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Investigating anti-D in an individual with the weak D type 2 genotype Cover

Investigating anti-D in an individual with the weak D type 2 genotype

Paid access
|Sep 2022

References

  1. Pham BN, Roussel M, Peyrard T, et al. Anti-D investigations in individuals expressing weak D type 1 or weak D type 2: allo- or autoantibodies? Transfusion 2011;51:2679–85. doi:10.1111/j.1537-2995.2011.03207.x
  2. Garratty G. Immune hemolytic anemia associated with negative routine serology. Semin Hematol 2005;42:156–64. doi:10.1053/j.seminhematol.2005.04.005
  3. Merry AH, Thomson EE, Rawlinson VI, Stratton F. Quantitation of IgG on erythrocytes: correlation of number of IgG molecules per cell with the strength of the direct and indirect antiglobulin tests. Vox Sang 1984;47:73–81. doi:10.1111/j.1423-0410.1984.tb01564.x
  4. Jäger U, Barcellini W, Broome CM, et al. Diagnosis and treatment of autoimmune hemolytic anemia in adults: recommendations from the First International Consensus Meeting. Blood Rev 2020;41:100648. doi:10.1016/j.blre.2019. 100648
  5. Wagner FF, Frohmajer A, Ladewig B, et al. Weak D alleles express distinct phenotypes. Blood 2000;95:2699–708.
  6. Flegel WA, Denomme GA, Queenan JT, et al. It’s time to phase out “serologic weak D phenotype” and resolve D types with RHD genotyping including weak D type 4. Transfusion 2020;60:855–9. doi:10.1111/trf.15741
  7. Sandler SG, Flegel WA, Westhoff CM, et al. It’s time to phase in RHD genotyping for patients with a serologic weak D phenotype. College of American Pathologists Transfusion Medicine Resource Committee Work Group. Transfusion 2015;55:680–9. doi:10.1111/trf.12941
  8. Wagner FF, Flegel WA. The Human RhesusBase, version 2.5. Available from http://rhesusbase.info. Updated on 18 March 2020. Accessed 13 January 2022.
  9. Kwon DH, Sandler SG, Flegel WA. DEL phenotype. Immunohematology 2017;33:125–32.
  10. Wagner FF, Gassner C, Müller TH, Schönitzer D, Schunter F, Flegel WA. Molecular basis of weak D phenotypes. Blood 1999;93:385–93.
  11. Flegel WA. Molecular genetics of RH and its clinical application. Transfus Clin Biol 2006;13:4–12. doi:10.1016/j. tracli.2006.02.011
  12. Flegel WA, Khull SR, Wagner FF. Primary anti-D immunization by weak D type 2 RBCs. Transfusion 2000;40:428–34. doi:10.1046/j.1537-2995.2000.40040428.x
  13. Borge PD Jr, Mansfield PM. The positive direct antiglobulin test and immune-mediated hemolysis. In: Cohn C, Delaney M, Johnson ST, Kaiz LM, Eds. Technical manual. 20th ed. Arlington, VA: AABB, 2020:429–55.
  14. Yazer MH, Triulzi DJ. The role of the elution in antibody investigations. Transfusion 2009;49:2395–9. doi:10.1111/j.1537-2995.2009.02304.x
  15. Melland C, Nance S. Other blood group systems and antigens. In: Cohn C, Delaney M, Johnson ST, Kaiz LM, Eds. Technical manual. 20th ed. Arlington, VA: AABB, 2020:375–7.
  16. Miola MP, Cervo SV, Fachini RM, Ricci Júnior O. Do not confuse anti-LW autoantibodies with anti-D. Rev Bras Hematol Hemoter 2013;35:198. doi:10.5581/1516-8484. 20130042
  17. Flegel WA. How I manage donors and patients with a weak D phenotype. Curr Opin Hematol 2006;13:476–83. doi:10.1097/01.moh.0000245694.70135.c3
  18. Wheeler CA, Calhoun L, Blackall DP. Warm reactive autoantibodies: clinical and serologic correlations. Am J Clin Pathol 2004;122:680–5. doi:10.1309/CJAW-6N8J-6H0H-R2WM
DOI: https://doi.org/10.21307/immunohematology-2022-046 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X
Language: English
Page range: 77 - 81
Published on: Sep 22, 2022
Published by: American National Red Cross
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2022 S. Phou, N. Nguyen, J. Revilla, K. Rodberg, D.R. Gibb, S.H. Pepkowitz, E.B. Klapper, published by American National Red Cross
This work is licensed under the Creative Commons License.