Clinical synergistic antiepileptic drug (AED) combinations
| References | Synergistic combinations of AEDs |
|---|---|
| Rowan et al., 1983 | VPA with ESM |
| Leach, Brodie, 1994 | VGB with TGB |
| Brodie, Yuen, 1997 | VPA with LTG |
| Stephen et al., 1998 | LTG with TPM |
| Pisani et al., 1999 | VPA with LTG |
| Brodie, Munford, 1999 | CBZ with VGB or VPA |
| Perucca, 2006 | STP with CLB |
| Moeller et al., 2009 | VPA with LTG |
| Chung et al., 2010 | LCM with LEV |
| Flores et al., 2012 | LCM with AED sodium channel blockers |
| Brodie et al., 2014 | RTG with AED sodium channel blockers or AEDs with other MOAs |
Preclinical synergistic antiepileptic drug (AED) combinations
| References | Synergistic combinations of AEDs |
|---|---|
| Masuda et al., 1981 | PB with PHT |
| Chez et al., 1994 | VPA with PHT |
| Shank et al., 1994 | TPM with CBZ and PB |
| Borowicz et al., 2002 | GBP with CBZ, VPA, PHT and PB |
| Luszczki et al., 2003 | LTG with TPM |
| Cuadrado et al., 2002 | VPA with LTG |
| Luszczki et al., 2005* | TPM with FBM and OXC |
| Shandra et al., 2013 | LCM with CBZ, LTG, TPM, GBP and LEV |
| Russmann et al., 2016 | PER with ZNS |