Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Marijana Ćurčić; Saša Janković; Vesna Jaćević; Sanja Stanković; Slavica Vučinić; Ksenija Durgo; Zorica Bulat; Biljana Antonijević

doi:10.2478/10004-1254-63-2012-2179

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Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Archives of Industrial Hygiene and Toxicology

Volume 63 (2012): Issue 3 (September 2012)

By: Marijana Ćurčić, Saša Janković, Vesna Jaćević, Sanja Stanković, Slavica Vučinić, Ksenija Durgo, Zorica Bulat and Biljana Antonijević

Open Access

|Sep 2012

Abstract

The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg-1, 7.5 mg kg-1, or 15 mg kg-1 b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg-1, 2000 mg kg-1, or 4000 mg kg-1 b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.

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Articles in this issue

DOI: https://doi.org/10.2478/10004-1254-63-2012-2179 | Journal eISSN: 1848-6312 | Journal ISSN: 0004-1254

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Language: English, Croatian, Slovenian

Page range: 255 - 262

Published on: Sep 25, 2012

Published by: Institute for Medical Research and Occupational Health

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

BDE209,

Cd,

thyroid-stimulating hormone,

thyroxin,

triiodothyronin

Related subjects:

Medicine,

Basic medical science,

Basic medical science, other

© 2012 Marijana Ćurčić, Saša Janković, Vesna Jaćević, Sanja Stanković, Slavica Vučinić, Ksenija Durgo, Zorica Bulat, Biljana Antonijević, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons License.

Volume 63 (2012): Issue 3 (September 2012)