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Underidentification of Autism Spectrum Disorder in Females: A Case Series Illustrating the Unique Presentation of this Disorder in Young Women Cover

Underidentification of Autism Spectrum Disorder in Females: A Case Series Illustrating the Unique Presentation of this Disorder in Young Women

Open Access
|Nov 2013

References

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed.). VA: Arlington; 2013.
  2. United States Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders—Autism and developmental disabilities monitoring network, 14 sites, United States, 2008. Surveillance Summaries, MMWR 2012; 61(SS03):1–19.
  3. Fombonne E. Epidemiological surveys of autism and other pervasive developmental disorders: An update. J Autism Dev Disord 2003;33(4):365–82. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12959416.
  4. Fombonne E. The changing epidemiology of autism. J Appl Res Intellect Disab 2005;18(4):281–94. doi:10.1111/j.1468-3148.2005.00266.x.
  5. Baird G, Simonoff E, Pickles A, Chandler S, Loucas T., et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The Special Needs and Autism Project (SNAP). Lancet 2006;368(9531):210–5. doi:10.1016/S0140-6736(06)69041-7.
  6. Scott FJ, Baron-Cohen S, Bolton P, Brayne C. Brief report: Prevalence of autism spectrum conditions in children aged 5–11 years in Cambridgeshire, UK. Autism 2002;6(3):231–7. doi:10.1177/1362361302006003002.
  7. Thompson T, Caruso M, Ellerbeck K. Sex matters in autism and other developmental disabilities. J Intellect Disab 2003;7(4):345–62. doi:10.1177/1469004703074003.
  8. Ben-Itzchak E, Ben-Shachar S, Zachor DA. Specific neurological phenotypes in autism spectrum disorders are associated with sex presentation. Autism Res 2013;6(6):596-604. doi 10.1002/aur.1319.
  9. Verma D, Chakraborti B, Karmakar A, Bandyopadhyay T, Singh AS, Chatterjee A, et al. Sexual dimorphic effect in the genetic association of monoamine oxidase A (MAOA) markers with autism spectrum disorder. Prog Neuropsychopharmacol Biol Psychiatry 2014;50:11-20. doi: 10.1016/j.pnpbp.2013.11.010.
  10. Mouridsen SE, Rich B, Isager T. The sex ratio of full and half siblings of people diagnosed with an autism spectrum disorder: a Danish nationwide register study. Child Psychiatry Hum Dev 2013. doi: 10.1007/s10578-013-0419-1.
  11. Zwaigenbaum L, Bryson SE, Szatmari P, Brian J, Smith IM, Roberts W, et al. Sex differences in children with autism spectrum disorder identified within a high-risk infant cohort. J Autism Dev Disord 2012;42(12):2585-96. doi: 10.1007/s10803-012-1515-y.
  12. Van Wijngaarden-Cremers PJ, van Eaten E, Groen WB, Van Deurzen PA, Oosterling IJ, Van der Gaag RJ. Gender and age differences in the core triad of impairments in autism spectrum disorders: a systematic review and meta-analysis. J Autism Dev Disor. 2013. doi:10.1007/s10803-013-1913-9.
  13. Goldman S. Opinion: Sex, gender and the diagnosis of autism—a biosocial view of the male preponderance. Res Autism Spec Disord 2013;7(6):675-9. doi:10.1016/j.rasd.2013.02.006.
  14. Dworzynski K, Ronald A, Bolton P, Happe F. How different are girls and boys above and below the diagnostic threshold for autism spectrum disorders? J Am Acad of Child Psychiatry 2012; 51(8):788–97. doi:10.1016/j.jaac.2012.05.018.
  15. Kreiser NL, White SW. ASD in females: are we overstating the gender difference in diagnosis? Clin Child Fam Psychol Rev 2013;17:67-84. doi:10.1007/s10567-013-0148-9.
  16. Werling DM, Geschwind, DH. Sex differences in autism spectrum disorders. Curr Opin Neurol 2013;26:146-53.
  17. Begeer S, Mandell D, Wijnker-Holmes B, Venderbosch S, Rem D, Stekelenburg F, et al. Sex differences in the timing of identification among children and adults with autism spectrum disorders. J Autism Dev Disord. 2013;43(5):1151-6. doi:10.1007/s10803-012-1656-z.
  18. Giarelli E, Wiggins LD, Rice CE, Levy SE, Kirby RS, Pinto-Martin J, et al. Sex differences in the evaluation and diagnosis of autism spectrum disorders among children. Disab Health 2010;3(2):107–16. doi:10.1016/j.dhjo.2009.07.001.
  19. Baron-Cohen S. The extreme male brain theory of autism. Trends Cogn Sci 2002;6(6):248-54.
  20. Skuse DH. Imprinting, the X-chromosome, and the male brain: explaining sex differences in the liability to autism. Pediatr Res 2000;47(1):9–16.
  21. Robinson EB, Lichtenstein P, Anckarsäter H, Happé F, Ronald A. Examining and interpreting the female protective effect against autistic behavior. PNAS 2013; 110(13): 5258-62.
  22. Bussey K, Bandura A. Social cognitive theory of gender development and differentiation. Psychol Rev 1999;106(4):676–713. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10560326.
  23. Flannagan D, Perese S. Emotional references in mother daughter and mother-son dyads’ conversations about school. Sex Roles 1998;39(5):353–67. doi:10.1023/A:1018866908472.
  24. Larson R, Richards MH. Introduction: the changing life space of early adolescence. J Youth Adol 1989;18(6):501–9. doi:10.1007/BF02139070.
  25. Maccoby EE. The two sexes: growing up apart, coming together. Cambridge: Harvard University Press; 1998.
  26. Raffaelli M, Duckett E. ‘‘We were just talking…’’: conversations in early adolescence. J Youth Adol 1989;18(6):567–82. doi:10.1007/BF02139074.
  27. Attwood T. Asperger’s and girls. London: Jessica Kingsley Publications; 2006.
  28. Mazefsky CA, Herrington J, Siegel M, Scarpa A, Maddox BB, Scahill L, et al. The role of emotion regulation in autism spectrum disorders. Am Acad Child Psychiatry 2013;52(7):679-88.
  29. Mazefsky CA, White SW. Emotion regulation: concepts and practice in autism spectrum disorder. Psychiatr Clin North Am 2014;23(1):15-24. doi:10.1016/j.chc.2013.07.002
  30. Brown T, Dinardo P, Barlow DH. Anxiety Disorders Interview Schedule Adult Version (ADIS-IV): Client Interview Schedules. New York, NJ: Oxford University Press; 1994.
  31. Lord C, Rutter M, DiLavore PC, Risi S, Gotham K, Bishop SL. ADOS-2: Autism Diagnostic Observation Schedule. Los Angeles, CA: Western Psychological Services; 2012.
  32. Shattuck P, Durkin M, Maenner M, Newschaffer C, Mandell DS, Wiggins L, et al. The timing of identification among children with autism spectrum disorder: findings from a population-based surveillance study. J Am Acad Child Adolesc Psychiatry 2009; 48(5):474-83.
  33. Hartley SL, Sikora DM. Sex differences in autism spectrum disorder: an examination of developmental functioning, autistic symptoms, and coexisting behavior problems in toddlers. J Autism Dev Disord 2009;39(12):1715–22. doi:10.1007/s10803-009-0810.
  34. Mandy W, Cilvers R, Chowdhurry U, Salter G, Seigal A, Skuse D. Sex differences in autism spectrum disorder: evidence from a large sample of children and adolescents. J Autism Dev Disord 2012;42(7):1304-13. doi: 10.1007/s10803-011-1356-0.
  35. Mayes SD, Calhoun SL. Impact of IQ, age, SES, gender, and race on autistic symptoms. Res Autism Sp Disord 2011;5(2):749–57. doi:10.1016/j.rasd.2010.09.002.
  36. Holtmann M, Bolte S, Poustka F. Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology. Dev Med Child Neurol 2007;49(5):361–6. doi:10.1111/j.1469-8749.2007.00361.x.
  37. McLennan J, Lord C, Schopler E. Sex differences in higher functioning people with autism. J Autism Dev Disord 1993;23(2):217–27. doi:10.1007/BF01046216.
  38. Lai MC, Lombardo MV, Pasco G, Ruigrok ANV, Wheelwright SJ, et al. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS ONE 2011; 6(6):e20835. doi:10.1371/journal.pone.0020835.
  39. Nicholas JS, Charles JM, Carpenter LA, King LB, Jenner W, Spratt EG. Prevalence and characteristics of children with autism-spectrum disorders. Ann Epidemiol 2008;18(2):130-6.
  40. Hartung CM, Widiger TA. Gender differences in the diagnosis of mental disorders: conclusions and controversies of the DSM-IV. Psychol Bull 1998;123(3):260-78.
  41. May T, Cornish K, Rinehart N. Does gender matter? A one year follow-up of autistic, attention and anxiety symptoms in high-functioning children with autism spectrum disorder. J Autism Dev Disord 2013. doi:10.1007/s10803-013-1964-y.
  42. Solomon M, Miller M, Taylor SL, Hinshaw SP, Carter CS. Autism symptoms and internalizing psychopathology in girls and boys with autism spectrum disorders. J Autism Dev Disord 2012;42(1):48–59. doi:10.1007/s10803-011-1215-z.
  43. Rydén G, Rydén E, Hetta J. Borderline personality disorder and autism spectrum disorder in females: a cross-sectional study. Clin Neuropsychol 2008;5(1):22-30.
  44. Fitzgerald M. Borderline personality disorder and Asperger syndrome. Autism 2005;9(4):452.
  45. Pelletier G. Borderline personality disorder vs. Asperger’s disorder. J Am Acad Child Psychiatry 1998;37(11):1128.
  46. Kopp S, Gillberg C. Girls with social deficits and learning problems: autism, atypical Asperger syndrome or a variant of these conditions. Eur Child Adolesc Psychiatry 1992;1(2):89-99.
  47. Thompson RA. Emotion regulation: A theme in search of a definition. Monogr Soc Res Child Dev 1994;59(2-3):25-52. doi: 0.1111/j.1540-5834.1994.tb01276.x
  48. Pisula E, Kawa R, Szostakiewicz Ł, Łucka I, Kawa M, Rynkiewicz A. Autistic traits in male and female students and individuals with high functioning autism spectrum disorders measured by the Polish version of the Autism-Spectrum Quotient. PLoS One 2013;8(9). doi: 10.1371/journal.pone.0075236.
  49. Mazefsky CA, White SW. Adults with autism. In Volkmar FR, Paul R, Rogers SJ, Pelphrey KA (eds). Handbook of Autism Spectrum Disorders, 4th Ed. Hoboken, NJ: Wiley and Sons. Forthcoming 2014 February.
  50. Merikangas KR, He J, Burstein M, Swanson SA, Avenevoli S, Cui L, et al. Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A). J Am Acad Child Adolesc Psychiatry 2010;49(10):980-9.
  51. Johnson CP. Early clinical characteristics of children with autism. In: Gupta VB (ed). Autistic spectrum disorders in children. New York: Marcel Dekker, Inc., 2004; p.85-123.
  52. Ollendick TH, White SW. The presentation and classification of anxiety in autism spectrum disorder: where to from here? Clin Psychol Sci Prac 2012;19(4):352-5.
  53. Reiss S, Levitan GW, Szysko J. Emotional disturbance and mental retardation: diagnostic overshadowing. Am Mental Deficien 1982;86(6):567-74.
Language: English
Page range: 66 - 76
Published on: Nov 30, 2013
Published by: Psychiatric Research Unit
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2013 Andrea Trubanova, Katharine Donlon, Nicole L. Kreiser, Thomas H. Ollendick, Susan W. White, published by Psychiatric Research Unit
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.