Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Ćurčić, Marijana; Janković, Saša; Jaćević, Vesna; Stanković, Sanja; Vučinić, Slavica; Durgo, Ksenija; Bulat, Zorica; Antonijević, Biljana

doi:10.2478/10004-1254-63-2012-2179

Abstract

The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg-1, 7.5 mg kg-1, or 15 mg kg-1 b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg-1, 2000 mg kg-1, or 4000 mg kg-1 b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.

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Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

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