Donor patient characteristics and chondrocyte yield for each treatment group
| Treatment | Characteristic | No. of patients | Chondrocyte yield (mean cells ±SD) | |
|---|---|---|---|---|
| Group I (n = 11): pronase E + collagenase IA | Age (y) | 60–69 | 4 | 2940 ± 629 |
| 70–79 | 6 | 2390 ± 1050 | ||
| 80–89 | 1 | 2130 | ||
| Sex | Male | 3 | 2514 ± 601 | |
| Female | 8 | 2586 ± 992 | ||
| Diagnosis | Femoral neck fracture | 6 | 2587 ± 1056 | |
| Femoral head necrosis | 2 | 3002 | ||
| Hip osteoarthritis | 1 | 3030 | ||
| Knee osteoarthritis | 2 | 1837 | ||
| Group II (n = 5): collagenase II | Age (y) | 50–59 | 1 | 2729 |
| 60–69 | 1 | 747 | ||
| 70–79 | 1 | 669 | ||
| 80–89 | 2 | 789 | ||
| Sex | Male | 2 | 1702 | |
| Female | 3 | 773 ± 119 | ||
| Diagnosis | Femoral neck fracture | 3 | 749 ± 133 | |
| Femoral head necrosis | 2 | 1738 | ||
| Group III (n = 2): pronase E + collagenase II | Age (y) | 60–69 | 1 | 1291 |
| 70–79 | 1 | 170 | ||
| Sex | Male | 1 | 1291 | |
| Female | 1 | 170 | ||
| Diagnosis | Femoral neck fracture | 2 | 730 | |
Donor patient characteristics and wet weight of harvested cartilage for each treatment group
| Group No. (cartilage treatment; sample size) | Patient No. | Age (y) | Sex | Diagnosis | Wet weight of cartilage (mg) (mean ± SD) |
|---|---|---|---|---|---|
| I (Pronase E + Collagenase IA; n = 11) | 1 | 76 | F | Left femoral neck fracture | 4396 ± 1546 |
| 2 | 62 | M | Right femoral head necrosis | ||
| 3 | 62 | F | Right femoral head necrosis | ||
| 4 | 81 | F | Right femoral neck fracture | ||
| 5 | 77 | M | Left femoral neck fracture | ||
| 6 | 62 | F | Left femoral neck fracture | ||
| 7 | 61 | F | Right knee osteoarthritis | ||
| 8 | 74 | M | Left femoral neck fracture | ||
| 9 | 75 | F | Left knee osteoarthritis | ||
| 10 | 70 | F | Right hip osteoarthritis | ||
| 11 | 79 | F | Left femoral neck fracture | ||
| II (Collagenase II; n = 5) | 12 | 83 | F | Left femoral neck fracture | 2854 ± 876.5 |
| 13 | 67 | F | Right femoral head necrosis | ||
| 14 | 55 | M | Right femoral head necrosis | ||
| 15 | 72 | F | Right femoral neck fracture | ||
| 16 | 87 | M | Left femoral neck fracture | ||
| III (Pronase E + Collagenase II; n = 2) | 17 | 64 | M | Left femoral neck fracture | 2640 |
| 18 | 72 | F | Left femoral neck fracture | ||